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Biology and Biochemistry

D-Index
141
Citations
86517
World Ranking
255
National Ranking
172

Medicine

D-Index
141
Citations
86479
World Ranking
1608
National Ranking
937

Research.com Recognitions

  • 2016 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2012 - Fellow of the American Academy of Arts and Sciences
  • 2007 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

David T. Scadden is a researcher affiliated with Harvard University in the United States. Their work spans several areas within biomedical science, with a focus on medicine and biochemistry, genetics, and molecular biology. They have contributed extensively to the fields of molecular biology, hematology, immunology, oncology, and cancer research.

The research topics prominently associated with David T. Scadden include:

  • Hematopoietic Stem Cell Transplantation
  • Acute Myeloid Leukemia Research
  • Immune cells in cancer
  • Single-cell and spatial transcriptomics
  • Epigenetics and DNA Methylation
  • Cancer, Hypoxia, and Metabolism
  • Cancer Genomics and Diagnostics

Significant recent publications by David T. Scadden showcase varied investigations in both basic and translational biomedical research. Key papers include:

  • C9orf72 suppresses systemic and neural inflammation induced by gut bacteria, 2020, Nature
  • Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment, 2021, Cancer Cell
  • Lipid availability determines fate of skeletal progenitor cells via SOX9, 2020, Nature
  • Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses, 2023, Nature Communications
  • Health Consequences of Thymus Removal in Adults, 2023, New England Journal of Medicine

David T. Scadden maintains frequent collaborations with several co-authors, including:

  • David B. Sykes
  • Peter V. Kharchenko
  • Shenglin Mei
  • Azeem Sharda
  • Youmna Kfoury

The researcher has published many articles in notable scientific venues such as Blood, bioRxiv (Cold Spring Harbor Laboratory), Experimental Hematology, Blood Advances, and Cancer Research. Their publication record highlights a continued presence in leading journals related to hematology and cancer research.

Recognition of David T. Scadden's contributions is reflected in several honors. These include being named a Fellow of the American Association for the Advancement of Science in 2016, a Fellow of the American Academy of Arts and Sciences in 2012, membership in the National Academy of Medicine since 2007, and membership in the Association of American Physicians.

Best Publications

  • Osteoblastic cells regulate the haematopoietic stem cell niche

    Laura M Calvi;Gregor B Adams;K. W. Weibrecht;Jonathan Weber

  • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

    Simón Méndez-Ferrer;Tatyana V. Michurina;Francesca Ferraro;Amin R. Mazloom

  • Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

    Christopher G Willett;Yves Boucher;Emmanuelle di Tomaso;Dan G Duda

  • The bone marrow niche for haematopoietic stem cells

    Sean J. Morrison;David T. Scadden

  • The stem-cell niche as an entity of action

    David T. Scadden

  • Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells.

    Maïté Lewin;Nadia Carlesso;Ching Hsuan Tung;Xiao Wu Tang

  • AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients

    Tracy T. Batchelor;A. Gregory Sorensen;A. Gregory Sorensen;Emmanuelle di Tomaso;Wei Ting Zhang;Wei Ting Zhang

  • Hematopoietic stem cell quiescence maintained by p21cip1/waf1.

    Tao Cheng;Neil Rodrigues;Hongmei Shen;Yong-guang Yang

  • Bayesian approach to single-cell differential expression analysis

    Peter Vasili Kharchenko;Lev Silberstein;David Thomas Scadden

  • Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.

    Viktor Janzen;Randolf Forkert;Heather E. Fleming;Yoriko Saito

  • Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

    Marc H. G. P. Raaijmakers;Siddhartha Mukherjee;Shangqin Guo;Siyi Zhang

  • Direct measurement of local oxygen concentration in the bone marrow of live animals

    Joel A. Spencer;Francesca Ferraro;Emmanuel Roussakis;Alyssa Klein

  • In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

    Dorothy A. Sipkins;Xunbin Wei;Juwell W. Wu;Judith M. Runnels

  • Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

    Cristina Lo Celso;Heather E. Fleming;Juwell W. Wu;Cher X. Zhao

  • Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

    Keith W. Orford;David T. Scadden

  • Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

    Gregor B. Adams;Karissa T. Chabner;Ian R. Alley;Douglas P. Olson

  • A putative murine ecotropic retrovirus receptor gene encodes a multiple membrane-spanning protein and confers susceptibility to virus infection.

    Lorraine M. Albritton;Lena Tseng;David Scadden;James M. Cunningham

  • Differentiating the pathologies of cerebral malaria by postmortem parasite counts.

    Terrie E Taylor;Wenjiang J Fu;Wenjiang J Fu;Richard A Carr;Richard O Whitten

  • Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood

    Joshua Johnson;Jessamyn Bagley;Malgorzata Skaznik-Wikiel;Ho-Joon Lee

  • Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

    Mélanie Demers;Daniela S. Krause;Daphne Schatzberg;Kimberly Martinod;Kimberly Martinod

Frequent Co-Authors

Charles P. Lin
Charles P. Lin Harvard University
Jerome E. Groopman
Jerome E. Groopman Beth Israel Deaconess Medical Center
David Dombkowski
David Dombkowski Harvard University
Benjamin L. Ebert
Benjamin L. Ebert Harvard University
Peter V. Kharchenko
Peter V. Kharchenko Harvard University
Noopur Raje
Noopur Raje Harvard University
Henry M. Kronenberg
Henry M. Kronenberg Harvard University
Teru Hideshima
Teru Hideshima Harvard University
Rakesh K. Jain
Rakesh K. Jain Harvard University
Stuart L. Schreiber
Stuart L. Schreiber Harvard University

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