World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
95
Citations
28497
World Ranking
913
National Ranking
30

Medicine

D-Index
95
Citations
28498
World Ranking
10175
National Ranking
401

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Internal medicine

His main research concerns Immunology, Type 1 diabetes, Autoimmunity, Islet and Antigen. His study focuses on the intersection of Immunology and fields such as Transplantation with connections in the field of Mannan-binding lectin. Diabetes mellitus covers Bart O. Roep research in Type 1 diabetes.

His work deals with themes such as Internal medicine, Insulin and Pathogenesis, which intersect with Diabetes mellitus. His work carried out in the field of Autoimmunity brings together such families of science as Cytotoxic T cell, Beta cell and Immunotherapy. His Antigen study combines topics in areas such as T cell, Autoantibody and Proinsulin.

His most cited work include:

  • Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes (683 citations)
  • Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients (454 citations)
  • Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients (432 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of investigation include Immunology, Type 1 diabetes, Autoimmunity, Islet and Immune system. In most of his Immunology studies, his work intersects topics such as Transplantation. His Type 1 diabetes research integrates issues from Internal medicine, Insulin and Disease.

His studies in Internal medicine integrate themes in fields like Gastroenterology and Oncology. Bart O. Roep has researched Autoimmunity in several fields, including Autoantibody, Beta cell, Pancreas and Immunotherapy. The Epitope study which covers Human leukocyte antigen that intersects with Allele and Genotype.

He most often published in these fields:

  • Immunology (74.15%)
  • Type 1 diabetes (58.05%)
  • Autoimmunity (35.61%)

What were the highlights of his more recent work (between 2018-2021)?

  • Type 1 diabetes (58.05%)
  • Diabetes mellitus (27.32%)
  • Immune system (32.68%)

In recent papers he was focusing on the following fields of study:

Bart O. Roep mainly investigates Type 1 diabetes, Diabetes mellitus, Immune system, Islet and Immunology. His Type 1 diabetes research includes themes of Bioinformatics, Intensive treatment, C-peptide and Autoimmunity, Disease. In his study, Disease progression is strongly linked to T cell, which falls under the umbrella field of Autoimmunity.

His research in Immune system intersects with topics in Antigen and Cell biology. His Islet research is multidisciplinary, incorporating elements of Transplantation and Genotype. Bart O. Roep connects Immunology with Context in his research.

Between 2018 and 2021, his most popular works were:

  • Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. (89 citations)
  • Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. (89 citations)
  • Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes (51 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Internal medicine

Bart O. Roep mostly deals with Type 1 diabetes, Diabetes mellitus, Immune system, Disease and Autoimmunity. Type 1 diabetes is often connected to Bioinformatics in his work. Bart O. Roep focuses mostly in the field of Diabetes mellitus, narrowing it down to topics relating to Internal medicine and, in certain cases, Cell Plasticity and Cellular differentiation.

His studies deal with areas such as Carbohydrate metabolism, Antigen and Cell biology as well as Immune system. His work in Disease addresses issues such as Precision medicine, which are connected to fields such as Endotype, Genetic predisposition, Translational research and Islet. As a member of one scientific family, Bart O. Roep mostly works in the field of Immunotherapy, focusing on Peptide and, on occasion, Autoimmune disease.

Best Publications

  • Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

    Shelley Lindley;Colin M. Dayan;Amanda Bishop;Bart O. Roep

  • Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

    Ken T. Coppieters;Francesco Dotta;Natalie Amirian;Peter D. Campbell

  • Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients

    Francesco Dotta;Stefano Censini;Astrid G. S. van Halteren;Lorella Marselli

  • Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

    Sefina Arif;Timothy I. Tree;Thomas P. Astill;Jennifer M. Tremble

  • Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

    Bart O Roep;Bart O Roep;Sofia Thomaidou;René van Tienhoven;Arnaud Zaldumbide

  • The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure

    Bart O. Roep

  • Induction of Treg by monocyte‐derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD‐L1

    Wendy W. J. Unger;Sandra Laban;Fleur S. Kleijwegt;Arno R. van der Slik

  • CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

    Ania Skowera;Richard J. Ellis;Ruben Varela-Calviño;Sefina Arif

  • Expert consensus document: A consensus on the medical treatment of acromegaly

    Andrea Giustina;Philippe Chanson;David Kleinberg;Marcello D. Bronstein

  • Development of type 1 diabetes despite severe hereditary B-cell deficiency.

    Stephan Martin;Dorothea Wolf-Eichbaum;Gaby Duinkerken;Werner A. Scherbaum

  • Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes

    Gabrielle G. M. Pinkse;Odette H. M. Tysma;Cees A. M. Bergen;Michel G. D. Kester

  • Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

    Manuela Battaglia;Simi Ahmed;Mark S. Anderson;Mark A. Atkinson

  • Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes.

    T. P. Di Lorenzo;M. Peakman;B. O. Roep

  • KIR in Type 1 Diabetes: Disparate Distribution of Activating and Inhibitory Natural Killer Cell Receptors in Patients Versus HLA-Matched Control Subjects

    Arno R. van der Slik;Bobby P.C. Koeleman;Willem Verduijn;G. Jan Bruining

  • Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes

    Bart O Roep;Mark Atkinson;Matthias von Herrath

  • The vitamin D receptor gene FokI polymorphism: functional impact on the immune system.

    Evelyne van Etten;Lieve Verlinden;Annapaula Giulietti;Elizabeth Ramos-Lopez

  • Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial

    Pieter de Groot;Tanja Nikolic;Silvia Pellegrini;Valeria Sordi

  • Antigen Targets of Type 1 Diabetes Autoimmunity

    Bart O Roep;Mark Peakman

  • Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).

    Astrid G.S. van Halteren;Evelyne van Etten;Esther C. de Jong;Roger Bouillon

  • Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.

    Alexandra Zhernakova;Behrooz Z. Alizadeh;Behrooz Z. Alizadeh;Marianna Bevova;Miek A. van Leeuwen

  • Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review.

    Jeroen M K de Filette;Joeri J Pen;Lore Decoster;Thomas Vissers

  • Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.

    B. O. Roep;I. Stobbe;G. Duinkerken;J. J. Van Rood

Frequent Co-Authors

Mark Peakman
Mark Peakman King's College London
Bobby P.C. Koeleman
Bobby P.C. Koeleman Utrecht University
Jan W. Drijfhout
Jan W. Drijfhout Leiden University Medical Center
Daniel Pipeleers
Daniel Pipeleers Vrije Universiteit Brussel
Behrooz Z. Alizadeh
Behrooz Z. Alizadeh University Medical Center Groningen
Timothy I. M. Tree
Timothy I. M. Tree King's College London
Peter A. van Veelen
Peter A. van Veelen Leiden University Medical Center
Frans H.J. Claas
Frans H.J. Claas Leiden University Medical Center
Hubert Kolb
Hubert Kolb Heinrich Heine University Düsseldorf

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