World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
128
Citations
75531
World Ranking
440
National Ranking
282

Medicine

D-Index
128
Citations
75587
World Ranking
2670
National Ranking
1491

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Shahin Rafii is affiliated with Cornell University in the United States and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their scholarly output encompasses molecular biology, immunology, surgery, hematology, and cell biology, reflecting a broad interdisciplinary research focus.

They have published 86 articles in Biochemistry, Genetics and Molecular Biology and 85 in Medicine, with significant subfield contributions including 61 papers in Molecular Biology, 21 in Immunology, 17 in Surgery, 17 in Hematology, and 14 in Cell Biology.

Rafii's research topics cover a range of specialized areas, including:

  • Single-cell and spatial transcriptomics
  • Zebrafish biomedical research applications
  • Renal and related cancers
  • Pancreatic function and diabetes
  • Hematopoietic stem cell transplantation
  • Immune cells in cancer
  • Epigenetics and DNA methylation

They have collaborated frequently with several researchers, including David Redmond (22 coauthored works), Ryan Schreiner (16), Jesús M. Gómez-Salinero (15), Cole Trapnell (15), and Brandon Hadland (15).

Rafii has published in numerous scientific venues, with notable recurring contributions to bioRxiv (Cold Spring Harbor Laboratory) with 10 publications, Blood with 7, Nature Communications with 4, Nature Cardiovascular Research with 4, and Transplantation with 4.

Among recent published works are:

  • "Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis," 2020, Nature
  • "Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate," 2021, Proceedings of the National Academy of Sciences
  • "Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo," 2021, Cell Reports
  • "Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid," 2020, The Journal of Experimental Medicine
  • "Reversal of emphysema by restoration of pulmonary endothelial cells," 2021, The Journal of Experimental Medicine

In 2012, Shahin Rafii was named a Fellow of the American Association for the Advancement of Science (AAAS), recognizing their standing within the scientific community.

Best Publications

  • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

    Rosandra N. Kaplan;Rebecca D. Riba;Stergios Zacharoulis;Anna H. Bramley

  • Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

    Mario Peichev;Afzal J. Naiyer;Daniel Pereira;Zhenping Zhu

  • Evidence for Circulating Bone Marrow-Derived Endothelial Cells

    Qun Shi;Shahin Rafii;Moses Hong-De Wu;Errol S. Wijelath

  • Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

    David Lyden;Koichi Hattori;Koichi Hattori;Sergio Dias;Carla Costa

  • Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

    Beate Heissig;Koichi Hattori;Sergio Dias;Matthias Friedrich

  • Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration.

    Shahin Rafii;David Lyden

  • Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

    Monica Garcia-Barros;Francois Paris;Carlos Cordon-Cardo;David Lyden

  • Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

    Aaron D. Goldberg;Laura A. Banaszynski;Kyung Min Noh;Peter W. Lewis

  • CD133 expression is not restricted to stem cells, and both CD133 + and CD133 – metastatic colon cancer cells initiate tumors

    Sergey V. Shmelkov;Jason M. Butler;Andrea T. Hooper;Adilia Hormigo

  • Vascular Trauma Induces Rapid but Transient Mobilization of VEGFR2+AC133+ Endothelial Precursor Cells

    Muhammad Gill;Sergio Dias;Koichi Hattori;Mary Lee Rivera

  • The Chemokine Receptor CXCR-4 Is Expressed on CD34+Hematopoietic Progenitors and Leukemic Cells and Mediates Transendothelial Migration Induced by Stromal Cell-Derived Factor-1

    Robert Möhle;Frank Bautz;Frank Bautz;Frank Bautz;Shahin Rafii;Shahin Rafii;Shahin Rafii;Malcolm A.S. Moore;Malcolm A.S. Moore;Malcolm A.S. Moore

  • Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

    Koichi Hattori;Sergio Dias;Beate Heissig;Neil R. Hackett

  • Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.

    Scott T. Avecilla;Koichi Hattori;Beate Heissig;Rafael Tejada

  • Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

    Shahin Rafii;David Lyden;David Lyden;Robert Benezra;Robert Benezra;Koichi Hattori

  • Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets

    Robert Möhle;David Green;Malcolm A. S. Moore;Ralph L. Nachman

  • Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

    Bi Sen Ding;Daniel J. Nolan;Jason M. Butler;Daylon James

  • Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1 + stem cells from bone-marrow microenvironment

    Koichi Hattori;Beate Heissig;Yan Wu;Sergio Dias

  • Angiocrine functions of organ-specific endothelial cells

    Shahin Rafii;Jason M. Butler;Bi-Sen Ding

  • Preparing the "soil": the premetastatic niche

    Rosandra N. Kaplan;Shahin Rafii;David Lyden

  • The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis.

    Isabelle Petit;David Jin;Shahin Rafii

Frequent Co-Authors

David Lyden
David Lyden Cornell University
Ronald G. Crystal
Ronald G. Crystal Cornell University
Malcolm A.S. Moore
Malcolm A.S. Moore Memorial Sloan Kettering Cancer Center
Neil R. Hackett
Neil R. Hackett Cornell University
Olivier Elemento
Olivier Elemento Cornell University
Zev Rosenwaks
Zev Rosenwaks Cornell University
Daniel J. Hicklin
Daniel J. Hicklin Eli Lilly (United States)
Irwin D. Bernstein
Irwin D. Bernstein Fred Hutchinson Cancer Research Center
Barbara L. Hempstead
Barbara L. Hempstead Cornell University
Fan Zhang
Fan Zhang University of British Columbia

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