World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
11342
World Ranking
12081
National Ranking
5173

Overview

Sergei M. Gryaznov is affiliated with MAIA Biotechnology, Inc. in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these areas, their work focuses on several subfields including Molecular Biology, Immunology, Cancer Research, Oncology, and Physiology.

The scientist's research topics cover a range of biomedical investigations, notably in cancer mechanisms, RNA interference, advanced biosensing techniques, telomere biology, and immune responses. Specifically, their main topics of work include:

  • Cancer-related molecular mechanisms research
  • RNA Interference and Gene Delivery
  • Advanced biosensing and bioanalysis techniques
  • Telomeres, Telomerase, and Senescence
  • Immunotherapy and Immune Responses
  • Immune Response and Inflammation
  • Cancer Immunotherapy and Biomarkers

Sergei M. Gryaznov has contributed to several recent publications, illustrating ongoing research activity across these themes. Notable papers include:

  • "A MIR17HG-derived long noncoding RNA provides an essential chromatin scaffold for protein interaction and myeloma growth," published in 2022 in Blood
  • "Targeting TLR9 agonists to secondary lymphoid organs induces potent immune responses against HBV infection," published in 2022 in Molecular Therapy - Nucleic Acids
  • "Cancer Stem Cells and Anti-tumor Immunity," published in 2022 in Current Stem Cell Research & Therapy
  • "New Oligonucleotide 2'-O-Alkyl N3'→P5' (Thio)-Phosphoramidates as Potent Antisense Agents: Physicochemical Properties and Biological Activity," published in 2023 in Nucleic Acid Therapeutics
  • "A phase 2, multicenter, open-label, dose-optimization study evaluating telomere-targeting agent THIO sequenced with cemiplimab in patients with advanced NSCLC: Updated results," published in 2024 in Journal of Clinical Oncology

In terms of publication venues, Sergei M. Gryaznov has multiple articles featured in the following journals and conference abstracts:

  • Regular and Young Investigator Award Abstracts
  • Blood
  • Cancer Research
  • Journal of Clinical Oncology
  • Molecular Therapy - Nucleic Acids

Their collaborative network includes frequent co-authors such as Vlad Vitoc, İlgen Mender, Masood A. Shammas, Kenneth C. Anderson, and Nikhil C. Munshi, each contributing to multiple joint works. This reflects an engagement with researchers specializing in related biomedical and oncological fields.

Best Publications

  • Oligonucleotides having modified internucleoside linkages or terminal amino group

    Robert L. Letsinger;Sergei M. Gryaznov

  • Does a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence

    Ying Zou;Agnel Sfeir;Sergei M. Gryaznov;Jerry W. Shay

  • In vivo Inhibition of Lung Cancer by GRN163L: A Novel Human Telomerase Inhibitor

    Z. Gunnur Dikmen;Ginelle C. Gellert;Shalmica Jackson;Sergei Gryaznov

  • Lipid modification of GRN163, an N3′ → P5′ thio -phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition

    Brittney Shea Herbert;Brittney Shea Herbert;Ginelle C. Gellert;Amelia Hochreiter;Krisztina Pongracz

  • A Novel Telomerase Template Antagonist (GRN163) as a Potential Anticancer Agent

    Akira Asai;Yuko Oshima;Yoshihiro Yamamoto;Taka-aki Uochi

  • Oligonucleotide N3'→P5' phosphoramidates

    Sergei M. Gryaznov;Ronald G. Schultz;Jer-kang Chen

  • Oligodeoxyribonucleotide N3'.fwdarw.P5' Phosphoramidates: synthesis and Hybridization Properties

    Sergei Gryaznov;Jer-Kang Chen

  • Oligonucleotide N3′→N5′Phosphoramidate Duplexes

    Sergei M. Gryaznov;Ronald G. Schultz;Jer-kang Chen

  • Immunomodulatory spherical nucleic acids

    Aleksandar Filip Radovic-Moreno;Sergei Gryaznov

  • Accessibility of nuclear DNA to triplex-forming oligonucleotides: The integrated HIV-1 provirus as a target

    Carine Giovannangeli;Silvia Diviacco;Valérie Labrousse;Sergei Gryaznov

  • Synthesis of oligodeoxyribonucleotide N3'-->P5' phosphoramidates.

    Jer-Kang Chen;R. G. Schultz;D. H. Lloyd;S. M. Gryaznov

  • Oligonucleotide N3→P5' phosphoramidates: triplex DNA formation

    Sergei M. Gryaznov;Ronald G. Schultz;Jer-kang Chen

  • Telomerase Template Antagonist GRN163L Disrupts Telomere Maintenance, Tumor Growth, and Metastasis of Breast Cancer

    Amelia E. Hochreiter;Hongling Xiao;Erin M. Goldblatt;Sergei M. Gryaznov

  • Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma

    Meta W. Djojosubroto;Allison C. Chin;Ning Go;Sonja Schaetzlein

  • Oligonucleotide N3'-->P5' phosphoramidates as antisense agents.

    Sergei Gryaznov;Tomasz Skorski;Carla Cucco;Malgorzata Nieborowska-Skorska

  • New therapeutic approach for brain tumors: Intranasal delivery of telomerase inhibitor GRN163.

    Rintaro Hashizume;Tomoko Ozawa;Sergei M. Gryaznov;Andrew W. Bollen

  • Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer.

    Ginelle C. Gellert;Z. Gunnur Dikmen;Woodring E. Wright;Sergei Gryaznov

  • Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors.

    Brittney Shea-Herbert;Krisztina Pongracz;Jerry W. Shay;Sergei M. Gryaznov

  • Synthesis and properties of RNA analogs-oligoribonucleotide N3'-->P5' phosphoramidates

    Tracy J. Matray;Sergei M. Gryaznov

  • Oligonucleotide N3'-->P5' phosphoramidates as potential therapeutic agents.

    Sergei M Gryaznov

Frequent Co-Authors

Jerry W. Shay
Jerry W. Shay The University of Texas Southwestern Medical Center
Nikhil C. Munshi
Nikhil C. Munshi Harvard University
Robert L. Letsinger
Robert L. Letsinger Northwestern University
Woodring E. Wright
Woodring E. Wright The University of Texas Southwestern Medical Center
Calvin B. Harley
Calvin B. Harley Geron (United States)
Pierfrancesco Tassone
Pierfrancesco Tassone Magna Graecia University
David G. Beer
David G. Beer University of Michigan–Ann Arbor
Claude Hélène
Claude Hélène Grenoble Alpes University
Alexei Protopopov
Alexei Protopopov The University of Texas MD Anderson Cancer Center

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