What is he best known for?
The fields of study he is best known for:
Francis J. Castellino mainly investigates Biochemistry, Immunology, Plasmin, Internal medicine and Stereochemistry.
His work on Recombinant DNA, Peptide sequence and Substrate as part of general Biochemistry research is frequently linked to Streptokinase, thereby connecting diverse disciplines of science.
His Immunology research is multidisciplinary, incorporating elements of Protein C and Receptor.
His Plasmin research includes elements of Cell, Cell migration, Zymogen, Fibrinolysis and Plasminogen activator.
The study incorporates disciplines such as Anesthesia, Endocrinology and Pathology in addition to Internal medicine.
His research integrates issues of Amino acid, Crystal structure, Binding site and Peptide in his study of Stereochemistry.
His most cited work include:
- Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. (512 citations)
- Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo (400 citations)
- Structure and function of the plasminogen/plasmin system. (331 citations)
What are the main themes of his work throughout his whole career to date?
Biochemistry, Molecular biology, Stereochemistry, Plasmin and Peptide are his primary areas of study.
The concepts of his Molecular biology study are interwoven with issues in Complementary DNA and Gene.
His studies in Stereochemistry integrate themes in fields like Amino acid, Protein structure, Divalent and Binding site.
Francis J. Castellino has researched Plasmin in several fields, including Plasminogen activator, Fibrinolysis, Activator and Urokinase.
The various areas that Francis J. Castellino examines in his Plasminogen activator study include Tissue plasminogen activator, Kringle domain and Cell biology.
His research investigates the connection between Protein C and topics such as Inflammation that intersect with issues in Endocrinology and Protein C deficiency.
He most often published in these fields:
- Biochemistry (30.74%)
- Molecular biology (20.70%)
- Stereochemistry (18.85%)
What were the highlights of his more recent work (between 2011-2021)?
- Streptococcus pyogenes (6.76%)
- Virulence (4.30%)
- Microbiology (4.92%)
In recent papers he was focusing on the following fields of study:
His primary areas of study are Streptococcus pyogenes, Virulence, Microbiology, Plasmin and Biochemistry.
His studies deal with areas such as Mutation, Molecular biology, Mutant and Staphylococcus aureus as well as Virulence.
In his research on the topic of Molecular biology, Urokinase, Binding domain and Fibrinolysis is strongly related with Plasminogen activator.
He interconnects Serine protease, Protease, Proteases, Protein–protein interaction and Extracellular matrix in the investigation of issues within Plasmin.
His work in Peptide, Peptide sequence, Conantokins and Proteolysis are all subfields of Biochemistry research.
His Cell biology study also includes
- Inflammation which connect with Pharmacology, Plasminogen activator inhibitor-1 and Fibrin,
- Receptor which is related to area like Stereochemistry.
Between 2011 and 2021, his most popular works were:
- Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. (213 citations)
- Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. (213 citations)
- Platelet Dysfunction is an Early Marker for Traumatic Brain Injury-Induced Coagulopathy (99 citations)
In his most recent research, the most cited papers focused on:
His primary areas of investigation include Coagulopathy, Platelet, Anesthesia, Streptococcus pyogenes and Microbiology.
Francis J. Castellino combines subjects such as Thrombosis and Thromboelastography with his study of Coagulopathy.
His work in Platelet covers topics such as Coagulation which are related to areas like Thrombin, Immunology, Antibody and Venous thrombosis.
As part of the same scientific family, he usually focuses on Anesthesia, concentrating on Thrombus and intersecting with Major trauma, Platelet transfusion, Prospective cohort study and Interquartile range.
As part of one scientific family, he deals mainly with the area of Streptococcus pyogenes, narrowing it down to issues related to the Virulence, and often Molecular biology and Complement C4b-Binding Protein.
His Plasmin study combines topics from a wide range of disciplines, such as Fibrinolysis, Plasminogen activator inhibitor-1 and Endocrinology.
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