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Biology and Biochemistry

D-Index
87
Citations
29859
World Ranking
2810
National Ranking
203

Overview

David A. van Heel is affiliated with Queen Mary University of London in the United Kingdom. Their research spans several interconnected fields, including biochemistry, genetics, molecular biology, and medicine.

The primary areas of focus within their work involve genetics and molecular biology, with specific attention to epidemiology, endocrinology, diabetes and metabolism, and surgery as relevant subfields. Their studies cover a wide range of topics, such as genetic associations and epidemiology, liver disease diagnosis and treatment, epigenetics and DNA methylation, birth, development, and health, diabetes and associated disorders, BRCA gene mutations in cancer, and genetic and phenotypic traits in livestock.

Van Heel has published extensively in notable scientific venues, demonstrating engagement with both preprint and peer-reviewed literature. Their frequent publication outlets include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Genetics
  • Nature Communications
  • Nature
  • Nature Medicine

Some of their recent papers illustrate the scope of their research contributions:

  • Mapping the human genetic architecture of COVID-19, 2021, Nature
  • A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease, 2023, Nature Medicine
  • Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference, 2024, Nature Genetics
  • MC3R links nutritional state to childhood growth and the timing of puberty, 2021, Nature
  • Polygenic prediction of preeclampsia and gestational hypertension, 2023, Nature Medicine

Collaboration appears to be a significant aspect of their research activity. Frequent co-authors include:

  • Sarah Finer
  • Hilary C. Martin
  • Richard C. Trembath
  • Sam Hodgson
  • Karen A. Hunt

The extensive publication record of David A. van Heel in genetics and biomedical sciences positions them centrally in ongoing research efforts addressing complex diseases and genetic epidemiology.

Best Publications

  • Genetic mechanisms of critical illness in Covid-19.

    E. Pairo-Castineira;E. Pairo-Castineira;S. Clohisey;L. Klaric;A. D. Bretherick

  • Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology

    Jonas F Ludvigsson;Jonas F Ludvigsson;Julio C Bai;Federico Biagi;Timothy R Card

  • Multiple common variants for celiac disease influencing immune gene expression

    Patrick C. A. Dubois;Gosia Trynka;Lude Franke;Lude Franke;Karen A. Hunt

  • Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

    Gosia Trynka;Karen A Hunt;Nicholas A Bockett;Jihane Romanos

  • Shared and distinct genetic variants in type 1 diabetes and celiac disease.

    Deborah J. Smyth;Vincent Plagnol;Neil M. Walker;Jason D. Cooper

  • Newly identified genetic risk variants for celiac disease related to the immune response

    Karen A Hunt;Alexandra Zhernakova;Graham Turner;Graham A R Heap

  • A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21

    David A. van Heel;Lude Franke;Karen A. Hunt;Rhian Gwilliam

  • Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

    Ming-Huei Chen;Laura M Raffield;Abdou Mousas;Saori Sakaue

  • Pervasive sharing of genetic effects in autoimmune disease.

    Chris Cotsapas;Benjamin F. Voight;Benjamin F. Voight;Elizabeth Rossin;Kasper Lage;Kasper Lage;Kasper Lage

  • A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

    Nicole Soranzo;Nicole Soranzo;Tim D Spector;Massimo Mangino;Brigitte Kühnel

  • Genetic insights into common pathways and complex relationships among immune-mediated diseases.

    Miles Parkes;Adrian Cortes;David A. van Heel;Matthew A. Brown

  • Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases A Mendelian Randomization Study

    Philip C Haycock;Stephen Burgess;Aayah Nounu

  • Comprehensive, Quantitative Mapping of T Cell Epitopes in Gluten in Celiac Disease

    Jason A. Tye-Din;Jessica A. Stewart;James A. Dromey;Tim Beissbarth

  • Recent advances in coeliac disease

    D A van Heel;J West

  • Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

    Rudolf S. N. Fehrmann;Ritsert C. Jansen;Jan H. Veldink;Harm-Jan Westra

  • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

    Jimmy Z Liu;Johannes Roksund Hov;Trine Folseraas;Trine Folseraas;Eva Ellinghaus

  • Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease.

    David A van Heel;Subrata Ghosh;Matt Butler;Karen A Hunt

  • Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.

    David A. van Heel;Irina A. Udalova;Arjuna P. De Silva;Dermot P. McGovern

  • Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease

    Dermot P.B. McGovern;Pirro Hysi;Tariq Ahmad;David A. van Heel

  • Pervasive Sharing of Genetic Effects in Autoimmune Disease

    Chris Cotsapas;Benjamin F. Voight;Elizabeth Rossin;Kasper Lage

Frequent Co-Authors

Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen
Lude Franke
Lude Franke University Medical Center Groningen
Gosia Trynka
Gosia Trynka Wellcome Sanger Institute
Richard C. Trembath
Richard C. Trembath King's College London
Derek P. Jewell
Derek P. Jewell University of Oxford
Daniel G. MacArthur
Daniel G. MacArthur Garvan Institute of Medical Research
Alexandra Zhernakova
Alexandra Zhernakova University Medical Center Groningen
John Wright
John Wright National Health Service
Rinse K. Weersma
Rinse K. Weersma University Medical Center Groningen
Mark J. Daly
Mark J. Daly Massachusetts General Hospital

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