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Immunology

D-Index
56
Citations
10227
World Ranking
3744
National Ranking
141

Overview

Dave L. Roelen is affiliated with Leiden University Medical Center in the Netherlands. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on transplantation and immune response mechanisms.

The scientist has contributed to several subfields including Transplantation, Immunology, Surgery, Nephrology, and Obstetrics and Gynecology. Their work often concentrates on renal transplantation outcomes and treatments, T-cell and B-cell immunology, renal diseases and glomerulopathies, reproductive system and pregnancy, pregnancy and preeclampsia studies, the complement system in diseases, and pregnancy and medication impact.

Recent publications authored or co-authored by Dave L. Roelen include:

  • HLA-EMMA: A user-friendly tool to analyse HLA class I and class II compatibility on the amino acid level, 2020, HLA
  • Human leukocyte antigen selected allogeneic mesenchymal stromal cell therapy in renal transplantation: The Neptune study, a phase I single-center study, 2020, American Journal of Transplantation
  • Autologous bone marrow-derived mesenchymal stromal cell therapy with early tacrolimus withdrawal: The randomized prospective, single-center, open-label TRITON study, 2021, American Journal of Transplantation
  • Generation and reactivity analysis of human recombinant monoclonal antibodies directed against epitopes on HLA-DR, 2020, American Journal of Transplantation
  • Causes of Kidney Graft Failure in a Cohort of Recipients With a Very Long-Time Follow-Up After Transplantation, 2022, Frontiers in Medicine

Frequent co-authors who have collaborated with Roelen include:

  • Sebastiaan Heidt
  • Frans H.J. Claas
  • Michael Eikmans
  • Michiel G.H. Betjes
  • Marlies E. J. Reinders

Their publications have appeared in various scholarly journals, with notable numbers in:

  • HLA
  • Frontiers in Immunology
  • Transplantation
  • American Journal of Transplantation
  • Transplant International

Best Publications

  • Evidence for a selective migration of fetus-specific CD4+CD25bright regulatory T cells from the peripheral blood to the decidua in human pregnancy.

    Tamara Tilburgs;Dave L. Roelen;Barbara J. van der Mast;Godelieve M. de Groot-Swings

  • Allo-HLA reactivity of virus-specific memory T cells is common.

    Avital L. Amir;Lloyd J. A. D'Orsogna;Dave L. Roelen;Marleen M. van Loenen

  • Autologous Bone Marrow-Derived Mesenchymal Stromal Cells for the Treatment of Allograft Rejection After Renal Transplantation: Results of a Phase I Study

    Marlies E.J. Reinders;Johan W. de Fijter;Helene Roelofs;Ingeborg M. Bajema

  • Differential Distribution of CD4+CD25bright and CD8+CD28− T-cells in Decidua and Maternal Blood During Human Pregnancy

    T. Tilburgs;D.L. Roelen;B.J. van der Mast;J.J. van Schip

  • Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients

    Carlos Benítez;María-Carlota Londoño;Rosa Miquel;Tommaso-Maria Manzia

  • Fetal-maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells.

    Tamara Tilburgs;Sicco A. Scherjon;Barbara J. van der Mast;Geert W. Haasnoot

  • Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation

    Volkert A. L. Huurman;Volkert A. L. Huurman;Robert Hilbrands;Gabriëlle G. M. Pinkse;Gabriëlle G. M. Pinkse;Pieter Gillard;Pieter Gillard

  • Human Decidual Tissue Contains Differentiated CD8(+) Effector-Memory T Cells with Unique Properties

    Tamara Tilburgs;Dorrith Schonkeren;Michael Eikmans;Nicole M. Nagtzaam

  • The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched human leukocyte antigens.

    Marlies K. A. Dankers;Marian D. Witvliet;Dave L. Roelen;Peter De Lange

  • Calcineurin inhibitors affect B cell antibody responses indirectly by interfering with T cell help

    S Heidt;D L Roelen;C Eijsink;M Eikmans

  • Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin.

    Sebastiaan Heidt;Dave L. Roelen;Chantal Eijsink;Cees van Kooten

  • Anti‐LGI1 encephalitis is strongly associated with HLA‐DR7 and HLA‐DRB4

    Agnes van Sonderen;Dave L. Roelen;Johannes A. Stoop;Robert M. Verdijk

  • Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm

    Jan H. N. Lindeman;Hazem Abdul-Hussien;Alexander F. M. Schaapherder;J. Hajo Van Bockel

  • Follicular T helper cells and humoral reactivity in kidney transplant patients.

    G. N. de Graav;M. Dieterich;D. A. Hesselink;K. Boer

  • A cell-based approach to the minimization of immunosuppression in renal transplantation.

    James A Hutchinson;Beate G Brem-Exner;Paloma Riquelme;Dave Roelen

  • Pregnancy can induce long-persisting primed CTLs specific for inherited paternal HLA antigens.

    Corine A van Kampen;Minke F.J Versteeg-van der Voort Maarschalk;Janneke Langerak-Langerak;Els van Beelen

  • Long-term Evaluation of Allogeneic Bone Marrow-derived Mesenchymal Stromal Cell Therapy for Crohn's Disease Perianal Fistulas.

    Marieke C Barnhoorn;Martin N J M Wasser;Helene Roelofs;P W Jeroen Maljaars

  • Comparison of decidual leukocytes following spontaneous vaginal delivery and elective cesarean section in uncomplicated human term pregnancy

    Aliana P Sindram-Trujillo;Sicco A Scherjon;Paula P.van Hulst-van Miert;Humphrey H.H Kanhai

  • Differential immunomodulatory effects of fetal versus maternal multipotent stromal cells

    Dave L. Roelen;Barbara J. van der Mast;Pieternella S. in't Anker;Carin Kleijburg

  • Prolongation of skin graft survival by modulation of the alloimmune response with alternatively activated dendritic cells.

    Roelen Dl;Schuurhuis Dh;van den Boogaardt De;Koekkoek K

  • Allo-HLA reactivity of virus-specific memory T cells is common. Blood. 2010;115(15):3146-3157

    A. L. Amir;L. J. D'orsogna;D. L. Roelen

Frequent Co-Authors

Frans H.J. Claas
Frans H.J. Claas Leiden University Medical Center
Ilias I.N. Doxiadis
Ilias I.N. Doxiadis Leiden University Medical Center
Arend Mulder
Arend Mulder Leiden University Medical Center
Cees van Kooten
Cees van Kooten Leiden University Medical Center
Anneke Brand
Anneke Brand Leiden University Medical Center
Carla C. Baan
Carla C. Baan Erasmus University Rotterdam
Machteld Oudshoorn
Machteld Oudshoorn Leiden University
Irma Joosten
Irma Joosten Radboud University
Ineke J. M. ten Berge
Ineke J. M. ten Berge University of Amsterdam
Michiel L. Bots
Michiel L. Bots Utrecht University

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