His primary areas of study are Locked nucleic acid, Nucleic acid, Oligonucleotide, Stereochemistry and RNA. His research on Locked nucleic acid concerns the broader Biochemistry. His work deals with themes such as Nucleic acid structure, Polymerase, Gene, Angstrom and Combinatorial chemistry, which intersect with Nucleic acid.
DNA covers Jesper Wengel research in Oligonucleotide. Many of his research projects under Stereochemistry are closely connected to Monomer with Monomer, tying the diverse disciplines of science together. His study in RNA is interdisciplinary in nature, drawing from both Gene silencing and Computational biology.
Jesper Wengel focuses on Stereochemistry, Oligonucleotide, Nucleic acid, DNA and Locked nucleic acid. His Stereochemistry research incorporates themes from Thymine and Phosphoramidite. His study looks at the relationship between Oligonucleotide and topics such as RNA, which overlap with Complementary DNA.
Nucleic acid is the subject of his research, which falls under Biochemistry. Jesper Wengel has researched DNA in several fields, including Biophysics, Thermal stability and Pyrene. His Locked nucleic acid research is multidisciplinary, incorporating perspectives in Nucleic acid analogue and Nucleobase.
Jesper Wengel spends much of his time researching Oligonucleotide, Nucleic acid, DNA, Stereochemistry and Locked nucleic acid. His Oligonucleotide study integrates concerns from other disciplines, such as RNA, Molecular biology, Duplex and Nucleotide. Nucleic acid is a subfield of Biochemistry that he studies.
When carried out as part of a general Biochemistry research project, his work on Albumin, Nuclease and Serum albumin is frequently linked to work in Linker, therefore connecting diverse disciplines of study. His Stereochemistry research incorporates elements of Receptor, Base pair, Uracil and Oligonucleotide synthesis. Jesper Wengel has included themes like RNA splicing and Cell biology in his Locked nucleic acid study.
His main research concerns Oligonucleotide, DNA, Nucleic acid, Molecular biology and Biochemistry. His work on Locked nucleic acid as part of general Oligonucleotide research is frequently linked to Fluorescence in situ hybridization, bridging the gap between disciplines. The DNA study combines topics in areas such as Biophysics, Nucleotide and Aptamer.
His study in Nucleic acid is interdisciplinary in nature, drawing from both Active site, Structural motif, DNA polymerase II, RNA polymerase II and Transcription. His study in the field of Serum albumin, Albumin, Polymerase and Chemical biology also crosses realms of Linker. His Nucleic acid thermodynamics study incorporates themes from Quenching, Stereochemistry and Oligonucleotide synthesis.
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LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition
Alexei A. Koshkin;Sanjay K. Singh;Poul Nielsen;Vivek K. Rajwanshi.
Tetrahedron (1998)
Phytochemistry of the genus Piper
Virinder S. Parmar;Subhash C. Jain;Kirpal S. Bisht;Rajni Jain.
Phytochemistry (1997)
LNA (Locked Nucleic Acid): High-Affinity Targeting of Complementary RNA and DNA†
Birte Vester;Jesper Wengel.
Biochemistry (2004)
LNA: a versatile tool for therapeutics and genomics
Michael Petersen;Jesper Wengel.
Trends in Biotechnology (2003)
Potent and nontoxic antisense oligonucleotides containing locked nucleic acids
Claes R Wahlestedt;Peter Salmi;Liam Good;Johanna Kela.
Proceedings of the National Academy of Sciences of the United States of America (2000)
LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition
Sanjay K. Singh;Alexei A. Koshkin;Jesper Wengel;Poul Nielsen.
Chemical Communications (1998)
Synthetic genetic polymers capable of heredity and evolution
Vitor B. Pinheiro;Alexander I. Taylor;Christopher Cozens;Mikhail Abramov.
Science (2012)
Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)
Jesper Wengel.
Accounts of Chemical Research (1999)
LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes
Alexei Koshkin;Poul Nielsen;Michael Meldgaard;Vivek Kumar Rajwanshi.
Journal of the American Chemical Society (1998)
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
Jesper B. Bramsen;Maria B. Laursen;Anne F. Nielsen;Thomas B. Hansen.
Nucleic Acids Research (2009)
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