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Medicine

D-Index
78
Citations
24819
World Ranking
17969
National Ranking
8958

Overview

Alan K. Meeker is affiliated with Johns Hopkins University School of Medicine in the United States. Their research encompasses a range of topics primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Subfields of study include Molecular Biology, Pulmonary and Respiratory Medicine, Physiology, Genetics, and Immunology.

Their work covers main research themes such as Telomeres, Telomerase, and Senescence; Prostate Cancer Treatment and Research; Glioma Diagnosis and Treatment; Xenotransplantation and Immune Response; Peptidase Inhibition and Analysis; Epigenetics and DNA Methylation; and Protease and Inhibitor Mechanisms.

Alan K. Meeker has published frequently in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Prostate
  • Cancer Research
  • Oncogene
  • Molecular Cancer Research

Frequent collaborators include Angelo M. De Marzo, Christopher M. Heaphy, Tamara L. Lotan, Corinne E. Joshu, and William G. Nelson.

Notable recent publications include:

  • Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors (2020, Oncogene)
  • ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization (2022, Cell Reports)
  • Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer (2021, JCI Insight)
  • Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer (2021, Proceedings of the National Academy of Sciences)
  • LY6S, a New IFN-Inducible Human Member of the Ly6a Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance (2022, ImmunoHorizons)

Best Publications

  • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

    Patrick J. Killela;Zachary J. Reitman;Yuchen Jiao;Chetan Bettegowda

  • Altered Telomeres in Tumors with ATRX and DAXX Mutations

    Christopher M. Heaphy;Roeland F. de Wilde;Yuchen Jiao;Alison P. Klein

  • Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

    Michael C Haffner;Martin J Aryee;Antoun Toubaji;David M Esopi

  • Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.

    Yuchen Jiao;Patrick J. Killela;Zachary J. Reitman;B Ahmed Rasheed

  • Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.

    Courtney A. Lovejoy;Wendi Li;Steven Reisenweber;Supawat Thongthip

  • Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes.

    Christopher M. Heaphy;Andrea P. Subhawong;Seung Mo Hong;Michael G. Goggins

  • Telomerase activity: a prevalent marker of malignant human prostate tissue.

    Hans Joerg Sommerfeld;Alan K. Meeker;Mieczyslaw A. Piatyszek;G. Steven Bova

  • Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease

    David Shortle;Wesley E. Stites;Alan K. Meeker

  • Phenotypic Analysis of Prostate-Infiltrating Lymphocytes Reveals TH17 and Treg Skewing

    Karen Sandell Sfanos;Tullia C. Bruno;Charles H. Maris;Lauren Xu

  • Tracking the clonal origin of lethal prostate cancer.

    Michael C. Haffner;Timothy Mosbruger;David M. Esopi;Helen Fedor

  • Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers

    Michael C Haffner;Alcides Chaux;Alan K. Meeker;David M Esopi

  • TERT PROMOTER MUTATIONS OCCUR FREQUENTLY IN GLIOMAS AND A SUBSET OF TUMORS DERIVED FROM CELLS WITH LOW RATES OF SELF-RENEWAL

    Hai Yan;P.J. Killela;Z.J. Reitman;Y. Jiao

  • Telomere shortening is nearly universal in pancreatic intraepithelial neoplasia.

    N. Tjarda van Heek;N. Tjarda van Heek;Alan K. Meeker;Scott E. Kern;Charles J. Yeo

  • Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis.

    Alan K. Meeker;Jessica L. Hicks;Christine A. Iacobuzio-Donahue;Elizabeth A. Montgomery

  • Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation.

    David Shortle;Alan K. Meeker

  • Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

    Lynnette R. Ferguson;Helen Chen;Andrew R. Collins;Marisa Connell

  • Human prostate-infiltrating CD8+ T lymphocytes are oligoclonal and PD-1+.

    Karen S. Sfanos;Tullia C. Bruno;Alan K. Meeker;Alan K. Meeker;Angelo M. De Marzo;Angelo M. De Marzo

  • PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas

    Ashley Cimino-Mathews;Elizabeth Thompson;Janis M. Taube;Xiaobu Ye

  • Residual structure in large fragments of staphylococcal nuclease: effects of amino acid substitutions.

    David Shortle;Alan K. Meeker

  • Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis

    Alan K Meeker;Jessica L Hicks;Elizabeth A Platz;Gerrun E March

Frequent Co-Authors

Angelo M. De Marzo
Angelo M. De Marzo Johns Hopkins University School of Medicine
George J. Netto
George J. Netto University of Alabama at Birmingham
Elizabeth A. Platz
Elizabeth A. Platz Johns Hopkins University
William G. Nelson
William G. Nelson Johns Hopkins University School of Medicine
Pedram Argani
Pedram Argani Johns Hopkins University
William B. Isaacs
William B. Isaacs Johns Hopkins University
Charles G. Eberhart
Charles G. Eberhart Johns Hopkins University School of Medicine
Charles G. Drake
Charles G. Drake Columbia University
Ralph H. Hruban
Ralph H. Hruban Johns Hopkins University School of Medicine
Srinivasan Yegnasubramanian
Srinivasan Yegnasubramanian Johns Hopkins University School of Medicine

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