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Molecular Biology

D-Index
56
Citations
14701
World Ranking
2192
National Ranking
1089

Overview

Robert M. Kotin is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research contributions primarily fall within the field of Biochemistry, Genetics and Molecular Biology, with a focus on genetics and molecular biology subfields. The scientist's work engages with a range of topics that include virus-based gene therapy research, animal virus infection studies, viral infectious diseases and gene expression in insects, bioluminescence and chemiluminescence research, Parvovirus B19 infection studies, crystallization and solubility studies, and field-flow fractionation techniques.

The frequent coauthors collaborating with Robert M. Kotin are Paul W. Barone, Stacy L. Springs, Anthony J. Sinskey, Richard D. Braatz, and Jacqueline M. Wolfrum.

The scientist has published frequently in venues such as arXiv (Cornell University), bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, Virus Evolution, and Molecular Therapy - Methods & Clinical Development.

Selected recent publications include:

  • Evolution of dependoparvoviruses across geological timescales-implications for design of AAV-based gene therapy vectors (2020), Virus Evolution
  • Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system (2023), Molecular Therapy - Methods & Clinical Development
  • Comparative analysis reveals the long-term coevolutionary history of parvoviruses and vertebrates (2022), PLoS Biology
  • Development of evolutionarily conserved viral integration sites as safe harbors for human gene therapy (2023), bioRxiv (Cold Spring Harbor Laboratory)
  • An Integrated Experimental and Modeling Approach for Crystallization of Complex Biotherapeutics (2025), Crystal Growth & Design

Best Publications

  • Recombinant adeno-associated virus type 2, 4, and 5 vectors: Transduction of variant cell types and regions in the mammalian central nervous system

    Beverly L. Davidson;Colleen S. Stein;Jason A. Heth;Inês Martins

  • RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model.

    Scott Q. Harper;Patrick D. Staber;Xiaohua He;Steven L. Eliason

  • RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia

    Haibin Xia;Qinwen Mao;Steven L Eliason;Scott Q Harper

  • Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination.

    R.M. Kotin;R.M. Linden;K.I. Berns

  • Insect Cells as a Factory to Produce Adeno-Associated Virus Type 2 Vectors

    Masashi Urabe;Chuantian Ding;Robert M. Kotin

  • Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA

    Matthew D. Weitzman;Sirkka R. M. Kyostio;Robert M. Kotin;Roland A. Owens

  • Prospects for the Use of Adeno-Associated Virus as a Vector for Human Gene Therapy

    Robert M. Kotin

  • Cloning and Characterization of Adeno-Associated Virus Type 5

    John A. Chiorini;Frank Kim;Linda Yang;Robert M. Kotin

  • Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter.

    Robert M. Kotin;Joan C. Menninger;David C. Ward;Kenneth I. Berns

  • Adeno-Associated Virus Type 5 (AAV5) but Not AAV2 Binds to the Apical Surfaces of Airway Epithelia and Facilitates Gene Transfer

    Joseph Zabner;Michael Seiler;Robert Walters;Robert M. Kotin

  • Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles.

    John A. Chiorini;Linda Yang;Yuejiang Liu;Brian Safer

  • A Simplified Baculovirus-AAV Expression Vector System Coupled With One-step Affinity Purification Yields High-titer rAAV Stocks From Insect Cells

    Richard H Smith;Justin R Levy;Robert M Kotin

  • Virus-Mediated Transduction of Murine Retina with Adeno-Associated Virus: Effects of Viral Capsid and Genome Size

    Grace S. Yang;Michael Schmidt;Ziying Yan;Jonathan D. Lindbloom

  • Baculovirus: an insect-derived vector for diverse gene transfer applications.

    Kari J Airenne;Yu-Chen Hu;Thomas A Kost;Richard H Smith

  • Production of adeno-associated virus in insect cells

    Robert M. Kotin;Masashi Urabe;Chuan-Tian Ding

  • Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein.

    E Urcelay;P Ward;S M Wiener;B Safer

  • High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors.

    John A. Chiorini;Clemens M. Wendtner;Elena Urcelay;Brian Safer

  • Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep.

    Alison Burgess Hickman;Donald R Ronning;Robert M Kotin;Fred Dyda

  • Organization of adeno-associated virus DNA in latently infected Detroit 6 cells.

    Robert M. Kotin;Kenneth I. Berns

  • Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli.

    J A Chiorini;M D Weitzman;R A Owens;E Urcelay

Frequent Co-Authors

John A. Chiorini
John A. Chiorini National Institutes of Health
Brian Safer
Brian Safer National Institutes of Health
Kenneth I. Berns
Kenneth I. Berns University of Florida
Beverly L. Davidson
Beverly L. Davidson Children's Hospital of Philadelphia
John A. Chiorini
John A. Chiorini National Institutes of Health
Ian E. Alexander
Ian E. Alexander University of Sydney
Henry L. Paulson
Henry L. Paulson University of Michigan–Ann Arbor
Philippe Moullier
Philippe Moullier University of Nantes
Fred Dyda
Fred Dyda National Institutes of Health
Mavis Agbandje-McKenna
Mavis Agbandje-McKenna University of Florida

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