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Molecular Biology

D-Index
63
Citations
16307
World Ranking
1793
National Ranking
896

Overview

Srinivasan Yegnasubramanian is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans across Medicine and Biochemistry, Genetics and Molecular Biology, with a strong focus on Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Immunology, and Cancer Research.

Their recent academic output includes significant contributions published in prominent venues such as Nature, Nature Reviews Urology, Cell Reports, and the Journal of Clinical Investigation. Notable papers include:

  • Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers (2021, Nature)
  • Genomic and phenotypic heterogeneity in prostate cancer (2020, Nature Reviews Urology)
  • Metabolic programs define dysfunctional immune responses in severe COVID-19 patients (2021, Cell Reports)
  • A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target (2020, Journal of Clinical Investigation)
  • Functional characterization of CD4+ T cell receptors crossreactive for SARS-CoV-2 and endemic coronaviruses (2021, Journal of Clinical Investigation)

Yegnasubramanian's research interests focus predominantly on prostate cancer treatment and research, cancer immunotherapy and biomarkers, cancer genomics and diagnostics, epigenetics and DNA methylation, immune cells in cancer, immunotherapy and immune responses, and CAR-T cell therapy research.

Frequent co-authors who have collaborated extensively with Yegnasubramanian include:

  • Angelo M. De Marzo
  • William G. Nelson
  • Jessica Hicks
  • Rulin Wang
  • Ajay Vaghasia

The scientist has regularly published in several key journals and preprint servers. Their most frequent publication venues are:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Prostate
  • JCI Insight
  • Nature Communications

Their work intersects multiple disciplines, with 176 publications classified under Medicine and 115 publications in Biochemistry, Genetics and Molecular Biology. Subfields prominently represented include 72 in Molecular Biology, 51 in Oncology, 49 in Pulmonary and Respiratory Medicine, 44 in Immunology, and 35 in Cancer Research.

This comprehensive research portfolio illustrates a focus on molecular mechanisms and clinical applications related to cancer and immune responses, contributing to the broader understanding of oncology and immunology through interdisciplinary approaches.

Best Publications

  • Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

    Wennuan Liu;Sari Laitinen;Sofia Khan;Mauno Vihinen

  • Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

    Michael C Haffner;Martin J Aryee;Antoun Toubaji;David M Esopi

  • Distinct Transcriptional Programs Mediated by the Ligand-Dependent Full-Length Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer

    Rong Hu;Changxue Lu;Elahe A. Mostaghel;Srinivasan Yegnasubramanian

  • Hypermethylation of CpG Islands in Primary and Metastatic Human Prostate Cancer

    Srinivasan Yegnasubramanian;Jeanne Kowalski;Mark L. Gonzalgo;Marianna Zahurak

  • Tracking the clonal origin of lethal prostate cancer.

    Michael C. Haffner;Timothy Mosbruger;David M. Esopi;Helen Fedor

  • miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth.

    Judit Ribas;Xiaohua Ni;Michael Haffner;Erik A. Wentzel

  • Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers

    Michael C Haffner;Alcides Chaux;Alan K. Meeker;David M Esopi

  • The inflammatory microenvironment and microbiome in prostate cancer development

    Karen S. Sfanos;Srinivasan Yegnasubramanian;William G. Nelson;Angelo M. De Marzo

  • Loss of Kelch-Like ECH-Associated Protein 1 Function in Prostate Cancer Cells Causes Chemoresistance and Radioresistance and Promotes Tumor Growth

    Ping Zhang;Anju Singh;Srinivasan Yegnasubramanian;David Esopi

  • Update on Systemic Prostate Cancer Therapies: Management of Metastatic Castration-resistant Prostate Cancer in the Era of Precision Oncology.

    Philipp Nuhn;Johann S. De Bono;Karim Fizazi;Stephen J. Freedland;Stephen J. Freedland

  • Procainamide is a specific inhibitor of DNA methyltransferase 1.

    Byron H. Lee;Srinivasan Yegnasubramanian;Xiaohui Lin;William G. Nelson

  • MYC and Prostate Cancer

    Cheryl M. Koh;Charles J. Bieberich;Chi V. Dang;William G. Nelson

  • Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers.

    Justina X. Caushi;Jiajia Zhang;Zhicheng Ji;Zhicheng Ji;Ajay Vaghasia

  • Genomic and phenotypic heterogeneity in prostate cancer.

    Michael C. Haffner;Michael C. Haffner;Michael C. Haffner;Wilbert Zwart;Martine P. Roudier;Lawrence D. True

  • DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity

    Srinivasan Yegnasubramanian;Michael C. Haffner;Yonggang Zhang;Bora Gurel

  • GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer.

    Masashi Nakayama;Mark L. Gonzalgo;Srinivasan Yegnasubramanian;Xiaohui Lin

  • A DNA hypermethylation module for the stem/progenitor cell signature of cancer

    Hariharan Easwaran;Sarah E. Johnstone;Leander Van Neste;Joyce Ohm

  • DNA Methylation Alterations Exhibit Intraindividual Stability and Interindividual Heterogeneity in Prostate Cancer Metastases

    Martin J. Aryee;Wennuan Liu;Julia C. Engelmann;Philipp Nuhn

  • Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: Results from a pilot clinical study

    Michael T. Schweizer;Emmanuel S. Antonarakis;Hao Wang;A. Seun Ajiboye

  • Abstract LB-174: A DNA hypermethylation module for the stem/progenitor cell signature of cancer

    Hariharan Easwaran;Sarah E. Johnstone;Leander Van Neste;Joyce E. Ohm

Frequent Co-Authors

William G. Nelson
William G. Nelson Johns Hopkins University School of Medicine
Angelo M. De Marzo
Angelo M. De Marzo Johns Hopkins University School of Medicine
William B. Isaacs
William B. Isaacs Johns Hopkins University
Sarah J. Wheelan
Sarah J. Wheelan Johns Hopkins University School of Medicine
George J. Netto
George J. Netto University of Alabama at Birmingham
Alan K. Meeker
Alan K. Meeker Johns Hopkins University School of Medicine
Martin J. Aryee
Martin J. Aryee Harvard University
Bruce J. Trock
Bruce J. Trock Johns Hopkins University
Mario A. Eisenberger
Mario A. Eisenberger Johns Hopkins University
Bert Vogelstein
Bert Vogelstein Johns Hopkins University

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