His main research concerns Immunology, Type 1 diabetes, Autoimmunity, Islet and Antigen. His study focuses on the intersection of Immunology and fields such as Transplantation with connections in the field of Mannan-binding lectin. Diabetes mellitus covers Bart O. Roep research in Type 1 diabetes.
His work deals with themes such as Internal medicine, Insulin and Pathogenesis, which intersect with Diabetes mellitus. His work carried out in the field of Autoimmunity brings together such families of science as Cytotoxic T cell, Beta cell and Immunotherapy. His Antigen study combines topics in areas such as T cell, Autoantibody and Proinsulin.
His primary areas of investigation include Immunology, Type 1 diabetes, Autoimmunity, Islet and Immune system. In most of his Immunology studies, his work intersects topics such as Transplantation. His Type 1 diabetes research integrates issues from Internal medicine, Insulin and Disease.
His studies in Internal medicine integrate themes in fields like Gastroenterology and Oncology. Bart O. Roep has researched Autoimmunity in several fields, including Autoantibody, Beta cell, Pancreas and Immunotherapy. The Epitope study which covers Human leukocyte antigen that intersects with Allele and Genotype.
Bart O. Roep mainly investigates Type 1 diabetes, Diabetes mellitus, Immune system, Islet and Immunology. His Type 1 diabetes research includes themes of Bioinformatics, Intensive treatment, C-peptide and Autoimmunity, Disease. In his study, Disease progression is strongly linked to T cell, which falls under the umbrella field of Autoimmunity.
His research in Immune system intersects with topics in Antigen and Cell biology. His Islet research is multidisciplinary, incorporating elements of Transplantation and Genotype. Bart O. Roep connects Immunology with Context in his research.
Bart O. Roep mostly deals with Type 1 diabetes, Diabetes mellitus, Immune system, Disease and Autoimmunity. Type 1 diabetes is often connected to Bioinformatics in his work. Bart O. Roep focuses mostly in the field of Diabetes mellitus, narrowing it down to topics relating to Internal medicine and, in certain cases, Cell Plasticity and Cellular differentiation.
His studies deal with areas such as Carbohydrate metabolism, Antigen and Cell biology as well as Immune system. His work in Disease addresses issues such as Precision medicine, which are connected to fields such as Endotype, Genetic predisposition, Translational research and Islet. As a member of one scientific family, Bart O. Roep mostly works in the field of Immunotherapy, focusing on Peptide and, on occasion, Autoimmune disease.
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Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes
Shelley Lindley;Colin M. Dayan;Amanda Bishop;Bart O. Roep.
Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients
Francesco Dotta;Stefano Censini;Astrid G. S. van Halteren;Lorella Marselli.
Proceedings of the National Academy of Sciences of the United States of America (2007)
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
Ken T. Coppieters;Francesco Dotta;Natalie Amirian;Peter D. Campbell.
Journal of Experimental Medicine (2012)
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
Sefina Arif;Timothy I. Tree;Thomas P. Astill;Jennifer M. Tremble.
Journal of Clinical Investigation (2004)
The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure
Bart O. Roep.
Induction of Treg by monocyte‐derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD‐L1
Wendy W. J. Unger;Sandra Laban;Fleur S. Kleijwegt;Arno R. van der Slik.
European Journal of Immunology (2009)
CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
Ania Skowera;Richard J. Ellis;Ruben Varela-Calviño;Sefina Arif.
Journal of Clinical Investigation (2008)
Development of type 1 diabetes despite severe hereditary B-cell deficiency.
Stephan Martin;Dorothea Wolf-Eichbaum;Gaby Duinkerken;Werner A. Scherbaum.
The New England Journal of Medicine (2001)
Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes
Gabrielle G. M. Pinkse;Odette H. M. Tysma;Cees A. M. Bergen;Michel G. D. Kester.
Proceedings of the National Academy of Sciences of the United States of America (2005)
KIR in Type 1 Diabetes: Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects
Arno R. van der Slik;Bobby P.C. Koeleman;Willem Verduijn;G. Jan Bruining.
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