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Molecular Biology
USA
2026
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Genetics and Molecular Biology
USA
2024

D-Index & Metrics

Molecular Biology

D-Index
164
Citations
108907
World Ranking
55
National Ranking
37

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award

Overview

Jerry W. Shay is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research contributions span biochemistry, genetics, and molecular biology, with significant intersections in medicine. Shay's work concentrates on molecular biology, physiology, immunology, oncology, and biotechnology, reflecting a multidisciplinary approach across related fields.

The scientist has published extensively on several topics, including:

  • Telomeres, Telomerase, and Senescence
  • RNA modifications and cancer
  • Cancer Research and Treatments
  • Interferon and immune responses
  • DNA Repair Mechanisms
  • Immunotherapy and Immune Responses
  • RNA Research and Splicing

Key publications illustrate the focus on cellular mechanisms affecting cancer and immunity. Notable recent papers include:

  • "MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway," 2020, Cancer Cell
  • "Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity," 2020, Cancer Cell
  • "Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma," 2020, European Journal of Cancer
  • "The cholesterol uptake regulator PCSK9 promotes and is a therapeutic target in APC/KRAS-mutant colorectal cancer," 2022, Nature Communications
  • "Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase," 2020, Journal of Biological Chemistry

Their frequent coauthors include Silvia Siteni, Ilgen Mender, John D. Minna, Beatriz M. A. Fontoura, and Enzo Tedone, reflecting ongoing collaborative efforts in related biomedical fields.

Jerry W. Shay's research is often published in several leading venues, with repeated contributions in:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Cancers
  • Regular and Young Investigator Award Abstracts

Overall, the scientist's extensive output across molecular biology and cancer research demonstrates a consistent focus on telomere biology, immune responses, and mechanisms of cancer at the molecular level. This body of work supports multiple research themes within biochemistry, genetics, and medicine, contributing to understanding disease mechanisms and potential therapeutic strategies.

Best Publications

  • Specific association of human telomerase activity with immortal cells and cancer

    Nam W. Kim;Mieczyslaw A. Piatyszek;Karen R. Prowse;Calvin B. Harley

  • EXTENSION OF LIFE-SPAN BY INTRODUCTION OF TELOMERASE INTO NORMAL HUMAN CELLS

    Andrea G. Bodnar;Michel Ouellette;Maria Frolkis;Shawn E. Holt

  • A survey of telomerase activity in human cancer

    Jerry W Shay;S. Bacchetti

  • BRAFE600-associated senescence-like cell cycle arrest of human naevi

    Chrysiis Michaloglou;Liesbeth C. W. Vredeveld;Maria S. Soengas;Christophe Denoyelle

  • Telomerase activity in human germline and embryonic tissues and cells

    Woodring E. Wright;Mieczyslaw A. Piatyszek;William E. Rainey;William Byrd

  • Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

    Scott L. Weinrich;Ron Pruzan;Libin Ma;Michel Ouellette

  • Human Telomerase and Its Regulation

    Yu Sheng Cong;Woodring E. Wright;Jerry W. Shay

  • Activation of telomerase in human lymphocytes and hematopoietic progenitor cells

    K Hiyama;Y Hirai;S Kyoizumi;M Akiyama

  • Hayflick, his limit, and cellular ageing

    Jerry W. Shay;Woodring E. Wright

  • A transcriptionally active DNA-binding site for human p53 protein complexes.

    Walter D. Funk;Daniel T. Pak;Richard H. Karas;Woodring E. Wright

  • Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

    Carmela P. Morales;Shawn E. Holt;Michel M Ouellette;Kiran J. Kaur

  • Adult-onset pulmonary fibrosis caused by mutations in telomerase

    Kalliopi D. Tsakiri;Jennifer T. Cronkhite;Phillip J. Kuan;Chao Xing

  • A role for both RB and p53 in the regulation of human cellular senescence

    Jerry W. Shay;Olivia M. Pereira-Smith;Woodring E. Wright

  • Normal human chromosomes have long G-rich telomeric overhangs at one end

    Woodring E. Wright;Valerie M. Tesmer;Kenneth E. Huffman;Stephen D. Levene

  • Senescence and immortalization: role of telomeres and telomerase

    Jerry W. Shay;Woodring E. Wright

  • Correlating telomerase activity levels with human neuroblastoma outcomes

    Eiso Hiyama;Keiko Hiyama;Takashi Yokoyama;Yuichiro Matsuura

  • Functional requirement of p23 and Hsp90 in telomerase complexes

    Shawn E. Holt;Shawn E. Holt;Dara L. Aisner;Joseph Baur;Valerie M. Tesmer

  • Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death

    B. S. Herbert;A. E. Pitts;S. I. Baker;S. E. Hamilton

  • Telomerase and cancer

    Jerry W. Shay;Ying Zou;Eiso Hiyama;Woodring E. Wright

  • Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

    Mohammad A. Jafri;Shakeel A. Ansari;Mohammed H. Alqahtani;Jerry W. Shay;Jerry W. Shay

Frequent Co-Authors

Woodring E. Wright
Woodring E. Wright The University of Texas Southwestern Medical Center
John D. Minna
John D. Minna The University of Texas Southwestern Medical Center
Adi F. Gazdar
Adi F. Gazdar The University of Texas Southwestern Medical Center
Sergei M. Gryaznov
Sergei M. Gryaznov MAIA Biotechnology, Inc.
Tej K. Pandita
Tej K. Pandita Houston Methodist
Luc Girard
Luc Girard The University of Texas Southwestern Medical Center
Steven M. Dubinett
Steven M. Dubinett University of California, Los Angeles
Ignacio I. Wistuba
Ignacio I. Wistuba The University of Texas MD Anderson Cancer Center
Elizabeth H. Blackburn
Elizabeth H. Blackburn University of California, San Francisco
Raj K. Pandita
Raj K. Pandita Houston Methodist

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