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Genetics

D-Index
67
Citations
47216
World Ranking
2470
National Ranking
1108

Overview

Martin J. Aryee is affiliated with Harvard University in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work is concentrated primarily within subfields such as molecular biology, cancer research, immunology, oncology, and genetics.

The scientist's research topics include:

  • Genomics and chromatin dynamics
  • Single-cell and spatial transcriptomics
  • Epigenetics and DNA methylation
  • Cancer genomics and diagnostics
  • RNA research and splicing
  • RNA modifications and cancer
  • CRISPR and genetic engineering

Recent papers authored or co-authored by Martin J. Aryee cover a range of high-impact studies published in notable scientific venues. Important publications include:

  • "Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment" (2022, Nature Genetics)
  • "Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling" (2020, Nature Biotechnology)
  • "Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer" (2020, Cell)
  • "A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing" (2020, Nature Biotechnology)
  • "STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma" (2021, Cancer Cell)

Frequent publication venues for Aryee's work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Biotechnology
  • Blood
  • Cell

Collaborative research is a significant aspect of Aryee's career, with frequent co-authors being:

  • David T. Ting
  • Michael J. Raabe
  • Linda T. Nieman
  • Katherine Xu
  • Bidish K. Patel

Martin J. Aryee's research aligns with advancing understanding in the interplay of genetic and epigenetic factors influencing cancer and other medical fields through innovative single-cell and CRISPR technologies. Their multidisciplinary approach integrates molecular biology techniques with clinical research efforts to contribute to evolving diagnostics and therapeutic strategies.

Best Publications

  • A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

    Stephen S. Lim;Theo Vos;Abraham D. Flaxman;Goodarz Danaei

  • Minfi: A flexible and comprehensive Bioconductor package for the analysis of Infinium DNA Methylation microarrays

    Martin J. Aryee;Andrew E. Jaffe;Hector Corrada-Bravo;Christine Ladd-Acosta

  • Epigenetic memory in induced pluripotent stem cells

    K. Kim;A. Doi;B. Wen;K. Ng

  • GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

    Shengdar Q Tsai;Zongli Zheng;Nhu T Nguyen;Matthew Liebers

  • Engineered CRISPR-CAS9 nucleases with altered PAM specificity

    J. Keith Joung;Benjamin Kleinstiver

  • Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.

    Akiko Doi;In Hyun Park;Bo Wen;Peter Murakami

  • Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

    Shengdar Q Tsai;Nicolas Wyvekens;Cyd Khayter;Jennifer A Foden

  • Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

    Yun Liu;Martin J Aryee;Leonid Padyukov;M Daniele Fallin;M Daniele Fallin

  • Global Causes of Diarrheal Disease Mortality in Children <5 Years of Age: A Systematic Review

    Claudio F. Lanata;Christa L. Fischer-Walker;Ana C. Olascoaga;Carla X. Torres

  • Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

    Hong Ji;Lauren Ilyse richie Ehrlich;Jun Seita;Peter Murakami

  • CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets

    Shengdar Q Tsai;Nhu T Nguyen;Jose Malagon-Lopez;Ved V Topkar

  • Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

    Kitai Kim;Kitai Kim;Rui Zhao;Akiko Doi;Kitwa Ng

  • Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells

    Benjamin P Kleinstiver;Shengdar Q Tsai;Michelle S Prew;Nhu T Nguyen

  • Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.

    Benjamin P. Kleinstiver;Alexander A. Sousa;Russell T. Walton;Y. Esther Tak

  • Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

    Michael C Haffner;Martin J Aryee;Antoun Toubaji;David M Esopi

  • Diarrhea incidence in low- and middle-income countries in 1990 and 2010: a systematic review

    Christa L Fischer Walker;Jamie Perin;Martin J Aryee;Cynthia Boschi-Pinto

  • Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation

    Jason D. Buenrostro;Jason D. Buenrostro;M. Ryan Corces;Caleb A. Lareau;Caleb A. Lareau;Beijing Wu

  • Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

    Julian Grünewald;Ronghao Zhou;Sara P. Garcia;Sowmya Iyer

  • Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

    Matteo Ligorio;Srinjoy Sil;Jose Malagon-Lopez;Linda T. Nieman

  • Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics.

    Leif S. Ludwig;Leif S. Ludwig;Caleb A. Lareau;Jacob C. Ulirsch;Elena Christian

Frequent Co-Authors

J. Keith Joung
J. Keith Joung Harvard University
Rafael A. Irizarry
Rafael A. Irizarry Harvard University
Andrew P. Feinberg
Andrew P. Feinberg Johns Hopkins University
Jason D. Buenrostro
Jason D. Buenrostro Harvard University
Shengdar Q. Tsai
Shengdar Q. Tsai St. Jude Children's Research Hospital
Bradley E. Bernstein
Bradley E. Bernstein Broad Institute
Vijay G. Sankaran
Vijay G. Sankaran Harvard University
Srinivasan Yegnasubramanian
Srinivasan Yegnasubramanian Johns Hopkins University School of Medicine
Aviv Regev
Aviv Regev Genentech
David T. Ting
David T. Ting Harvard University

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