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Francis J. Castellino

Francis J. Castellino

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
25036
World Ranking
3492
National Ranking
1754

Overview

Francis J. Castellino is affiliated with the University of Notre Dame in the United States. Their research predominantly lies in the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on subfields such as Public Health, Environmental and Occupational Health, Molecular Biology, Infectious Diseases, Clinical Biochemistry, and Epidemiology.

The scientist has contributed extensively to research on various medical topics, particularly in Streptococcal infections and treatments. Other main topics of work include Neonatal and Maternal Infections, Bacterial Identification and Susceptibility Testing, Antimicrobial Resistance in Staphylococcus, Biochemical and Structural Characterization, Protease and Inhibitor Mechanisms, and Urinary Tract Infections Management.

Frequent coauthors of Francis J. Castellino include:

  • Victoria A. Ploplis (24 co-publications)
  • Yetunde A. Ayinuola (16 co-publications)
  • Shaun W. Lee (14 co-publications)
  • Deborah L. Donahue (11 co-publications)
  • Zhong Liang (10 co-publications)

They have published multiple papers across notable scientific journals and venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory) with 7 publications
  • Journal of Biological Chemistry with 4 publications
  • Journal of Bacteriology with 2 publications
  • Frontiers in Cardiovascular Medicine with 2 publications
  • Current Drug Targets with 2 publications

Recent papers by Francis J. Castellino include:

  • Fibrin is a critical regulator of neutrophil effector function at the oral mucosal barrier (2021, Science)
  • The Streptococcal Protease SpeB Antagonizes the Biofilms of the Human Pathogen Staphylococcus aureus USA300 through Cleavage of the Staphylococcal SdrC Protein (2020, Journal of Bacteriology)
  • In situ metabolite and lipid analysis of GluN2D−/− and wild-type mice after ischemic stroke using MALDI MSI (2020, Analytical and Bioanalytical Chemistry)
  • Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy (2020, ACS Pharmacology & Translational Science)
  • Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension (2023, Circulation Research)

Best Publications

  • Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective.

    Tong Cheng;Dong Liu;John H. Griffin;José A. Fernández

  • Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo

    Sanchita Bhatnagar;Kazuhiko Shinagawa;Francis J. Castellino;Jeffrey S. Schorey

  • Structure and function of the plasminogen/plasmin system.

    Francis J. Castellino;Victoria A. Ploplis

  • Measurement of the binding of antifibrinolytic amino acids to various plasminogens

    William J. Brockway;Francis J. Castellino

  • Glycosylation of Pichia pastoris-derived proteins.

    Roger K. Bretthauer;Francis J. Castellino

  • The Complete Amino Acid Sequence of Bovine α-Lactalbumin

    Keith Brew;Francis J. Castellino;Thomas C. Vanaman;Robert L. Hill

  • The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin

    S Gately;P Twardowski;M S Stack;D L Cundiff

  • Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.

    Max V. Wohlauer;Ernest E. Moore;Ernest E. Moore;Scott Thomas;Scott Thomas;Angela Sauaia

  • Endotoxemia and sepsis mortality reduction by non-anticoagulant–activated protein C

    Edward J. Kerschen;José A. Fernandez;Brian C. Cooley;Xia V. Yang

  • Tumor Development Is Retarded in Mice Lacking the Gene for Urokinase-Type Plasminogen Activator or Its Inhibitor, Plasminogen Activator Inhibitor-1

    Linda S. Gutierrez;Alexis Schulman;Teresa Brito-Robinson;Francisco Noria

  • [29] Human plasminogen

    Francis J. Castellino;James R. Powell

  • Mice lacking factor VII develop normally but suffer fatal perinatal bleeding

    Elliot D. Rosen;Joyce C. Y. Chan;Esohe Idusogie;Frédéric Clotman

  • The fibrin-derived peptide Bβ 15-42 protects the myocardium against ischemia-reperfusion injury

    Peter Petzelbauer;Paula A Zacharowski;Yasuhiro Miyazaki;Peter Friedl

  • Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice.

    Louise R. Jalbert;Elliot D. Rosen;Lieve Moons;Joyce C.Y. Chan;Joyce C.Y. Chan

  • Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice.

    Mieke Dewerchin;Zhong Liang;Lieve Moons;Peter Carmeliet

  • FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse.

    Elliot D. Rosen;Dave Gailani;Francis J. Castellino

  • Oligosaccharide processing in the expression of human plasminogen cDNA by lepidopteran insect (Spodoptera frugiperda) cells

    Donald J. Davidson;Malcolm J. Fraser;Francis J. Castellino

  • Characterization of kringle domains of angiostatin as antagonists of endothelial cell migration, an important process in angiogenesis

    Weidong-Richard Ji;Francis J. Castellino;Yuan Chang;Melanie E. Deford

  • The effect of alpha-,omega-amino acids on human plasminogen structure and activation.

    B N Violand;R Byrne;F J Castellino

  • Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

    Zhihui Zhong;Hristelina Ilieva;Lee Hallagan;Robert Bell

Frequent Co-Authors

Lindsey A. Miles
Lindsey A. Miles Scripps Research Institute
John H. Griffin
John H. Griffin Scripps Research Institute
Desire Collen
Desire Collen KU Leuven
John G. Duman
John G. Duman University of Notre Dame
Ernest E. Moore
Ernest E. Moore University of Colorado Denver
José A. Fernández
José A. Fernández Scripps Research Institute
Dudley K. Strickland
Dudley K. Strickland American Red Cross
Lieve Moons
Lieve Moons KU Leuven
Berislav V. Zlokovic
Berislav V. Zlokovic University of Southern California

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