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Overview

Frans H.J. Claas was affiliated with Leiden University Medical Center in the Netherlands. Their research primarily focused on the fields of Medicine and Immunology and Microbiology, with extensive work in Immunology, Transplantation, Surgery, Epidemiology, and Public Health, Environmental and Occupational Health.

Claas contributed significantly to topics related to renal transplantation outcomes and treatments, T-cell and B-cell immunology, immune cell function and interaction, organ transplantation techniques and outcomes, reproductive system and pregnancy, renal diseases and glomerulopathies, and cytomegalovirus and herpesvirus research.

Their research output included publications in frequent venues such as:

  • HLA
  • Frontiers in Immunology
  • Transplant International
  • Journal of Reproductive Immunology
  • Kidney International

Frans H.J. Claas co-authored with multiple researchers, including:

  • Sebastiaan Heidt
  • Geert W. Haasnoot
  • Michael Eikmans
  • Dave L. Roelen
  • Arend Mulder

Some notable recent papers associated with Claas' research include:

  • Eplet Mismatch Load and De Novo Occurrence of Donor-Specific Anti-HLA Antibodies, Rejection, and Graft Failure after Kidney Transplantation: An Observational Cohort Study (2020), Journal of the American Society of Nephrology
  • The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses (2020), Immunity
  • HLA-EMMA: A user-friendly tool to analyse HLA class I and class II compatibility on the amino acid level (2020), HLA
  • Significance of HLA-DQ in kidney transplantation: time to reevaluate human leukocyte antigen-matching priorities to improve transplant outcomes? An expert review and recommendations (2021), Kidney International
  • Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance (2021), Frontiers in Immunology

Best Publications

  • Isolation of Mesenchymal Stem Cells of Fetal or Maternal Origin from Human Placenta

    Pieternella S. in 't Anker;Sicco A. Scherjon;Carin Kleijburg‐van der Keur;Godelieve M.J.S. de Groot‐Swings

  • Amniotic fluid as a novel source of mesenchymal stem cells for therapeutic transplantation

    Pieternella S. in `t Anker;Sicco A. Scherjon;Carin Kleijburg-van der Keur;Willy A. Noort

  • Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

    Rizwan Romee;Maximillian Rosario;Melissa M. Berrien-Elliott;Julia A. Wagner

  • Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation.

    Brian D. Tait;Caner Süsal;Howard M. Gebel;Peter W. Nickerson

  • Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

    Susan E. Hiby;Richard Apps;Andrew M. Sharkey;Lydia E. Farrell

  • Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy.

    Tamara Tilburgs;Dave L. Roelen;Barbara J. van der Mast;Godelieve M. de Groot-Swings

  • The Effect of Tolerance to Noninherited Maternal HLA Antigens on the Survival of Renal Transplants from Sibling Donors

    W.J. Burlingham;A.P. Grailer;D.M. Heisey;F.H.J. Claas

  • Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling

    Jon J. Van Rood;Fausto R. Loberiza;Mei Jie Zhang;Machteld Oudshoorn

  • Allo-HLA reactivity of virus-specific memory T cells is common.

    Avital L. Amir;Lloyd J. A. D'Orsogna;Dave L. Roelen;Marleen M. van Loenen

  • Autologous Bone Marrow-Derived Mesenchymal Stromal Cells for the Treatment of Allograft Rejection After Renal Transplantation: Results of a Phase I Study

    Marlies E.J. Reinders;Johan W. de Fijter;Helene Roelofs;Ingeborg M. Bajema

  • European Renal Best Practice Guideline on kidney donor and recipient evaluation and perioperative care

    Daniel Abramowicz;Pierre Cochat;Frans H. J. Claas;Uwe Heemann

  • Composition of Human Skin Microbiota Affects Attractiveness to Malaria Mosquitoes

    Niels O. Verhulst;Yu Tong Qiu;Hans Beijleveld;Chris Maliepaard

  • Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life.

    F. H. J. Claas;Y. Gijbels;J. Van Der Velden-De Munck;J. J. Van Rood

  • Differential Distribution of CD4+CD25bright and CD8+CD28− T-cells in Decidua and Maternal Blood During Human Pregnancy

    T. Tilburgs;D.L. Roelen;B.J. van der Mast;J.J. van Schip

  • Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients

    Carlos Benítez;María-Carlota Londoño;Rosa Miquel;Tommaso-Maria Manzia

  • Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.

    Anat R. Tambur;Patricia Campbell;Frans H. Claas;Sandy Feng

  • Effect of One-HLA-DR-Antigen–Matched and Completely HLA-DR–Mismatched Blood Transfusions on Survival of Heart and Kidney Allografts

    E L Lagaaij;I P Hennemann;M Ruigrok;M W de Haan

  • Increased Immunogenicity and Cause of Graft Loss of Old Donor Kidneys

    Johan W. De Fijter;Marko J. K. Mallat;Ilias I. N. Doxiadis;Jan Ringers

  • The acceptable mismatch program as a fast tool for highly sensitized patients awaiting a cadaveric kidney transplantation: short waiting time and excellent graft outcome.

    Frans H. J. Claas;Marian D. Witvliet;René J. Duquesnoy;Guido G. Persijn

  • The Dutch national living donor kidney exchange program.

    Marry De Klerk;Karin M. Keizer;Frans H. J. Claas;Marian Witvliet

  • Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells.

    Tamara Tilburgs;Sicco A. Scherjon;Barbara J. van der Mast;Geert W. Haasnoot

Frequent Co-Authors

Dave L. Roelen
Dave L. Roelen Leiden University Medical Center
Arend Mulder
Arend Mulder Leiden University Medical Center
Ilias I.N. Doxiadis
Ilias I.N. Doxiadis Leiden University Medical Center
Willem Weimar
Willem Weimar Erasmus University Rotterdam
Anneke Brand
Anneke Brand Leiden University Medical Center
Cees van Kooten
Cees van Kooten Leiden University Medical Center
Machteld Oudshoorn
Machteld Oudshoorn Leiden University
Rene J. Duquesnoy
Rene J. Duquesnoy University of Pittsburgh
Carla C. Baan
Carla C. Baan Erasmus University Rotterdam
Irma Joosten
Irma Joosten Radboud University

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