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Biology and Biochemistry

D-Index
83
Citations
55924
World Ranking
3410
National Ranking
1719

Research.com Recognitions

  • 2007 - OSA Fellows For development of innovative biomedical imaging instruments for studying living animals and their use in answering significant questions in biology.

Overview

Charles P. Lin is affiliated with Harvard University in the United States. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, with significant contributions in molecular biology, immunology, hematology, oncology, and genetics.

The main topics explored by Charles P. Lin include immune cells in cancer, single-cell and spatial transcriptomics, neutrophil, myeloperoxidase and oxidative mechanisms, hematopoietic stem cell transplantation, angiogenesis and VEGF in cancer, immune cell function and interaction, and neuroinflammation and neurodegeneration mechanisms.

Charles P. Lin has published extensively in various scientific venues. Frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Blood, Nature, and the Journal of Neuroinflammation.

  • Live-animal imaging of native haematopoietic stem and progenitor cells (2020, Nature)
  • Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis (2022, Nature Neuroscience)
  • Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin (2021, Nature Communications)
  • Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease (2021, Nature Cardiovascular Research)
  • Pathologic angiogenesis in the bone marrow of humanized sickle cell mice is reversed by blood transfusion (2020, Blood)

Frequent collaborators include Shu-Chi A. Yeh, David T. Scadden, Juwell W. Wu, Yookyung Jung, and Clemens Alt.

Charles P. Lin received the OSA Fellows award in 2007 for the development of innovative biomedical imaging instruments designed for studying living animals and their use in addressing significant biological questions.

Best Publications

  • Optical Coherence Tomography

    David Huang;Eric A. Swanson;Charles P. Lin;Joel S. Schuman

  • Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

    Nicola Aceto;Aditya Bardia;David T. Miyamoto;Maria C. Donaldson

  • Imaging of macular diseases with optical coherence tomography.

    Carmen A. Puliafito;Michael R. Hee;Charles P. Lin;Elias Reichel

  • In vivo retinal imaging by optical coherence tomography

    E. A. Swanson;J. A. Izatt;M. R. Hee;D. Huang

  • Micrometer-Scale Resolution Imaging of the Anterior Eye In Vivo With Optical Coherence Tomography

    Joseph A. Izatt;Michael R. Hee;Eric A. Swanson;Charles P. Lin

  • Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

    Marc H. G. P. Raaijmakers;Siddhartha Mukherjee;Shangqin Guo;Siyi Zhang

  • Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy.

    Conor L. Evans;Eric O. Potma;Mehron Puoris'haag;Daniel Côté

  • Myocardial infarction accelerates atherosclerosis

    Partha Dutta;Gabriel Courties;Ying Wei;Florian Leuschner;Florian Leuschner

  • Quantification of Nerve Fiber Layer Thickness in Normal and Glaucomatous Eyes Using Optical Coherence Tomography: A Pilot Study

    Joel S. Schuman;Michael R. Hee;Carmen A. Puliafito;Carlton Wong

  • Direct measurement of local oxygen concentration in the bone marrow of live animals

    Joel A. Spencer;Francesca Ferraro;Emmanuel Roussakis;Alyssa Klein

  • In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

    Dorothy A. Sipkins;Xunbin Wei;Juwell W. Wu;Judith M. Runnels

  • Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

    Cristina Lo Celso;Heather E. Fleming;Juwell W. Wu;Cher X. Zhao

  • Selective cell targeting with light-absorbing microparticles and nanoparticles

    Costas M. Pitsillides;Edwin K. Joe;Xunbin Wei;R. Rox Anderson

  • Chronic variable stress activates hematopoietic stem cells

    Timo Heidt;Hendrik B Sager;Gabriel Courties;Partha Dutta

  • In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

    Joji Fujisaki;Juwell Wu;Juwell Wu;Alicia L. Carlson;Lev Silberstein

  • Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone

    Robert Sackstein;Jasmeen S Merzaban;Derek W Cain;Nilesh M Dagia

  • Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

    Dongsu Park;Joel A. Spencer;Bong Ihn Koh;Tatsuya Kobayashi

  • Distinct bone marrow blood vessels differentially regulate haematopoiesis

    Tomer Itkin;Shiri Gur-Cohen;Joel A. Spencer;Amir Schajnovitz

  • Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma.

    Yazan Alsayed;Hai Ngo;Judith Runnels;Xavier Leleu

  • Syphilis in China: results of a national surveillance programme

    Zhi Qiang Chen;Guo Cheng Zhang;Xiang Dong Gong;Charles Lin;Charles Lin

Frequent Co-Authors

David T. Scadden
David T. Scadden Harvard University
Irene M. Ghobrial
Irene M. Ghobrial Harvard University
Jeffrey M. Karp
Jeffrey M. Karp Brigham and Women's Hospital
Carmen A. Puliafito
Carmen A. Puliafito University of Southern California
David Huang
David Huang Oregon Health & Science University
Joel S. Schuman
Joel S. Schuman Wills Eye Hospital
Xavier Leleu
Xavier Leleu Harvard University
Andrew L. Kung
Andrew L. Kung Memorial Sloan Kettering Cancer Center
Joseph A. Izatt
Joseph A. Izatt Duke University

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