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Immunology

D-Index
42
Citations
8169
World Ranking
4883
National Ranking
407

Overview

Timothy I. M. Tree is affiliated with King's College London in the United Kingdom. Their research spans multiple areas within medicine and biomedical science, with a significant emphasis on immunology, genetics, and molecular biology.

The scientist has contributed to research in several main fields of study, including:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these broader fields, key subfields that characterize their work include:

  • Immunology
  • Genetics
  • Surgery
  • Infectious Diseases
  • Endocrinology, Diabetes and Metabolism

The main research topics covered by their publications reflect a focus on both immune system function and metabolic disorders. These topics include:

  • Diabetes and associated disorders
  • Pancreatic function and diabetes
  • Immune Cell Function and Interaction
  • Diabetes Management and Research
  • T-cell and B-cell Immunology
  • SARS-CoV-2 and COVID-19 Research
  • Immunotherapy and Immune Responses

Timothy I. M. Tree has published research in various scientific venues, with a number of papers appearing particularly frequently in the following journals:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Immunology
  • Clinical & Experimental Immunology
  • Journal of Hepatology
  • The Lancet

Some of the recent publications by Tree include:

  • Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study, 2021, The Lancet Oncology
  • The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study, 2021, The Lancet Rheumatology
  • The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate, 2021, Nature Immunology
  • IL-2-based approaches to Treg enhancement, 2022, Clinical & Experimental Immunology
  • Repeated 5-day cycles of low dose aldesleukin in amyotrophic lateral sclerosis (IMODALS): A phase 2a randomised, double-blind, placebo-controlled trial, 2020, EBioMedicine

Tree frequently collaborates with other researchers, with several co-authors appearing in numerous publications. Regular collaborators include:

  • Clara Domingo-Vila
  • Mark Peakman
  • Emily Pollock
  • Jennie H. M. Yang
  • Katie J. Doores

Best Publications

  • Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

    Shelley Lindley;Colin M. Dayan;Amanda Bishop;Bart O. Roep

  • Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

    Andrea Cossarizza;Hyun Dong Chang;Andreas Radbruch;Andreas Acs

  • Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

    Sefina Arif;Timothy I. Tree;Thomas P. Astill;Jennifer M. Tremble

  • Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a prospective observational study.

    Leticia Monin;Adam G Laing;Miguel Muñoz-Ruiz;Duncan R McKenzie

  • CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

    Ania Skowera;Richard J. Ellis;Ruben Varela-Calviño;Sefina Arif

  • Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death

    Sefina Arif;Fabrice Moore;Katherine Marks;Thomas Bouckenooghe

  • Type 1 Diabetes-Associated IL2RA Variation Lowers IL-2 Signaling and Contributes to Diminished CD4+CD25+ Regulatory T Cell Function

    Garima Garg;Jennifer R Tyler;Jennie H M Yang;Antony J Cutler

  • Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

    J. M. Lawson;J. Tremble;Colin Mark Dayan;H. Beyan

  • Regulatory T cell dysfunction in type 1 diabetes: what’s broken and how can we fix it?

    Caroline M. Hull;Mark Peakman;Mark Peakman;Timothy I. M. Tree;Timothy I. M. Tree

  • Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

    Mohammad Alhadj Ali;Yuk-Fun Liu;Yuk-Fun Liu;Sefina Arif;Danijela Tatovic

  • Systemic inflammatory response and neuromuscular involvement in amyotrophic lateral sclerosis

    Ching-Hua Lu;Kezia Allen;Felicia Oei;Emanuela Leoni

  • The effect of methotrexate and targeted immunosuppression on humoral and cellular immune responses to the COVID-19 vaccine BNT162b2: a cohort study.

    Satveer K Mahil;Katie Bechman;Antony Raharja;Clara Domingo-Vila

  • Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.

    John A. Todd;Marina Evangelou;Antony J. Cutler;Marcin L. Pekalski

  • Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry

    Gavin M Mason;Katie Lowe;Rossella Melchiotti;Richard Ellis

  • Immune modulation in humans: implications for type 1 diabetes mellitus

    Bart O. Roep;Timothy I. M. Tree

  • CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL‐17 in a STAT3‐dependent manner

    Behdad Afzali;Peter J. Mitchell;Francis C. Edozie;Giovanni A.M. Povoleri

  • Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture.

    Jennifer S. Allen;Karl Pang;Ania Skowera;Richard Ellis

  • IL-2 therapy restores regulatory T-cell dysfunction induced by calcineurin inhibitors.

    Gavin Whitehouse;Gavin Whitehouse;Elizabeth Gray;Elizabeth Gray;Sotiris Mastoridis;Sotiris Mastoridis;Elliot Merritt;Elliot Merritt

  • Generation of human islet-specific regulatory T cells by TCR gene transfer

    Caroline M. Hull;Caroline M. Hull;Lauren E. Nickolay;Lauren E. Nickolay;Megan Estorninho;Megan Estorninho;Max W. Richardson

  • Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

    Timothy I.M. Tree;Jennifer Lawson;Hannah Edwards;Ania Skowera

  • IL-2-based approaches to Treg enhancement

    Unknown

Frequent Co-Authors

Mark Peakman
Mark Peakman King's College London
Bart O. Roep
Bart O. Roep Leiden University Medical Center
Adrian Hayday
Adrian Hayday King's College London
Katie J. Doores
Katie J. Doores King's College London
Michael H. Malim
Michael H. Malim King's College London
John A. Todd
John A. Todd University of Oxford
Linda S. Wicker
Linda S. Wicker University of Oxford
Ammar Al-Chalabi
Ammar Al-Chalabi King's College London
Deborah J. Smyth
Deborah J. Smyth University of Cambridge
Robert Deans
Robert Deans Osiris Therapeutics (United States)

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