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Hiromitsu Takayama

Hiromitsu Takayama

D-Index & Metrics

Chemistry

D-Index
68
Citations
15463
World Ranking
6573
National Ranking
429

Overview

Hiromitsu Takayama is affiliated with Chiba University in Japan and is active in research areas spanning biochemistry, genetics, molecular biology, and chemistry. Their publications reflect a focus on molecular biology and organic chemistry, with notable involvement also in pharmacology, biochemistry, and materials chemistry.

The scientist's research topics concentrate on various aspects of chemical synthesis and alkaloids, cholinesterase and neurodegenerative diseases, as well as alkaloids' synthesis and pharmacology. Other topics include traditional and medicinal uses of Annonaceae, sulfur compounds in biology, redox biology and oxidative stress, and glutathione transferases and polymorphisms.

Frequent collaborators include Mariko Kitajima, Hayato Ishikawa, Shinya Shiomi, Noriyuki Kogure, and Wilailak Kaewsri.

Key publication venues in which Takayama has contributed include:

  • The Journal of Organic Chemistry (2 publications)
  • Journal of Synthetic Organic Chemistry Japan (2 publications)
  • Analytical Methods (1 publication)
  • Chemical and Pharmaceutical Bulletin (1 publication)
  • Journal of the American Chemical Society (1 publication)

Recent significant publications by Takayama include:

  • Total Syntheses of Lycopodium and Monoterpenoid Indole Alkaloids Based on Biosynthesis-Inspired Strategies, 2020, Chemical and Pharmaceutical Bulletin

Other notable papers connected with their research field or coauthors but authored by different primary authors include:

  • Simultaneous determination of intracellular reduced and oxidized glutathiones by the König reaction, 2023, Analytical Methods
  • Asymmetric Total Synthesis and Structure Elucidation of Huperzine H, 2022, The Journal of Organic Chemistry
  • New monoterpenoid indole alkaloids from Gelsemium elegans seeds, 2021, Tetrahedron
  • Elucidation of Absolute Configuration of Ophiorrhiside A by Comparison of ECD Spectra with That of Model Chiral Compound Having a 1,2,3,4-Tetrahydro-β-carbolin-3-one Skeleton, 2020, Heterocycles

Takayama's research integrates synthetic chemical approaches to biologically relevant alkaloids, studying both their chemical and pharmacological properties. The scientific output suggests significant intersections with neurodegenerative disease-related biochemical pathways through cholinesterase-related studies and redox biology.

Best Publications

  • Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte

    Tai-Hyun Kang;Kinzo Matsumoto;Michihisa Tohda;Yukihisa Murakami

  • Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa

    Hiromitsu Takayama

  • Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range.

    Yayoi Kobayashi;Yasumitsu Ogra;Kazuya Ishiwata;Hiromitsu Takayama

  • Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.

    Hiromitsu Takayama;Hayato Ishikawa;Mika Kurihara;Mariko Kitajima

  • Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa.

    Kenjiro Matsumoto;Syunji Horie;Hayato Ishikawa;Hiromitsu Takayama

  • Rhynchophylline and isorhynchophylline inhibit NMDA receptors expressed in Xenopus oocytes.

    Tai-Hyun Kang;Yukihisa Murakami;Kinzo Matsumoto;Hiromitsu Takayama

  • A New Indole Alkaloid, 7 alpha-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand.

    Dhavadee Ponglux;Sumphan Wongseripipatana;Hiromitsu Takayama;Masae Kikuchi

  • Characterization of a recently evolved flavonol-phenylacyltransferase gene provides signatures of natural light selection in Brassicaceae

    Takayuki Tohge;Regina Wendenburg;Hirofumi Ishihara;Ryo Nakabayashi

  • Two new tryptamine-derived alkaloids from Chimonanthus praecox f. concolor

    Mariko Kitajima;Ikue Mori;Kazumichi Arai;Noriyuki Kogure

  • Feasible production of camptothecin by hairy root culture of Ophiorrhiza pumila

    K. Saito;H. Sudo;M. Yamazaki;M. Koseki-Nakamura

  • Identification of a novel selenium metabolite, Se-methyl-N-acetylselenohexosamine, in rat urine by high-performance liquid chromatography-inductively coupled plasma mass spectrometry and -electrospray ionization tandem mass spectrometry

    Yasumitsu Ogra;Kazuya Ishiwata;Hiromitsu Takayama;Norio Aimi

  • Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action

    Tai-Hyun Kang;Yukihisa Murakami;Hiromitsu Takayama;Mariko Kitajima

  • Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants.

    Yasuyo Yamazaki;Akiko Urano;Hiroshi Sudo;Mariko Kitajima

  • New type of trimeric and pentameric indole alkaloids from Psychotria rostrata.

    Hiromitsu Takayama;Ikue Mori;Mariko Kitajima;Norio Aimi

  • Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae)

    Euis H. Hakim;Sjamsul A. Achmad;Lia D. Juliawaty;Lukman Makmur

  • Simultaneous analysis of mitragynine, 7-hydroxymitragynine, and other alkaloids in the psychotropic plant “kratom” ( Mitragyna speciosa ) by LC-ESI-MS

    Ruri Kikura-Hanajiri;Maiko Kawamura;Takuro Maruyama;Mariko Kitajima

  • Dimerization of indole derivatives with hypervalent iodines(III): a new entry for the concise total synthesis of rac- and meso-chimonanthines

    Hayato Ishikawa;Hiromitsu Takayama;Norio Aimi

  • First total synthesis of trimeric indole alkaloid, psychotrimine.

    Yohei Matsuda;Mariko Kitajima;Hiromitsu Takayama

  • Isolation of gelsedine-type indole alkaloids from Gelsemium elegans and evaluation of the cytotoxic activity of gelsemium alkaloids for A431 epidermoid carcinoma cells.

    Mariko Kitajima;Tomonori Nakamura;Noriyuki Kogure;Mio Ogawa

  • Total Synthesis Guided Structure Elucidation of (+)‐Psychotetramine

    Klement Foo;Timothy Newhouse;Ikue Mori;Hiromitsu Takayama

  • Metabolomics-oriented isolation and structure elucidation of 37 compounds including two anthocyanins from Arabidopsis thaliana.

    Ryo Nakabayashi;Miyako Kusano;Makoto Kobayashi;Takayuki Tohge

Frequent Co-Authors

Mariko Kitajima
Mariko Kitajima Chiba University
Hayato Ishikawa
Hayato Ishikawa Kumamoto University
Kentaro Yamaguchi
Kentaro Yamaguchi Tokushima Bunri University
Kazuei Igarashi
Kazuei Igarashi Chiba University
Hiroshi Watanabe
Hiroshi Watanabe Niigata University
Mami Yamazaki
Mami Yamazaki Chiba University
Keiko Kashiwagi
Keiko Kashiwagi Chiba Institute of Science
Kazuo T. Suzuki
Kazuo T. Suzuki Chiba University
Elaine Holmes
Elaine Holmes Imperial College London

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