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Biology and Biochemistry

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54
Citations
21775
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15347
National Ranking
1208

Overview

Gosia Trynka is affiliated with the Wellcome Sanger Institute in the United Kingdom. Their research spans several interconnected fields within Biochemistry, Genetics, and Molecular Biology, with particular emphasis on Immunology and Microbiology.

The main fields of study in their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Immunology and Microbiology

Within these areas, Trynka's primary subfields of study are:

  • Molecular Biology
  • Immunology
  • Genetics
  • Infectious Diseases
  • Neurology

The research topics covered by Trynka highlight a focus on complex cellular and genetic mechanisms, including:

  • Single-cell and spatial transcriptomics
  • Genetic Associations and Epidemiology
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Epigenetics and DNA Methylation
  • RNA and protein synthesis mechanisms
  • Bioinformatics and Genomic Networks

Trynka has contributed to several recent papers, illustrating engagement with cutting-edge research in genetics and immune biology. Notable publications include:

  • From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases (2020, Frontiers in Genetics)
  • Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines (2020, Nature Communications)
  • The single-cell eQTLGen consortium (2020, eLife)
  • Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation (2022, Nature Genetics)
  • Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney (2021, Nature Genetics)

The most frequent publication venues for Trynka's work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Genetics
  • Scientific Reports

Trynka collaborates regularly with a number of co-authors, reflecting a network of researchers specialized in related topics. Frequent co-authors include:

  • Eddie Cano-Gamez
  • Blagoje Soskic
  • Deborah J. Smyth
  • Lara Bossini-Castillo
  • Nikolina Nakić

This body of work situates Gosia Trynka as an active contributor to genetic and immunological research, with a strong focus on the functional implications of genetic variants, immune cell biology, and single-cell technologies.

Best Publications

  • Genetics of rheumatoid arthritis contributes to biology and drug discovery

    Yukinori Okada;Yukinori Okada;Di Wu;Di Wu;Di Wu;Gosia Trynka;Gosia Trynka;Towfique Raj;Towfique Raj

  • Partitioning heritability by functional annotation using genome-wide association summary statistics.

    Hilary K Finucane;Hilary K Finucane;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Alexander Gusev;Gosia Trynka

  • Multiple common variants for celiac disease influencing immune gene expression

    Patrick C. A. Dubois;Gosia Trynka;Lude Franke;Lude Franke;Karen A. Hunt

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    Lam C. Tsoi;Sarah L. Spain;Sarah L. Spain;Jo Knight;Eva Ellinghaus;Eva Ellinghaus

  • Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

    Gosia Trynka;Karen A Hunt;Nicholas A Bockett;Jihane Romanos

  • Newly identified genetic risk variants for celiac disease related to the immune response

    Karen A Hunt;Alexandra Zhernakova;Graham Turner;Graham A R Heap

  • High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

    Steve Eyre;John Bowes;John Bowes;Dorothée Diogo;Dorothée Diogo;Annette Lee

  • Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

    Alexander Gusev;S. Hong Lee;Gosia Trynka;Hilary Finucane

  • Chromatin marks identify critical cell types for fine mapping complex trait variants

    Gosia Trynka;Cynthia Sandor;Buhm Han;Han Xu;Han Xu

  • Fine-mapping inflammatory bowel disease loci to single-variant resolution

    Hailiang Huang;Hailiang Huang;Ming Fang;Luke Jostins;Maša Umićević Mirkov

  • Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

    Eli A Stahl;Daniel Wegmann;Gosia Trynka;Javier Gutierrez-Achury

  • From GWAS to Function: Using Functional Genomics to Identify the Mechanisms Underlying Complex Diseases.

    Eddie Cano-Gamez;Gosia Trynka

  • Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

    Alexandra Zhernakova;Alexandra Zhernakova;Alexandra Zhernakova;Eli A. Stahl;Eli A. Stahl;Gosia Trynka;Soumya Raychaudhuri

  • Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.

    Rudolf S. N. Fehrmann;Ritsert C. Jansen;Jan H. Veldink;Harm-Jan Westra

  • Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP.

    Alexandra Zhernakova;Eleanora M. Festen;Lude Franke;Lude Franke;Gosia Trynka

  • Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

    Louise V. Wain;Louise V. Wain;Nick Shrine;María Soler Artigas;A. Mesut Erzurumluoglu

  • The influence of a short-term gluten-free diet on the human gut microbiome

    Marc Jan Bonder;Ettje F. Tigchelaar;Xianghang Cai;Gosia Trynka

  • A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease

    Eleonora A. M. Festen;Philippe Goyette;Todd Green;Gabrielle Boucher

  • Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

    Alexandra Zhernakova;Alexandra Zhernakova;Alexandra Zhernakova;Eli A. Stahl;Eli A. Stahl;Gosia Trynka;Soumya Raychaudhuri;Soumya Raychaudhuri

  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

    L. C. Tsoi;S. L. Spain;J. Knight;E. Ellinghaus

Frequent Co-Authors

Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen
Lude Franke
Lude Franke University Medical Center Groningen
Alexandra Zhernakova
Alexandra Zhernakova University Medical Center Groningen
Soumya Raychaudhuri
Soumya Raychaudhuri Brigham and Women's Hospital
David A. van Heel
David A. van Heel Queen Mary University of London
Eli A. Stahl
Eli A. Stahl Icahn School of Medicine at Mount Sinai
Robert M. Plenge
Robert M. Plenge Bristol Myers Squibb
Rinse K. Weersma
Rinse K. Weersma University Medical Center Groningen
Jane Worthington
Jane Worthington University of Manchester
Roel A. Ophoff
Roel A. Ophoff University of California, Los Angeles

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