World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
92
Citations
25274
World Ranking
2252
National Ranking
1210

Research.com Recognitions

  • 1999 - Member of the National Academy of Sciences
  • 1990 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

J. Richard McIntosh is affiliated with the University of Colorado Boulder in the United States. Their research primarily focuses on the dynamics and mechanics of microtubules and mitosis, with significant contributions to biochemistry, genetics, and molecular biology as well as agricultural and biological sciences.

The scientist's work spans several subfields including cell biology, plant science, molecular biology, physiology, and epidemiology. Key topics of research include:

  • Microtubule and mitosis dynamics
  • Plant nutrient uptake and metabolism
  • Cellular transport and secretion
  • Plant molecular biology research
  • Photosynthetic processes and mechanisms
  • Trypanosoma species research and implications
  • Calcium signaling and nucleotide metabolism

Recent publications by J. Richard McIntosh and collaborators demonstrate their ongoing investigations into cellular processes related to microtubule behavior and chromosome segregation. Notable papers include:

  • "Regulation of microtubule dynamics, mechanics and function through the growing tip" (2021) in Nature Reviews Molecular Cell Biology
  • "Mechanisms of microtubule dynamics and force generation examined with computational modeling and electron cryotomography" (2020) in Nature Communications
  • "Mechanisms of chromosome biorientation and bipolar spindle assembly analyzed by computational modeling" (2020) in eLife
  • "Anaphase A" (2021) in Seminars in Cell and Developmental Biology
  • "Distinct regions of the kinesin-5 C-terminal tail are essential for mitotic spindle midzone localization and sliding force" (2023) in Proceedings of the National Academy of Sciences

They have published multiple articles in reputed venues such as eLife, bioRxiv (Cold Spring Harbor Laboratory), PLoS ONE, Nature Reviews Molecular Cell Biology, and Nature Communications.

Frequent collaborators of McIntosh include Nikita B. Gudimchuk, Zachary R. Gergely, Meredith D. Betterton, Dmitrii S. Vinogradov, and Michele H. Jones, each contributing to various aspects of related research projects.

McIntosh's career includes recognition through awards such as membership in the National Academy of Sciences since 1999 and being named a Fellow of the John Simon Guggenheim Memorial Foundation in 1990.

Best Publications

  • The molecular architecture of axonemes revealed by cryoelectron tomography.

    Daniela Nicastro;Cindi Schwartz;Jason Pierson;Richard Gaudette

  • A standardized kinesin nomenclature.

    Carolyn J. Lawrence;R. Kelly Dawe;Karen R. Christie;Don W. Cleveland

  • Golgi Structure in Three Dimensions: Functional Insights from the Normal Rat Kidney Cell

    Mark S. Ladinsky;David N. Mastronarde;J. Richard McIntosh;Kathryn E. Howell

  • Cytoplasmic dynein is localized to kinetochores during mitosis

    C. M. Pfarr;M. Coue;P. M. Grissom;Tom S Hays

  • Three-dimensional ultrastructural analysis of the Saccharomyces cerevisiae mitotic spindle.

    M Winey;C L Mamay;E T O'Toole;D N Mastronarde

  • Production of large numbers of mitotic mammalian cells by use of the reversible microtubule inhibitor Nocodazole: Nocodazole accumulated mitotic cells

    Gary W. Zieve;Deborah Turnbull;J.Michael Mullins;J.Richard McIntosh

  • A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles

    Corey Nislow;Vivian A. Lombillo;Ryoko Kuriyama;J. Richard McIntosh

  • Organellar relationships in the Golgi region of the pancreatic beta cell line, HIT-T15, visualized by high resolution electron tomography

    B J Marsh;D N Mastronarde;K F Buttle;K E Howell

  • Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E.

    Frances R. Putkey;Frances R. Putkey;Thorsten Cramer;Mary K. Morphew;Alain D. Silk;Alain D. Silk

  • Spindle microtubule dynamics in sea urchin embryos: analysis using a fluorescein-labeled tubulin and measurements of fluorescence redistribution after laser photobleaching.

    E D Salmon;R J Leslie;W M Saxton;M L Karow

  • Identification of kinesin in sea urchin eggs, and evidence for its localization in the mitotic spindle.

    J. M. Scholey;M. E. Porter;P. M. Grissom;J. R. McIntosh

  • High-voltage electron tomography of spindle pole bodies and early mitotic spindles in the yeast Saccharomyces cerevisiae.

    Eileen T. O’Toole;Mark Winey;J. Richard McIntosh

  • Force production by disassembling microtubules.

    Ekaterina L. Grishchuk;Maxim I. Molodtsov;Fazly I. Ataullakhanov;J. Richard McIntosh

  • Chromosome-Microtubule Interactions During Mitosis

    J. Richard McIntosh;Ekaterina L. Grishchuk;Robert R. West

  • Kinetochore microtubules in PTK cells.

    K L McDonald;E T O'Toole;D N Mastronarde;J R McIntosh

  • Arrangement of Photosystem II and ATP Synthase in Chloroplast Membranes of Spinach and Pea

    Bertram Daum;Daniela Nicastro;Jotham Austin;J. Richard McIntosh

  • Identification of a microtubule-based cytoplasmic motor in the nematode C. elegans.

    R.J. Lye;M.E. Porter;J.M. Scholey;J.R. McIntosh

  • Activation of the MKK/ERK Pathway during Somatic Cell Mitosis: Direct Interactions of Active ERK with Kinetochores and Regulation of the Mitotic 3F3/2 Phosphoantigen

    P S Shapiro;E Vaisberg;A J Hunt;N S Tolwinski

  • Antibodies to the kinesin motor domain and CENP-E inhibit microtubule depolymerization-dependent motion of chromosomes in vitro.

    V A Lombillo;C Nislow;T J Yen;V I Gelfand

  • Visualization of the structural polarity of microtubules.

    Steven R. Heidemann;J. Richard McIntosh

Frequent Co-Authors

Eileen T. O'Toole
Eileen T. O'Toole University of Colorado Boulder
Keith Gull
Keith Gull University of Oxford
Don W. Cleveland
Don W. Cleveland University of California, San Diego
Thomas H. Giddings
Thomas H. Giddings University of Colorado Boulder
Mark Winey
Mark Winey University of California, Davis
Joseph L. Kirschvink
Joseph L. Kirschvink California Institute of Technology
David S. McKay
David S. McKay Johnson Space Center
Mary E. Porter
Mary E. Porter University of Minnesota
Kent L. McDonald
Kent L. McDonald University of California, Berkeley
Pamela J. Bjorkman
Pamela J. Bjorkman California Institute of Technology

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