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D-Index & Metrics

Molecular Biology

D-Index
46
Citations
24550
World Ranking
2767
National Ranking
1332

Shengdar Q. Tsai publication distribution in Molecular Biology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Molecular Biology in 2026. The highlighted bar marks where Shengdar Q. Tsai sits on this spectrum.

47–56 publications: 7 scientists 57–66 publications: 17 scientists 67–76 publications: 65 scientists 77–86 publications: 90 scientists 87–96 publications: 125 scientists 97–106 publications: 131 scientists 107–116 publications: 162 scientists 117–126 publications: 177 scientists 127–136 publications: 158 scientists 137–146 publications: 158 scientists 147–156 publications: 146 scientists 157–166 publications: 159 scientists 167–176 publications: 131 scientists 177–186 publications: 110 scientists 187–196 publications: 112 scientists 197–206 publications: 100 scientists 207–216 publications: 89 scientists 217–226 publications: 98 scientists 227–236 publications: 74 scientists 237–246 publications: 72 scientists 247–256 publications: 63 scientists 257–266 publications: 53 scientists 267–276 publications: 54 scientists 277–286 publications: 49 scientists 287–296 publications: 52 scientists 297–306 publications: 43 scientists 307–316 publications: 46 scientists 317–326 publications: 41 scientists 327–336 publications: 42 scientists 337–346 publications: 31 scientists 347–356 publications: 28 scientists 357–366 publications: 29 scientists 367–376 publications: 26 scientists 377–386 publications: 24 scientists 387–396 publications: 24 scientists 397–406 publications: 14 scientists 407–416 publications: 13 scientists 417–426 publications: 20 scientists 427–436 publications: 12 scientists 437–446 publications: 20 scientists 447–456 publications: 11 scientists 457–466 publications: 10 scientists 467–476 publications: 14 scientists 477–486 publications: 14 scientists 487–496 publications: 10 scientists 497–506 publications: 13 scientists 507–516 publications: 13 scientists 517–526 publications: 2 scientists 527–536 publications: 4 scientists 537–546 publications: 6 scientists 547–556 publications: 8 scientists 557–563 publications: 6 scientists 564+ publications: 100 scientists
47 publications 564+

This scientist: 129 publications — 27th percentile

27% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 564 publications or more.

Shengdar Q. Tsai D-index placement in Molecular Biology in 2026

The chart shows the D-index (discipline H-index) distribution of Molecular Biology scientists ranked by Research.com in 2026. The highlighted bar marks where Shengdar Q. Tsai sits on this spectrum.

40–41 D-Index: 36 scientists 42–43 D-Index: 101 scientists 44–45 D-Index: 115 scientists 46–47 D-Index: 121 scientists 48–49 D-Index: 118 scientists 50–51 D-Index: 130 scientists 52–53 D-Index: 106 scientists 54–55 D-Index: 116 scientists 56–57 D-Index: 113 scientists 58–59 D-Index: 129 scientists 60–61 D-Index: 120 scientists 62–63 D-Index: 105 scientists 64–65 D-Index: 131 scientists 66–67 D-Index: 95 scientists 68–69 D-Index: 97 scientists 70–71 D-Index: 106 scientists 72–73 D-Index: 83 scientists 74–75 D-Index: 89 scientists 76–77 D-Index: 77 scientists 78–79 D-Index: 70 scientists 80–81 D-Index: 73 scientists 82–83 D-Index: 60 scientists 84–85 D-Index: 48 scientists 86–87 D-Index: 45 scientists 88–89 D-Index: 50 scientists 90–91 D-Index: 31 scientists 92–93 D-Index: 51 scientists 94–95 D-Index: 43 scientists 96–97 D-Index: 38 scientists 98–99 D-Index: 39 scientists 100–101 D-Index: 41 scientists 102–103 D-Index: 29 scientists 104–105 D-Index: 33 scientists 106–107 D-Index: 35 scientists 108–109 D-Index: 20 scientists 110–111 D-Index: 38 scientists 112–113 D-Index: 19 scientists 114–115 D-Index: 28 scientists 116–117 D-Index: 13 scientists 118–119 D-Index: 23 scientists 120–121 D-Index: 16 scientists 122–123 D-Index: 15 scientists 124–125 D-Index: 11 scientists 126–127 D-Index: 21 scientists 128–129 D-Index: 7 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 14 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 9 scientists 138–139 D-Index: 8 scientists 140–141 D-Index: 16 scientists 142–143 D-Index: 7 scientists 144 D-Index: 7 scientists 145+ D-Index: 100 scientists
40 D-Index 145+

This scientist: 46 D-Index — 10th percentile

10% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 145 D-Index or more.

Overview

Shengdar Q. Tsai is affiliated with St. Jude Children's Research Hospital in the United States and specializes mainly in biochemistry, genetics, and molecular biology. Their work spans multiple fields within medicine, with significant contributions to molecular biology, genetics, oncology, immunology, and pediatrics.

The research of Shengdar Q. Tsai largely focuses on genetic engineering and gene-editing technologies, particularly employing CRISPR methodologies. The main topics covered in their publications include:

  • CRISPR and Genetic Engineering
  • CAR-T cell therapy research
  • Hemoglobinopathies and Related Disorders
  • Virus-based gene therapy research
  • Prenatal Screening and Diagnostics
  • Immune Cell Function and Interaction
  • RNA modifications and cancer

Tsai has collaborated frequently with several co-authors over multiple publications. Notable frequent collaborators include Cícera R. Lazzarotto, Varun Katta, Yichao Li, Mitchell J. Weiss, and Jonathan Yen.

Their research outputs have appeared in a variety of scientific journals and preprint servers. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Nature
  • Nature Genetics
  • Nature Biomedical Engineering

Among the recent papers authored or co-authored by Tsai are:

  • Base editing of haematopoietic stem cells rescues sickle cell disease in mice, 2021, Nature
  • Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity, 2021, Science Translational Medicine
  • CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity, 2020, Nature Biotechnology
  • The NIH Somatic Cell Genome Editing program, 2021, Nature
  • Human genetic diversity alters off-target outcomes of therapeutic gene editing, 2022, Nature Genetics

Best Publications

  • Efficient genome editing in zebrafish using a CRISPR-Cas system

    Woong Y. Hwang;Yanfang Fu;Deepak Reyon;Morgan L. Maeder

  • High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

    Benjamin P. Kleinstiver;Vikram Pattanayak;Michelle S. Prew;Shengdar Q. Tsai

  • GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

    Shengdar Q Tsai;Zongli Zheng;Nhu T Nguyen;Matthew Liebers

  • Engineered CRISPR-CAS9 nucleases with altered PAM specificity

    J. Keith Joung;Benjamin Kleinstiver

  • FLASH assembly of TALENs for high-throughput genome editing

    Deepak Reyon;Shengdar Q Tsai;Cyd Khayter;Jennifer A Foden

  • Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

    Shengdar Q Tsai;Nicolas Wyvekens;Cyd Khayter;Jennifer A Foden

  • CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets

    Shengdar Q Tsai;Nhu T Nguyen;Jose Malagon-Lopez;Ved V Topkar

  • Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

    Benjamin P Kleinstiver;Shengdar Q Tsai;Michelle S Prew;Nhu T Nguyen

  • Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

    Benjamin P Kleinstiver;Michelle S Prew;Shengdar Q Tsai;Nhu T Nguyen

  • Toddler: an embryonic signal that promotes cell movement via Apelin receptors.

    Andrea Pauli;Megan L. Norris;Eivind Valen;Guo-Liang Chew

  • Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

    Morgan L Maeder;James F Angstman;Marcy E Richardson;Samantha J Linder

  • Targeted disruption of DNMT1 , DNMT3A and DNMT3B in human embryonic stem cells

    Jing Liao;Rahul Karnik;Hongcang Gu;Michael J Ziller

  • Defining and improving the genome-wide specificities of CRISPR-Cas9 nucleases

    Shengdar Q. Tsai;J. Keith Joung

  • Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

    Miriam Y. Kim;Kyung Rok Yu;Saad S. Kenderian;Marco Ruella

  • Highly efficient therapeutic gene editing of human hematopoietic stem cells.

    Yuxuan Wu;Jing Zeng;Jing Zeng;Benjamin P. Roscoe;Pengpeng Liu

  • High levels of AAV vector integration into CRISPR-induced DNA breaks

    Killian S. Hanlon;Benjamin P. Kleinstiver;Sara P. Garcia;Mikołaj P. Zaborowski;Mikołaj P. Zaborowski

  • In vivo CRISPR editing with no detectable genome-wide off-target mutations

    Pinar Akcakaya;Maggie L. Bobbin;Jimmy A. Guo;Jose Malagon-Lopez

  • Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs

    Lindsay Cade;Deepak Reyon;Woong Y. Hwang;Shengdar Q. Tsai

  • Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity

    John P Guilinger;Vikram Pattanayak;Deepak Reyon;Shengdar Q Tsai

  • 731. High-Fidelity CRISPR-Cas9 Nucleases with No Detectable Genome-Wide Off-Target Effects

    Benjamin P. Kleinstiver;Vikram Pattanayak;Michelle S. Prew;Shengdar Q. Tsai

Frequent Co-Authors

J. Keith Joung
J. Keith Joung Harvard University
David R. Liu
David R. Liu Broad Institute
Martin J. Aryee
Martin J. Aryee Harvard University
John F. Tisdale
John F. Tisdale National Institutes of Health
Daniel E. Bauer
Daniel E. Bauer Harvard University
Scot A. Wolfe
Scot A. Wolfe University of Massachusetts Chan Medical School
Mitchell J. Weiss
Mitchell J. Weiss St. Jude Children's Research Hospital
Alexander F. Schier
Alexander F. Schier University of Basel
Robert E. Donahue
Robert E. Donahue National Institutes of Health
John P. Manis
John P. Manis Boston Children's Hospital

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