World's Best Scientists 2026 revealed!
Ronald G. Crystal

Ronald G. Crystal

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Best Scientists
2025
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Biology and Biochemistry
USA
2026

D-Index & Metrics

Best Scientists

D-Index
191
Citations
123029
World Ranking
408
National Ranking
273

Biology and Biochemistry

D-Index
193
Citations
124808
World Ranking
46
National Ranking
39

Medicine

D-Index
193
Citations
125979
World Ranking
235
National Ranking
158

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Ronald G. Crystal is affiliated with Cornell University in the United States. Their research spans multiple areas within medicine, biochemistry, genetics, and molecular biology, with a focus on pulmonary and respiratory medicine, genetics, molecular biology, physiology, and epidemiology.

The main research topics covered in their work include:

  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Virus-based gene therapy research
  • Neonatal Respiratory Health Research
  • CRISPR and Genetic Engineering
  • Lysosomal Storage Disorders Research
  • Asthma and respiratory diseases
  • Vitamin D Research Studies

Recent publications authored or co-authored by Ronald G. Crystal include:

  • Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium, 2020, American Journal of Respiratory and Critical Care Medicine
  • Evaluating the state of the science for adeno-associated virus integration: An integrated perspective, 2022, Molecular Therapy
  • Metabolic and Metabo-Clinical Signatures of Type 2 Diabetes, Obesity, Retinopathy, and Dyslipidemia, 2021, Diabetes
  • Lung Microbiota and Metabolites Collectively Associate with Clinical Outcomes in Milder Stage Chronic Obstructive Pulmonary Disease, 2022, American Journal of Respiratory and Critical Care Medicine
  • Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture, 2020, Scientific Reports

Frequent co-authors working with Ronald G. Crystal include:

  • Robert J. Kaner
  • Alejandro P. Comellas
  • MeiLan K. Han
  • Christopher B. Cooper
  • Russell P. Bowler

The most common publication venues for their work are:

  • Human Gene Therapy
  • American Journal of Respiratory and Critical Care Medicine
  • Scientific Reports
  • Molecular Therapy
  • CHEST Journal

Ronald G. Crystal has been recognized as a Member of the Association of American Physicians.

Best Publications

  • Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

    David Lyden;Koichi Hattori;Koichi Hattori;Sergio Dias;Carla Costa

  • Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand

    Beate Heissig;Koichi Hattori;Sergio Dias;Matthias Friedrich

  • Transfer of Genes to Humans: Early Lessons and Obstacles to Success

    Ronald G. Crystal

  • Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution.

    S. I. Rennard;G. Basset;D. Lecossier;K. M. O'Donnell

  • Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage.

    G W Hunninghake;J E Gadek;O Kawanami;V J Ferrans

  • In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

    Melissa A. Rosenfeld;Kunihiko Yoshimura;Bruce C. Trapnell;Koichi Yoneyama

  • A call for transparent reporting to optimize the predictive value of preclinical research

    Story C. Landis;Susan G. Amara;Khusru Asadullah;Chris P. Austin

  • Interstitial Lung Diseases of Unknown Cause: Disorders Characterized by Chronic Inflammation of the Lower Respiratory Tract

    Ronald G. Crystal;Peter B. Bitterman;Stephen I. Rennard;Allan J. Hance

  • Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity.

    Gary W. Hunninghake;Ronald G. Crystal

  • Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo

    Melissa A. Rosenfeld;Wolfgang Siegfried;Kunihiko Yoshimura;Koichi Yoneyama

  • Angiogenesis Gene Therapy Phase I Assessment of Direct Intramyocardial Administration of an Adenovirus Vector Expressing VEGF121 cDNA to Individuals With Clinically Significant Severe Coronary Artery Disease

    Todd K. Rosengart;Leonard Y. Lee;Shailen R. Patel;Timothy A. Sanborn

  • Normal alveolar epithelial lining fluid contains high levels of glutathione.

    A. M. Cantin;S. L. North;R. C. Hubbard;R. G. Crystal

  • Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis.

    R. G. Crystal;N. G. Mcelvaney;N. G. Mcelvaney;M. A. Rosenfeld;Chin-Shyan Chu

  • Interstitial lung diseases of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract (first of two parts).

    Ronald G. Crystal;Peter B. Bitterman;Stephen I. Rennard;Allan J. Hance

  • Idiopathic Pulmonary Fibrosis: Clinical, Histologic, Radiographic, Physiologic, Scintigraphic, Cytologic, and Biochemical Aspects

    Ronald G. Crystal;Jack D. Fulmer;William C. Roberts;Morton L. Moss

  • Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

    Koichi Hattori;Sergio Dias;Beate Heissig;Neil R. Hackett

  • Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.

    Scott T. Avecilla;Koichi Hattori;Beate Heissig;Rafael Tejada

  • Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1 + stem cells from bone-marrow microenvironment

    Koichi Hattori;Beate Heissig;Yan Wu;Sergio Dias

  • Altered chloride ion channel kinetics associated with the delta F508 cystic fibrosis mutation.

    Wilfried Dalemans;Pascal Barbry;Guy Champigny;Sophie Jallat

  • Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes

    David K Jin;Koji Shido;Hans-Georg Kopp;Isabelle Petit

Frequent Co-Authors

Neil R. Hackett
Neil R. Hackett Cornell University
Philip L. Leopold
Philip L. Leopold Cornell University
Shahin Rafii
Shahin Rafii Cornell University
Peter B. Bitterman
Peter B. Bitterman University of Minnesota
Victor J. Ferrans
Victor J. Ferrans National Institutes of Health
James M. Wilson
James M. Wilson University of Pennsylvania
Malcolm A.S. Moore
Malcolm A.S. Moore Memorial Sloan Kettering Cancer Center
Bruce C. Trapnell
Bruce C. Trapnell Cincinnati Children's Hospital Medical Center
G.W. Hunninghake
G.W. Hunninghake University of Iowa
Barry E. Kosofsky
Barry E. Kosofsky Cornell University

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