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Mariko Kitajima

Mariko Kitajima

D-Index & Metrics

Chemistry

D-Index
42
Citations
6404
World Ranking
17537
National Ranking
1389

Overview

Mariko Kitajima is affiliated with Chiba University in Japan, focusing on research in biochemistry, genetics and molecular biology, chemistry, and pharmacology, toxicology and pharmaceutics. Their work spans several subfields including organic chemistry, pharmacology, molecular biology, biochemistry, and materials chemistry.

The scientist's research primarily covers topics related to alkaloids, particularly their synthesis and pharmacology. Other key areas include traditional and medicinal uses of Annonaceae, chemical synthesis and alkaloids, natural product bioactivities and synthesis, cholinesterase and neurodegenerative diseases, asymmetric synthesis and catalysis, and the synthesis and reactivity of heterocycles.

Frequent coauthors in their publications include Hayato Ishikawa, Jukiya Sakamoto, Hiromitsu Takayama, Shinya Shiomi, and Kenta Rakumitsu.

Kitajima has published extensively in several prestigious journals, with many papers appearing in:

  • Chemistry - A European Journal
  • Chemical and Pharmaceutical Bulletin
  • Organic Letters
  • The Journal of Organic Chemistry
  • Synlett

Selected recent papers include:

  • Asymmetric Total Syntheses of Mitragynine, Speciogynine, and 7-Hydroxymitragynine, 2022, Chemical and Pharmaceutical Bulletin
  • Total Syntheses of (+)-Villocarine A, (−)-Apogeissoschizine, and (+)-Geissoschizine, 2023, Chemistry - A European Journal
  • Divergent Total Syntheses of Hetero-Oligomeric Iridoid Glycosides, 2023, Organic Letters
  • Secorubenine, a Monoterpenoid Indole Alkaloid Glycoside from Adina rubescens: Isolation, Structure Elucidation, and Enantioselective Total Synthesis, 2022, Chemical and Pharmaceutical Bulletin
  • Collective Total Synthesis of β-Carboline-Type Monoterpenoid Indole Alkaloid Glycosides, 2023, Synlett

Best Publications

  • Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte

    Tai-Hyun Kang;Kinzo Matsumoto;Michihisa Tohda;Yukihisa Murakami

  • Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.

    Hiromitsu Takayama;Hayato Ishikawa;Mika Kurihara;Mariko Kitajima

  • Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes.

    Tai-Hyun Kang;Yukihisa Murakami;Kinzo Matsumoto;Hiromitsu Takayama

  • Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L.

    Deny Susanti Deny Susanti;Hasnah Mohd. Sirat;Farediah Ahmad;Rasadah Mat Ali

  • A New Indole Alkaloid, 7 alpha-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand.

    Dhavadee Ponglux;Sumphan Wongseripipatana;Hiromitsu Takayama;Masae Kikuchi

  • Two new tryptamine-derived alkaloids from Chimonanthus praecox f. concolor

    Mariko Kitajima;Ikue Mori;Kazumichi Arai;Noriyuki Kogure

  • Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila

    K. Saito;H. Sudo;M. Yamazaki;M. Koseki-Nakamura

  • Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action

    Tai-Hyun Kang;Yukihisa Murakami;Hiromitsu Takayama;Mariko Kitajima

  • Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants.

    Yasuyo Yamazaki;Akiko Urano;Hiroshi Sudo;Mariko Kitajima

  • New type of trimeric and pentameric indole alkaloids from Psychotria rostrata.

    Hiromitsu Takayama;Ikue Mori;Mariko Kitajima;Norio Aimi

  • Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae)

    Euis H. Hakim;Sjamsul A. Achmad;Lia D. Juliawaty;Lukman Makmur

  • Simultaneous analysis of mitragynine, 7-hydroxymitragynine, and other alkaloids in the psychotropic plant “kratom” ( Mitragyna speciosa ) by LC-ESI-MS

    Ruri Kikura-Hanajiri;Maiko Kawamura;Takuro Maruyama;Mariko Kitajima

  • First total synthesis of trimeric indole alkaloid, psychotrimine.

    Yohei Matsuda;Mariko Kitajima;Hiromitsu Takayama

  • Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells.

    Mariko Kitajima;Tomonori Nakamura;Noriyuki Kogure;Mio Ogawa

  • Metabolomics-oriented isolation and structure elucidation of 37 compounds including two anthocyanins from Arabidopsis thaliana.

    Ryo Nakabayashi;Miyako Kusano;Makoto Kobayashi;Takayuki Tohge

  • Involvement of μ-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa

    Kenjiro Matsumoto;Yoshio Hatori;Toshihiko Murayama;Kimihito Tashima

  • Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose

    Yasuyo Yamazaki;Mariko Kitajima;Masanori Arita;Hiromitsu Takayama

  • Lycopodium alkaloids: isolation and asymmetric synthesis.

    Mariko Kitajima;Hiromitsu Takayama

  • Isolation, structure elucidation, and total synthesis of two new Chimonanthus alkaloids, chimonamidine and chimonanthidine

    Hiromitsu Takayama;Yohei Matsuda;Kyohei Masubuchi;Atsushi Ishida

  • Asymmetric Total Synthesis of a Pentacyclic Lycopodium Alkaloid: Huperzine‐Q

    Atsushi Nakayama;Noriyuki Kogure;Mariko Kitajima;Hiromitsu Takayama

  • New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives.

    Yosuke Toriizuka;Eri Kinoshita;Noriyuki Kogure;Mariko Kitajima

  • Chemical studies on monoterpenoid indole alkaloids from medicinal plant resources Gelsemium and Ophiorrhiza

    Mariko Kitajima

  • Structure reinvestigation of gelsemoxonine, a constituent of Gelsemium elegans, reveals a novel, azetidine-containing indole alkaloid

    Mariko Kitajima;Noriyuki Kogure;Kentaro Yamaguchi;Hiromitsu Takayama

  • First asymmetric total syntheses of cernuane-type Lycopodium alkaloids, cernuine, and cermizine D.

    Yasuhiro Nishikawa;Mariko Kitajima;Hiromitsu Takayama

  • A divergent approach for the total syntheses of cernuane-type and quinolizidine-type Lycopodium alkaloids

    Yasuhiro Nishikawa;Mariko Kitajima;Noriyuki Kogure;Hiromitsu Takayama

  • Four Novel Gelsenicine-Related Oxindole Alkaloids from the Leaves of Gelsemium elegans Benth.†

    Noriyuki Kogure;Naoko Ishii;Mariko Kitajima;Sumphan Wongseripipatana

  • Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test.

    Mohamed A.‐F. Abdel‐Fattah;Kinzo Matsumoto;Keiichi Tabata;Hiromitsu Takayama

  • MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: A novel dual-acting μ- and κ-opioid agonist with potent antinociceptive and weak rewarding effects in mice

    Kenjiro Matsumoto;Hiromitsu Takayama;Minoru Narita;Atsushi Nakamura

  • Structure characterization, biomimetic total synthesis and optical purity of two new pyrrolidine alkaloids, pandamarilactonine-a and -b, isolated from Pandanus amaryllifolius Roxb

    Hiromitsu Takayama;Tomotake Ichikawa;Toshiyuki Kuwajima;Mariko Kitajima

Frequent Co-Authors

Hiromitsu Takayama
Hiromitsu Takayama Chiba University
Joachim Stöckigt
Joachim Stöckigt Zhejiang University
Kentaro Yamaguchi
Kentaro Yamaguchi Tokushima Bunri University
Hayato Ishikawa
Hayato Ishikawa Kumamoto University
Mami Yamazaki
Mami Yamazaki Chiba University
Kazuei Igarashi
Kazuei Igarashi Chiba University
Keiko Kashiwagi
Keiko Kashiwagi Chiba Institute of Science
Yukihiro Goda
Yukihiro Goda Ministry of Health Labour and Welfare
Scott G. Franzblau
Scott G. Franzblau University of Illinois at Chicago

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