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Medicine

D-Index
103
Citations
34005
World Ranking
7434
National Ranking
83

Overview

Daniel Pipeleers is affiliated with Vrije Universiteit Brussel in Belgium and has contributed extensively to the fields of medicine, biochemistry, genetics, and molecular biology. Their research primarily focuses on pancreatic function and diabetes, with significant work in endocrinology, diabetes management, and metabolism.

The scientist's recent papers cover various aspects of diabetes treatment and pancreatic cell function. Notable publications include:

  • Encapsulated stem cell-derived β cells exert glucose control in patients with type 1 diabetes, 2023, Nature Biotechnology
  • Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry, 2023, The Lancet Diabetes & Endocrinology
  • 196-LB: Stem Cell-Derived Islet Replacement Therapy (VC-02) Demonstrates Production of C-Peptide in Patients with Type 1 Diabetes (T1D) and Hypoglycemia Unawareness, 2021, Diabetes
  • Function and composition of pancreatic islet cell implants in omentum of type 1 diabetes patients, 2021, American Journal of Transplantation
  • Lower beta cell yield from donor pancreases after controlled circulatory death prevented by shortening acirculatory warm ischemia time and by using IGL-1 cold preservation solution, 2021, PLoS ONE

Their work appears frequently in journals including:

  • American Journal of Transplantation
  • Cell Transplantation
  • Transplantation
  • Nature Biotechnology
  • The Lancet Diabetes & Endocrinology

Frequent co-authors in Pipeleers' research include:

  • Bart Keymeulen
  • Daniel Jacobs-Tulleneers-Thevissen
  • Zhidong Ling
  • Pieter Gillard
  • Diedert Luc De Paep

Research topics covered by Pipeleers and their collaborators encompass:

  • Pancreatic function and diabetes
  • Diabetes Management and Research
  • Diabetes and associated disorders
  • Cannabis and Cannabinoid Research
  • MicroRNA in disease regulation
  • Renal Transplantation Outcomes and Treatments
  • Diabetes Treatment and Management

Their subfields of study reflect a multidisciplinary approach, including surgery, endocrinology, diabetes and metabolism, genetics, pharmacology, and cancer research. The scientist's work contributes to both clinical and molecular understanding of diabetes, graft function, and islet transplantation outcomes.

Best Publications

  • Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.

    Bart Keymeulen;Evy Vandemeulebroucke;Anette G. Ziegler;Chantal Mathieu

  • Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

    Kiavash Movahedi;Damya Laoui;Conny Gysemans;Martijn Baeten

  • Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas.

    Xiaobo Xu;Joke D'Hoker;Joke D'Hoker;Geert Stange;Geert Stange;Stefan Bonné;Stefan Bonné

  • Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation.

    Miriam Cnop;Jean Claude Hannaert;Anne Hoorens;Décio L. Eizirik

  • GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress

    Bernardo Yusta;Laurie L. Baggio;Jennifer L. Estall;Jackie A. Koehler

  • Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

    Anick De Vos;Henry Heimberg;Erik Quartier;Peter Huypens

  • Interplay of nutrients and hormones in the regulation of insulin release.

    D. G. Pipeleers;F. C. Schuit;C. F. H. Van Schravendijk;M. Van De Winkel

  • miR-375 Targets 3′-Phosphoinositide–Dependent Protein Kinase-1 and Regulates Glucose-Induced Biological Responses in Pancreatic β-Cells

    Abdelfattah El Ouaamari;Nadine Baroukh;Geert A. Martens;Patricia Lebrun

  • Glucose Sensing in Pancreatic β-Cells: A Model for the Study of Other Glucose-Regulated Cells in Gut, Pancreas, and Hypothalamus

    Franciscus Schuit;Peter Huypens;Henry Heimberg;Daniel Pipeleers

  • Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells.

    F Schuit;A De Vos;S Farfari;K Moens

  • Cytokines Induce Deoxyribonucleic Acid Strand Breaks and Apoptosis in Human Pancreatic Islet Cells

    Carol A. Delaney;Dejan Pavlovic;Anne Hoorens;Daniel G. Pipeleers

  • Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program.

    A Hoorens;M Van de Casteele;G Klöppel;D Pipeleers

  • Cytokines suppress human islet function irrespective of their effects on nitric oxide generation.

    Décio L. Eizirik;Stellan Sandler;Nils Welsh;Marina Cetkovic-Cvrlje

  • Determinants of the selective toxicity of alloxan to the pancreatic B cell.

    Willy J. Malaisse;Francine Malaisse-Lagae;Abdullah Sener;Daniel G. Pipeleers

  • A new in vitro model for the study of pancreatic A and B cells.

    D G Pipeleers;P A in't Veld;M Van de Winkel;E Maes

  • Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells

    Frans Schuit;P A In't Veld;D G Pipeleers

  • Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass.

    B Keymeulen;M Walter;Chantal Mathieu;L Kaufman

  • Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury.

    Decio L. Eizirik;Daniel G. Pipeleers;Zhidong Ling;Nils Welsh

  • Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes

    Gabrielle G. M. Pinkse;Odette H. M. Tysma;Cees A. M. Bergen;Michel G. D. Kester

  • Interleukin-6 regulates pancreatic alpha-cell mass expansion.

    Helga Ellingsgaard;Jan A Ehses;Eva B Hammar;Leentje Van Lommel

Frequent Co-Authors

Frans Schuit
Frans Schuit KU Leuven
Harry Heimberg
Harry Heimberg Vrije Universiteit Brussel
Willy Malaisse
Willy Malaisse Université Libre de Bruxelles
Bart O. Roep
Bart O. Roep Leiden University Medical Center
Decio L. Eizirik
Decio L. Eizirik Université Libre de Bruxelles
Luc Bouwens
Luc Bouwens Vrije Universiteit Brussel
Claes Hellerström
Claes Hellerström Uppsala University
Åke Lernmark
Åke Lernmark Lund University

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