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D-Index
51
Citations
7407
World Ranking
14168
National Ranking
33

Overview

Toh-Seok Kam is a researcher affiliated with the University of Malaya in Malaysia. Their work spans multiple scientific fields, primarily focusing on biochemistry, genetics and molecular biology, materials science, and chemistry. These fields integrate studies on biochemical processes and molecular structures alongside materials development and chemical analysis.

The scientist's main subfields of study include materials chemistry, molecular biology, pharmacology, organic chemistry, and biochemistry. This multidisciplinary approach supports extensive research on alkaloids, crystallization processes, and bioanalytical techniques.

Toh-Seok Kam has contributed to topics such as:

  • Alkaloids: synthesis and pharmacology
  • Traditional and Medicinal Uses of Annonaceae
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Berberine and alkaloids research
  • Chemical synthesis and alkaloids
  • Advanced biosensing and bioanalysis techniques

Some of the recent papers authored or co-authored by Toh-Seok Kam include:

  • Apoferritin-Encapsulated Jerantinine A for Transferrin Receptor Targeting and Enhanced Selectivity in Breast Cancer Therapy, 2022, ACS Omega
  • The Bisindole Alkaloids Angustilongines M and A from Alstonia penangiana Induce Mitochondrial Apoptosis and G0/G1 Cell Cycle Arrest in HT-29 Cells through Promotion of Tubulin Polymerization, 2021, Journal of Natural Products
  • The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-Jun, 2020, BMC Cancer
  • Macroline, talpinine, and sarpagine alkaloids from Alstonia penangiana. An NMR-based method for differentiating between A. penangiana and A. macrophylla, 2020, Phytochemistry
  • Arbolodinines A−C, biologically-active aspidofractinine-aspidofractinine, aspidofractinine-strychnan, and kopsine-strychnan bisindole alkaloids from Kopsia arborea, 2020, Tetrahedron

The researcher often collaborates with other scientists, with frequent co-authors including Yun-Yee Low, Kuan-Hon Lim, Siew-Huah Lim, Tracey D. Bradshaw, and Chun Hoe Tan.

Publication venues where Toh-Seok Kam regularly appears include The Cambridge Structural Database, Angewandte Chemie, ACS Omega, Journal of Natural Products, and Phytochemistry, reflecting a broad range of scientific journals in chemistry and molecular biology.

Best Publications

  • Biologically active indole alkaloids from Kopsia arborea.

    Kuan-Hon Lim;Osamu Hiraku;Kanki Komiyama;Takashi Koyano

  • Alkaloids from Kopsia griffithii

    Toh-Seok Kam;Kooi-Mow Sim

  • Biologically Active Aspidofractinine, Rhazinilam, Akuammiline, and Vincorine Alkaloids from Kopsia

    G Subramaniam;Osamu Hiraku;Masahiko Hayashi;Takashi Koyano

  • Lundurines A, B and C, new indole alkaloids with a novel carbon skeleton containing a cyclopropyl moiety

    Toh-Seok Kam;K. Yoganathan;Cheng-Hock Chuah

  • Bipleiophylline, an unprecedented cytotoxic bisindole alkaloid constituted from the bridging of two indole moieties by an aromatic spacer unit.

    Toh-Seok Kam;Shin-Jowl Tan;Seik-Weng Ng;Kanki Komiyama

  • Mersicarpine, an unusual tetracyclic dihydroindole alkaloid incorporating a seven-membered imine ring

    Toh-Seok Kam;G Subramaniam;Kuan-Hon Lim;Yeun-Mun Choo

  • Leishmanicidal alkaloids from Kopsia griffithii

    Toh-Seok Kam;Kooi-Mow Sim;Takashi Koyano;Kanki Komiyama

  • Lundurines A-D, cytotoxic indole alkaloids incorporating a cyclopropyl moiety from Kopsia tenuis and revision of the structures of tenuisines A-C

    Toh-Seok Kam;Kuan-Hon Lim;K. Yoganathan;Masahiko Hayashi

  • Jerantinines A−G, Cytotoxic Aspidosperma Alkaloids from Tabernaemontana corymbosa

    Kuan-Hon Lim;Osamu Hiraku;Kanki Komiyama;Toh-Seok Kam

  • Alkaloids from Kopsia dasyrachis

    Toh-Seok Kam;G Subramaniam;Wei Chen

  • Plumeran alkaloids from Kopsia profunda

    Toh-Seok Kam;Poh-Suan Tan

  • Grandilodines A−C, Biologically Active Indole Alkaloids from Kopsia grandifolia

    Wai-Sum Yap;Chew-Yan Gan;Yun-Yee Low;Yeun-Mun Choo

  • Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells.

    Hiroo Hasegawa;Yasuaki Yamada;Kanki Komiyama;Masahiko Hayashi

  • Conophylline and Conophyllidine: New Dimeric Alkaloids from Tabernaemontana divaricata

    Toh-Seok Kam;Kah-Yeng Loh;Chen Wei

  • Biologically active ibogan and vallesamine derivatives from Tabernaemontana divaricata.

    Toh-Seok Kam;Huey-Shen Pang;Yeun-Mun Choo;Kanki Komiyama

  • Arboflorine, an unusual pentacyclic monoterpenoid indole alkaloid incorporating a third nitrogen atom.

    Kuan-Hon Lim;Toh-Seok Kam

  • Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata

    Toh-Seok Kam;Huey-Shen Pang;Tuck-Meng Lim

  • Tronocarpine, a novel pentacyclic indole incorporating a seven-membered lactam moiety

    Toh-Seok Kam;Kooi-Mow Sim;Tuck-Meng Lim

  • Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia.

    Siew-Huah Lim;Kooi-Mow Sim;Zanariah Abdullah;Osamu Hiraku

  • Oxidized derivatives of macroline, sarpagine, and pleiocarpamine alkaloids from Alstonia angustifolia.

    Shin-Jowl Tan;Jun-Lee Lim;Yun-Yee Low;Kae-Shin Sim

  • New indole alkaloids from Alstonia macrophylla.

    Toh-Seok Kam;Yeun-Mun Choo

  • Alkaloids from Malaysian Flora

    Toh-Seok Kam

Frequent Co-Authors

Seik Weng Ng
Seik Weng Ng University of Malaya
Gerald Pattenden
Gerald Pattenden University of Nottingham
Nobuyuki Harada
Nobuyuki Harada Tohoku University
Martyn C. R. Symons
Martyn C. R. Symons De Montfort University
Michel O. Steinmetz
Michel O. Steinmetz Paul Scherrer Institute
Toshiyuki Sakai
Toshiyuki Sakai Kyoto Prefectural University of Medicine
Itaru Kojima
Itaru Kojima Gunma University
Brian J. Smith
Brian J. Smith QIMR Berghofer Medical Research Institute
Kazuyuki Sugahara
Kazuyuki Sugahara Hokkaido University
Shimeru Kamihira
Shimeru Kamihira Nagasaki University

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