World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
91
Citations
25418
World Ranking
1051
National Ranking
568

Medicine

D-Index
91
Citations
25435
World Ranking
11902
National Ranking
6105

Overview

Gerald T. Nepom is affiliated with Virginia Mason Medical Center in the United States. Their research primarily focuses on medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology. Within these broad fields, Nepom's work frequently addresses subfields such as immunology, genetics, immunology and allergy, surgery, and endocrinology, diabetes, and metabolism.

Their research interests cover a range of topics related to immune function and disease, including diabetes and associated disorders, food allergy and anaphylaxis research, immune cell function and interaction, T-cell and B-cell immunology, diabetes management and research, pancreatic function and diabetes, and allergic rhinitis and sensitization.

Gerald T. Nepom has contributed extensively to scientific literature, with frequent publications appearing in several specialized venues. These include:

  • Journal of Allergy and Clinical Immunology
  • JCI Insight
  • Diabetes
  • Frontiers in Immunology
  • The Journal of Immunology

Their recent notable papers demonstrate a focus on immunological mechanisms and clinical outcomes related to diabetes and allergy, with examples such as:

  • "Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes" (2020, Nature Immunology)
  • "Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy" (2021, Journal of Allergy and Clinical Immunology)
  • "Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects" (2020, JCI Insight)
  • "Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: A randomized controlled trial" (2022, Journal of Allergy and Clinical Immunology)
  • "C-peptide and metabolic outcomes in trials of disease modifying therapy in new-onset type 1 diabetes: an individual participant meta-analysis" (2023, The Lancet Diabetes & Endocrinology)

Nepom has collaborated frequently with a group of co-authors, indicating ongoing partnerships in their research projects. Frequent co-authors include Carla J. Greenbaum, Srinath Sanda, Rasika A. Mathias, Kanika Kanchan, and Elisavet Serti.

Best Publications

  • MHC Class-II Molecules and Autoimmunity

    G T Nepom;H Erlich

  • Genetics of Type 1A Diabetes

    Patrick Concannon;Stephen S. Rich;Gerald T. Nepom

  • Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

    Christine Beeton;Heike Wulff;Nathan E. Standifer;Philippe Azam

  • Narcolepsy is strongly associated with the T-cell receptor alpha locus.

    Joachim Hallmayer;Juliette Faraco;Ling Lin;Stephanie Hesselson

  • MHC class II tetramers identify peptide-specific human CD4(+) T cells proliferating in response to influenza A antigen.

    Erik J. Novak;Andrew W. Liu;Gerald T. Nepom;William W. Kwok

  • HLA Genes associated with rheumatoid Arthritis. Identification of susceptibility alleles using specific oligonucleotide probes

    Gerald T. Nepom;Patricia Byers;Christine Seyfried;Louis A. Healey

  • Prediction and pathogenesis in type 1 diabetes.

    Anette G. Ziegler;Gerald T. Nepom

  • De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells.

    Mindi R. Walker;Bryan D. Carson;Gerald T. Nepom;Steven F. Ziegler

  • Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

    Yonghao Cao;Brittany A. Goods;Khadir Raddassi;Gerald T. Nepom

  • Systems Scale Interactive Exploration Reveals Quantitative and Qualitative Differences in Response to Influenza and Pneumococcal Vaccines

    Gerlinde Obermoser;Scott Presnell;Kelly Domico;Hui Xu

  • Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients

    Mark R. Rigby;Kristina M. Harris;Ashley Pinckney;Linda A. DiMeglio

  • Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells

    Francesco Vendrame;Antonello Pileggi;Elsa Laughlin;Gloria Allende

  • Identification of hla dw 14 genes in dr 4 positive rheumatoid arthritis

    G. T. Nepom;S. L. Holbeck;C. E. Seyfried;K. R. Wilske

  • Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing.

    Robert M. Hershberg;Paul E. Framson;Diane H. Cho;Lawrence Y. Lee

  • A unified hypothesis for the complex genetics of HLA associations with IDDM.

    Gerald T Nepom

  • Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind a Borrelia burgdorferi peptide

    Allen C. Steere;William Klitz;William Klitz;Elise E. Drouin;Ben A. Falk

  • Common variants in P2RY11 are associated with narcolepsy

    Birgitte R Kornum;Minae Kawashima;Minae Kawashima;Juliette Faraco;Ling Lin

  • The insulin A-chain epitope recognized by human T cells is posttranslationally modified.

    Stuart I. Mannering;Leonard C. Harrison;Nicholas A. Williamson;Jessica S. Morris

  • Molecular Basis for HLA-DQ Associations With IDDM

    Gerald T Nepom;William W Kwok

  • Successful Prospective Prediction of Type 1 Diabetes in Schoolchildren Through Multiple Defined Autoantibodies: An 8-year follow-up of the Washington State Diabetes Prediction Study

    James M. LaGasse;Michael S. Brantley;Nicola J. Leech;Rachel E. Rowe

Frequent Co-Authors

William W. Kwok
William W. Kwok University of Washington
Jane H. Buckner
Jane H. Buckner Virginia Mason Medical Center
Helena Reijonen
Helena Reijonen City Of Hope National Medical Center
Carla J. Greenbaum
Carla J. Greenbaum Virginia Mason Medical Center
Eric Mickelson
Eric Mickelson Fred Hutchinson Cancer Research Center
Åke Lernmark
Åke Lernmark Lund University
David M. Koelle
David M. Koelle University of Washington
Jerry P. Palmer
Jerry P. Palmer University of Washington
Eddie A. James
Eddie A. James Virginia Mason Medical Center
Karl Erik Hellström
Karl Erik Hellström University of Washington

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