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Immunology

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57
Citations
9827
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3645
National Ranking
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Overview

Arend Mulder is affiliated with Leiden University Medical Center in the Netherlands. Their research spans the fields of immunology and microbiology as well as medicine, with a focus on immunology, oncology, hematology, transplantation, and surgery as subfields of study.

The main topics covered in their work include:

  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Renal Transplantation Outcomes and Treatments
  • Transplantation: Methods and Outcomes
  • Chemokine receptors and signaling

Mulder's recent publications illustrate a range of research interests and contributions:

  • "The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses," 2020, Immunity
  • "Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance," 2021, Frontiers in Immunology
  • "Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responses," 2021, Scientific Reports
  • "A Comprehensive Evaluation of the Antibody-Verified Status of Eplets Listed in the HLA Epitope Registry," 2022, Frontiers in Immunology
  • "Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S," 2022, Journal for ImmunoTherapy of Cancer

The research outputs are frequently published in venues such as:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Immunity
  • HLA
  • Annals of the Rheumatic Diseases

Mulder collaborates often with several researchers, with frequent co-authors including:

  • Frans H.J. Claas
  • Sebastiaan Heidt
  • Marlieke L.M. Jongsma
  • Antonius A. de Waard
  • Tamara Verkerk

These collaborations reflect integrated efforts in immunological research, particularly within transplantation immunology and antigen receptor engineering. The work often addresses mechanisms of immune tolerance, cellular interactions shaped by HLA molecules, and immune responses relevant to transplantation and cancer immunotherapy.

Best Publications

  • Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia

    Rizwan Romee;Maximillian Rosario;Melissa M. Berrien-Elliott;Julia A. Wagner

  • Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

    Susan E. Hiby;Richard Apps;Andrew M. Sharkey;Lydia E. Farrell

  • MANNOSE RECEPTOR-MEDIATED UPTAKE OF ANTIGENS STRONGLY ENHANCES HLA CLASS II-RESTRICTED ANTIGEN PRESENTATION BY CULTURED DENDRITIC CELLS

    M. C. A. A. Tan;A. M. Mommaas;J. W. Drijfhout;R. Jordens

  • Bortezomib down-regulates the cell surface expression of HLA-class I and enhances natural killer cell-mediated lysis of myeloma

    Jumei Shi;Guido J. Tricot;Tarun K. Garg;Priyangi A. Malaviarachchi

  • Peptide antagonism as a mechanism for NK cell activation.

    Lena Fadda;Gwenoline Borhis;Parvin Ahmed;Kuldeep Cheent

  • Calcineurin inhibitors affect B cell antibody responses indirectly by interfering with T cell help

    S Heidt;D L Roelen;C Eijsink;M Eikmans

  • Effects of immunosuppressive drugs on purified human B cells: evidence supporting the use of MMF and rapamycin.

    Sebastiaan Heidt;Dave L. Roelen;Chantal Eijsink;Cees van Kooten

  • Down-regulation of HLA-A and HLA-Bw6, but not HLA-Bw4, allospecificities in leukemic cells: an escape mechanism from CTL and NK attack?

    Christian Demanet;Arend Mulder;Veronique Deneys;Maria J. Worsham

  • The Impact of Amino Acid Variability on Alloreactivity Defines a Functional Distance Predictive of Permissive HLA-DPB1 Mismatches in Hematopoietic Stem Cell Transplantation

    Pietro Crivello;Laura Zito;Federico Sizzano;Elisabetta Zino

  • Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

    Jan H Kessler;Selina Khan;Ulrike Seifert;Sylvie Le Gall

  • Induction of MHC-class I restricted human suppressor T cells by peptide priming in vitro.

    Shuiping Jiang;Sorina Tugulea;Giuseppina Pennesi;Zhuoru Liu

  • Dual HLA class I and class II restricted recognition of alloreactive T lymphocytes mediated by a single T cell receptor complex.

    Mirjam H. M. Heemskerk;Roelof A. de Paus;Ellie G. A. Lurvink;Frits Koning

  • Human monoclonal HLA antibodies reveal interspecies crossreactive swine MHC class I epitopes relevant for xenotransplantation.

    Arend Mulder;Marrie J. Kardol;J. Scott Arn;Chantal Eijsink

  • Reduced human leukocyte antigen expression in advanced-stage Ewing sarcoma: implications for immune recognition

    Dagmar Berghuis;Alfons S K de Hooge;Susy J Santos;Danielle Horst

  • High-Throughput Characterization of 10 New Minor Histocompatibility Antigens by Whole Genome Association Scanning

    Cornelis A.M. Van Bergen;Caroline E. Rutten;Edith D. Van Der Meijden;Simone A.P. Van Luxemburg-Heijs

  • HLA Class I Antibodies Trigger Increased Adherence of Monocytes to Endothelial Cells by Eliciting an Increase in Endothelial P-Selectin and, Depending on Subclass, by Engaging FcγRs

    Nicole M. Valenzuela;Arend Mulder;Elaine F. Reed

  • Anti-HLA antibodies can induce endothelial cell survival or proliferation depending on their concentration.

    Peter T. Jindra;Xiaohai Zhang;Arend Mulder;Frans Claas

  • The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.

    Marlieke L.M. Jongsma;Antonius A. de Waard;Matthijs Raaben;Tao Zhang

  • Loss or downregulation of HLA class I expression at the allelic level in acute leukemia is infrequent but functionally relevant, and can be restored by interferon.

    Rolf E Brouwer;Pim van der Heiden;Geziena M.T Schreuder;Arend Mulder

  • KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.

    Mohammed M. Naiyer;Sorcha A. Cassidy;Sorcha A. Cassidy;Andrea Magri;Andrea Magri;Vanessa Cowton

  • Differential immunogenicity of HLA mismatches in clinical transplantation.

    Frans H.J. Claas;Marlies K. Dankers;Machteld Oudshoorn;Jon J. van Rood

  • Mannose receptor mediated uptake of antigens strongly enhances HLA-class II restricted antigen presentation by cultured dendritic cells.

    Tan Mc;Mommaas Am;Drijfhout Jw;Jordens R

Frequent Co-Authors

Frans H.J. Claas
Frans H.J. Claas Leiden University Medical Center
Dave L. Roelen
Dave L. Roelen Leiden University Medical Center
Ilias I.N. Doxiadis
Ilias I.N. Doxiadis Leiden University Medical Center
Rene J. Duquesnoy
Rene J. Duquesnoy University of Pittsburgh
Elaine F. Reed
Elaine F. Reed University of California, Los Angeles
Mirjam H.M. Heemskerk
Mirjam H.M. Heemskerk Leiden University Medical Center
William H. Hildebrand
William H. Hildebrand University of Oklahoma Health Sciences Center
Frits Koning
Frits Koning Leiden University Medical Center
Soldano Ferrone
Soldano Ferrone Harvard University
Emmanuel J. H. J. Wiertz
Emmanuel J. H. J. Wiertz Utrecht University

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