World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
17032
World Ranking
9073
National Ranking
122

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

His primary areas of investigation include Cell biology, Bruton's tyrosine kinase, Molecular biology, Antibody and Immunology. His Cell biology research incorporates elements of Microvesicles, Biochemistry, Transfection and In vivo. His work deals with themes such as Kinase and Gene, which intersect with Bruton's tyrosine kinase.

The concepts of his Molecular biology study are interwoven with issues in Alpha, In vitro, Immunoglobulin A, Gene silencing and Transforming growth factor beta. His biological study spans a wide range of topics, including Spleen, Messenger RNA and Pokeweed mitogen. His study in Immunology is interdisciplinary in nature, drawing from both Genetic inheritance and Gene deletion.

His most cited work include:

  • The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases (1181 citations)
  • Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting (510 citations)
  • Cells release subpopulations of exosomes with distinct molecular and biological properties (425 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Molecular biology, Bruton's tyrosine kinase, Genetics, Immunology and Antibody. He has researched Molecular biology in several fields, including Gene expression, Virology, Oligonucleotide, DNA and Polyclonal antibodies. His Bruton's tyrosine kinase research is multidisciplinary, incorporating elements of Cancer research and Kinase.

His research links Antigen with Antibody. He interconnects Pleckstrin homology domain and Proto-oncogene tyrosine-protein kinase Src in the investigation of issues within Tyrosine kinase. His studies link Biochemistry with Cell biology.

He most often published in these fields:

  • Molecular biology (31.80%)
  • Bruton's tyrosine kinase (23.37%)
  • Genetics (20.69%)

What were the highlights of his more recent work (between 2012-2021)?

  • Oligonucleotide (13.79%)
  • Cell biology (14.94%)
  • Bruton's tyrosine kinase (23.37%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Oligonucleotide, Cell biology, Bruton's tyrosine kinase, Genetics and Biochemistry. C. I. Edvard Smith combines subjects such as Biophysics, Nucleic acid and Transfection with his study of Oligonucleotide. His Cell biology research integrates issues from Gene expression and Dystrophin.

His Bruton's tyrosine kinase research is included under the broader classification of Tyrosine kinase. His Genetics research focuses on Disease and how it connects with Gene targeting and B cell. His work is dedicated to discovering how Locked nucleic acid, Electrophoretic mobility shift assay are connected with Molecular biology and other disciplines.

Between 2012 and 2021, his most popular works were:

  • Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting (510 citations)
  • Cells release subpopulations of exosomes with distinct molecular and biological properties (425 citations)
  • Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties (277 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

His main research concerns Genetics, Oligonucleotide, Biochemistry, Nucleic acid and Bruton's tyrosine kinase. His Oligonucleotide study incorporates themes from Genetic therapy, RNA interference and Pharmacology. His Nucleic acid research is multidisciplinary, relying on both Locked nucleic acid and Duplex, DNA.

To a larger extent, he studies Tyrosine kinase with the aim of understanding Bruton's tyrosine kinase. His Tyrosine kinase research is multidisciplinary, incorporating perspectives in Molecular biology, Transgene, Phosphorylation and Morpholino. The various areas that he examines in his Gene study include Antibody and Disease.

Best Publications

  • Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting

    Oscar P. B. Wiklander;Joel Z. Nordin;Aisling O'Loughlin;Ylva Gustafsson

  • Cells release subpopulations of exosomes with distinct molecular and biological properties

    Eduard Willms;Henrik J. Johansson;Imre Mäger;Imre Mäger;Yi Lee

  • Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes

    J. D. Thomas;P. Sideras;C. I. E. Smith;I. Vorechovsky

  • Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

    Joel Z. Nordin;Yi Lee;Pieter Vader;Imre Mäger;Imre Mäger

  • Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.

    Abdalla J. Mohamed;Liang Yu;Carl-Magnus Bäckesjö;Leonardo Vargas

  • Early and prolonged intravenous immunoglobulin replacement therapy in childhood agammaglobulinemia: a retrospective survey of 31 patients.

    Pierre Quartier;Marianne Debré;Jacques De Blic;Rodolphe de Sauverzac

  • Interleukin 4 induces synthesis of IgE and IgG4 in human B cells.

    Mats Lundgren;Ulla Persson;Ulla Persson;Per Larsson;Carl Magnusson

  • Subcutaneous immunoglobulin replacement in patients with primary antibody deficiencies: safety and costs

    A.Gardulf Rn;L Hammarström;R Gustafson;T Nyström

  • Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo.

    Samir E L Andaloussi;Taavi Lehto;Imre Mäger;Katri Rosenthal-Aizman

  • Oligonucleotide Therapies: The Past and the Present.

    Karin E. Lundin;Olof Gissberg;C.I. Edvard Smith

  • Home treatment of hypogammaglobulinaemia with subcutaneous gammaglobulin by rapid infusion.

    L. Hammarstrom;A. Gardulf;C.I. Edvard Smith

  • Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.

    Jessica M Lindvall;K Emelie M Blomberg;Jouni Väliaho;Leonardo Vargas

  • BTKbase: the mutation database for X-linked agammaglobulinemia

    Jouni Väliaho;C.I. Edvard Smith;Mauno Vihinen

  • Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels.

    Atfa Sassi;Sandra Lazaroski;Gang Wu;Stuart M. Haslam

  • Safety and efficacy of the mRNA BNT162b2 vaccine against SARS-CoV-2 in five groups of immunocompromised patients and healthy controls in a prospective open-label clinical trial.

    Peter Bergman;Peter Bergman;Ola Blennow;Ola Blennow;Lotta Hansson;Lotta Hansson;Stephan Mielke;Stephan Mielke

  • The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival.

    Xiao Wang;A. Charlotta Asplund;Anna Porwit;Jenny Flygare

  • Dual Functions of Bruton’s Tyrosine Kinase and Tec Kinase during Fcγ Receptor-Induced Signaling and Phagocytosis

    Jenny Jongstra-Bilen;Jenny Jongstra-Bilen;Adrianet Puig Cano;Manvi Hasija;Haiyan Xiao

  • TGF-beta 1 induces germ-line transcripts of both IgA subclasses in human B lymphocytes.

    Khalid B. Islam;Lars Nilsson;Paschalis Sideras;Lennart Hammarström

  • Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy.

    Taavi Lehto;Rachida Abes;Nikita Oskolkov;Julia Suhorutsenko

  • Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects.

    H. Yesid Estupiñán;H. Yesid Estupiñán;Anna Berglöf;Rula Zain;C. I. Edvard Smith

Frequent Co-Authors

Lennart Hammarström
Lennart Hammarström Karolinska Institute
Samir El Andaloussi
Samir El Andaloussi Karolinska Institute
Mauno Vihinen
Mauno Vihinen Lund University
Jesper Wengel
Jesper Wengel Aalborg University
Birger Christensson
Birger Christensson Karolinska Institute
Matthew J.A. Wood
Matthew J.A. Wood University of Oxford
Ülo Langel
Ülo Langel Stockholm University
Lennart Nilsson
Lennart Nilsson Karolinska Institute
Hans D. Ochs
Hans D. Ochs University of Washington
Paschalis Sideras
Paschalis Sideras Academy of Athens

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