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Immunology

D-Index
81
Citations
19159
World Ranking
1589
National Ranking
135

Medicine

D-Index
81
Citations
19187
World Ranking
16816
National Ranking
1529

Overview

Mark Peakman is affiliated with King's College London in the United Kingdom. Their research centers primarily on medicine, with significant contributions to biochemistry, genetics, molecular biology, immunology, and microbiology. Key subfields in their work include genetics, immunology, endocrinology, diabetes and metabolism, surgery, and physiology.

The scientist has published extensively on topics related to diabetes and associated disorders, with particular emphasis on pancreatic function and diabetes, diabetes management and research, immune cell function and interaction, T-cell and B-cell immunology, immunotherapy and immune responses, as well as asthma and respiratory diseases.

Peakman's work appears frequently in several academic journals. Venues with multiple publications include:

  • Diabetologia
  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Diabetes/Metabolism Research and Reviews
  • EBioMedicine

Among their recent research papers are:

  • Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes, 2020, Nature Immunology
  • Multiplex T Cell Stimulation Assay Utilizing a T Cell Activation Reporter-Based Detection System, 2020, Frontiers in Immunology
  • INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes, 2022, Trials
  • Synchronization of the Normal Human Peripheral Immune System: A Comprehensive Circadian Systems Immunology Analysis, 2020, Scientific Reports
  • GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells, 2020, Diabetologia

In collaborative research, Peakman frequently coauthors with several other scientists, including:

  • Timothy Tree
  • Mikael Knip
  • Chantal Mathieu
  • Lut Overbergh
  • Anke M. Schulte

Best Publications

  • Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

    Shelley Lindley;Colin M. Dayan;Amanda Bishop;Bart O. Roep

  • Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health

    Sefina Arif;Timothy I. Tree;Thomas P. Astill;Jennifer M. Tremble

  • A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides

    Linda Wooldridge;Julia Ekeruche-Makinde;Hugo A. van den Berg;Anna Skowera;Anna Skowera

  • CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

    Ania Skowera;Richard J. Ellis;Ruben Varela-Calviño;Sefina Arif

  • Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.

    Manuela Battaglia;Simi Ahmed;Mark S. Anderson;Mark A. Atkinson

  • Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

    Chung-Ching Chu;Niwa Ali;Panagiotis Karagiannis;Paola Di Meglio

  • Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes.

    T. P. Di Lorenzo;M. Peakman;B. O. Roep

  • Elevated serum levels of macrophage-derived cytokines precede and accompany the onset of IDDM

    M. J. Hussain;M. Peakman;H. Gallati;S. S. S. Lo

  • Antigen Targets of Type 1 Diabetes Autoimmunity

    Bart O Roep;Mark Peakman

  • Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated β-Cell Death

    Sefina Arif;Fabrice Moore;Katherine Marks;Thomas Bouckenooghe

  • Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

    Sefina Arif;Pia Leete;Vy Thuy Nguyen;Katherine Marks

  • Type 1 Diabetes-Associated IL2RA Variation Lowers IL-2 Signaling and Contributes to Diminished CD4+CD25+ Regulatory T Cell Function

    Garima Garg;Jennifer R Tyler;Jennie H M Yang;Antony J Cutler

  • Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.

    Anna Marta Bulek;David Cole;Ania Skowera;Ania Skowera;Garry Michael Dolton

  • Simultaneous Detection of Circulating Autoreactive CD8 + T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers

    Jurjen H. Velthuis;Wendy W. Unger;Joana R.F. Abreu;Gaby Duinkerken;Gaby Duinkerken

  • Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes

    J. M. Lawson;J. Tremble;Colin Mark Dayan;H. Beyan

  • Regulatory T cell dysfunction in type 1 diabetes: what’s broken and how can we fix it?

    Caroline M. Hull;Mark Peakman;Mark Peakman;Timothy I. M. Tree;Timothy I. M. Tree

  • Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes

    Federica Vecchio;Nicola Lo Buono;Angela Stabilini;Laura Nigi

  • Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes

    Mohammad Alhadj Ali;Yuk-Fun Liu;Yuk-Fun Liu;Sefina Arif;Danijela Tatovic

  • Costimulation Modulation With Abatacept in Patients With Recent-Onset Type 1 Diabetes: Follow-up 1 Year After Cessation of Treatment

    Tihamer Orban;Brian Bundy;Dorothy J. Becker;Linda A. DiMeglio

  • Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

    Menno van Lummel;Gaby Duinkerken;Peter A. van Veelen;Arnoud de Ru

  • Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

    David Cole;Anna Marta Bulek;Garry Michael Dolton;Andrea J. Schauenberg

  • Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1

    Sefina Arif;Pia Leete;Vy Nguyen;Katherine Marks

Frequent Co-Authors

Diego Vergani
Diego Vergani King's College London
Bart O. Roep
Bart O. Roep Leiden University Medical Center
Timothy I. M. Tree
Timothy I. M. Tree King's College London
Andrew K. Sewell
Andrew K. Sewell Cardiff University
John J. Miles
John J. Miles James Cook University
Adrian Hayday
Adrian Hayday King's College London
David Price
David Price University of Aberdeen
David B. Dunger
David B. Dunger University of Cambridge
John A. Todd
John A. Todd University of Oxford
Simon Wessely
Simon Wessely King's College London

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