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Biology and Biochemistry

D-Index
80
Citations
22252
World Ranking
4094
National Ranking
134

Overview

Dermot Kelleher is affiliated with the University of British Columbia in Canada. Their research spans multiple domains within medicine, focusing primarily on surgery, immunology, gastroenterology, infectious diseases, and molecular biology. The work includes significant contributions to esophageal cancer research and treatment as well as studies on Helicobacter pylori-related gastroenterology.

The recent publications authored or co-authored by Kelleher cover diverse topics related to gastrointestinal pathology, immune response, and cellular mechanisms. Key papers include:

  • The Immune Underpinnings of Barrett's-Associated Adenocarcinogenesis: a Retrial of Nefarious Immunologic Co-Conspirators (2022, Cellular and Molecular Gastroenterology and Hepatology)
  • High Content Imaging of Barrett's-Associated High-Grade Dysplasia Cells After siRNA Library Screening Reveals Acid-Responsive Regulators of Cellular Transitions (2020, Cellular and Molecular Gastroenterology and Hepatology)
  • Combination Therapy Using Inhalable GapmeR and Recombinant ACE2 for COVID-19 (2020, Frontiers in Molecular Biosciences)
  • Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus (2020, UNC Libraries)
  • Editorial: Adaptor Protein Regulation in Immune Signalling (2020, Frontiers in Immunology)

Kelleher's research has been disseminated through several publication venues with multiple contributions in some. The most frequent venues include:

  • Cellular and Molecular Gastroenterology and Hepatology
  • Gastroenterology
  • UNC Libraries
  • Frontiers in Molecular Biosciences
  • Frontiers in Immunology

The scientist has collaborated extensively with several co-authors, reflecting a network of research partnerships. Frequent collaborators are:

  • Shane P. Duggan
  • Omar Abuhussein
  • Aideen Long
  • Navin Kumar Verma
  • Sara Hosseini-Farahabadi

The focal areas of Kelleher's scientific inquiry are distributed among the following main fields of study:

  • Medicine
  • Immunology and Microbiology

Within these broader fields, subfields include:

  • Surgery
  • Immunology
  • Gastroenterology
  • Infectious Diseases
  • Molecular Biology

The main research topics documented involve:

  • Esophageal Cancer Research and Treatment
  • Helicobacter pylori-related gastroenterology studies
  • Esophageal and GI Pathology
  • Gastroesophageal reflux and treatments
  • RNA modifications and cancer
  • Immune Response and Inflammation
  • Pancreatic and Hepatic Oncology Research

Best Publications

  • Multiple common variants for celiac disease influencing immune gene expression

    Patrick C. A. Dubois;Gosia Trynka;Lude Franke;Lude Franke;Karen A. Hunt

  • Newly identified genetic risk variants for celiac disease related to the immune response

    Karen A Hunt;Alexandra Zhernakova;Graham Turner;Graham A R Heap

  • A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

    David A. van Heel;Lude Franke;Karen A. Hunt;Rhian Gwilliam

  • Statistical methods for analysis of high-throughput RNA interference screens

    Amanda Birmingham;Laura M Selfors;Thorsten Forster;David Wrobel

  • International, evidence-based consensus diagnostic criteria for HHV-8–negative/idiopathic multicentric Castleman disease

    David C. Fajgenbaum;Thomas S. Uldrick;Adam Bagg;Dale Frank

  • The neutrophil-activating protein (HP-NAP) of Helicobacter pylori is a protective antigen and a major virulence factor.

    Barbara Satin;Giuseppe Del Giudice;Vittorina Della Bianca;Stefano Dusi

  • Nanodrug applications in photodynamic therapy.

    Edyta Paszko;Carsten Ehrhardt;Mathias O. Senge;Dermot P. Kelleher

  • High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy.

    Richard J. Farrell;Ann Murphy;Aideen Long;Suzanne Donnelly

  • St John's Wort increases expression of P-glycoprotein: Implications for drug interactions

    Martina Hennessy;D Kelleher;J P Spiers;M Barry

  • Distinct MHC class I and II alleles are associated with hepatitis c viral clearance, originating from a single source

    Susan M. McKiernan;Richard Hagan;Michael Curry;George S. A. McDonald

  • Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line.

    B. White;M. Schmidt;C. Murphy;W. Livingstone

  • Idiopathic multicentric Castleman's disease: a systematic literature review

    Amy Y Liu;Christopher S Nabel;Brian S Finkelman;Jason R Ruth

  • Nonfunctionalized nanocrystals can exploit a cell's active transport machinery delivering them to specific nuclear and cytoplasmic compartments.

    Igor Nabiev;Siobhan Mitchell;Anthony Davies;Yvonne Williams

  • MECHANISMS OF STEROID ACTION AND RESISTANCE IN INFLAMMATION Glucocorticoid resistance in inflammatory bowel disease

    R J Farrell;D Kelleher

  • Glucocorticoid resistance in inflammatory bowel disease.

    RJ Farrell;D Kelleher

  • Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low

    R J Farrell;Y Ang;P Kileen;D S O'Briain

  • Protein kinase C and the cytoskeleton.

    Carolyn Keenan;Dermot Kelleher

  • Dominant influence of an HLA‐B27 restricted CD8+ T cell response in mediating HCV clearance and evolution

    Christoph Neumann-Haefelin;Susan McKiernan;Scott Ward;Sergei Viazov

  • NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe?

    I D R Arnott;E R Nimmo;H E Drummond;J Fennell

  • Proinflammatory cytokine and nuclear factor kappa-B expression along the inflammation-metaplasia-dysplasia-adenocarcinoma sequence in the esophagus.

    J M O'Riordan;M M Abdel-latif;N Ravi;D McNamara

Frequent Co-Authors

John V. Reynolds
John V. Reynolds Trinity College Dublin
Cliona O'Farrelly
Cliona O'Farrelly Trinity College Dublin
Conleth Feighery
Conleth Feighery Trinity College Dublin
Colm O'Morain
Colm O'Morain Trinity College Dublin
Thomas J. Ryan
Thomas J. Ryan Cincinnati Children's Hospital Medical Center
Luke A. J. O'Neill
Luke A. J. O'Neill Trinity College Dublin
Paul Klenerman
Paul Klenerman University of Oxford
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen
Derek G. Doherty
Derek G. Doherty Trinity College Dublin
Lude Franke
Lude Franke University Medical Center Groningen

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