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Molecular Biology

D-Index
69
Citations
18580
World Ranking
1468
National Ranking
29

Overview

Alberto Auricchio is affiliated with the Telethon Institute Of Genetics And Medicine in Italy. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with contributions also made within Medicine. Subfields that feature prominently in their work include Molecular Biology, Genetics, Immunology, Epidemiology, and Physiology.

The scientist's research topics cover a range of areas, notably:

  • Virus-based gene therapy research
  • Retinal Development and Disorders
  • CRISPR and Genetic Engineering
  • RNA regulation and disease
  • Viral Infections and Immunology Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Atherosclerosis and Cardiovascular Diseases

Selected recent publications indicative of their research direction include:

  • "Allele-specific editing ameliorates dominant retinitis pigmentosa in a transgenic mouse model" (2021), published in The American Journal of Human Genetics
  • "Low incidence of hepatocellular carcinoma in mice and cats treated with systemic adeno-associated viral vectors" (2020), published in Molecular Therapy - Methods & Clinical Development
  • "Light-responsive microRNA miR-211 targets Ezrin to modulate lysosomal biogenesis and retinal cell clearance" (2020), published in The EMBO Journal
  • "Therapeutic homology-independent targeted integration in retina and liver" (2022), published in Nature Communications
  • "Large gene delivery to the retina with AAV vectors: are we there yet?" (2020), published in Gene Therapy

Frequent co-authors contributing to their body of work include Edoardo Nusco, Elena Marrocco, Enrico Maria Surace, Rita Ferla, and Margherita Dell'Anno.

The most common venues for publication by Alberto Auricchio consist of Molecular Therapy - Methods & Clinical Development, EMBO Molecular Medicine, Human Gene Therapy, Zenodo (CERN European Organization for Nuclear Research), and Nature Communications.

Best Publications

  • Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

    Albert M. Maguire;Francesca Simonelli;Eric A. Pierce;Edward N. Pugh

  • Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

    Albert M. Maguire;Albert M. Maguire;Katherine A. High;Katherine A. High;Alberto Auricchio;J. Fraser Wright;J. Fraser Wright

  • Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration.

    Francesca Simonelli;Albert M Maguire;Albert M Maguire;Francesco Testa;Eric A Pierce

  • Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial

    Jean Bennett;Jean Bennett;Jennifer Wellman;Kathleen A Marshall;Sarah McCague

  • AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness

    Jean Bennett;Jean Bennett;Manzar Ashtari;Jennifer Wellman;Kathleen A. Marshall

  • Exchange of surface proteins impacts on viral vector cellular specificity and transduction characteristics: the retina as a model

    Alberto Auricchio;Gary Kobinger;Vibha Anand;Markus Hildinger

  • Isolation of highly infectious and pure adeno-associated virus type 2 vectors with a single-step gravity-flow column.

    Alberto Auricchio;Markus Hildinger;Erin O'Connor;Guang-Ping Gao

  • Three-Year Follow-up after Unilateral Subretinal Delivery of Adeno-Associated Virus in Patients with Leber Congenital Amaurosis Type 2

    Francesco Testa;Albert M. Maguire;Albert M. Maguire;Settimio Rossi;Eric A. Pierce

  • Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport

    Fatima Ferreirinha;Angelo Quattrini;Marinella Pirozzi;Valentina Valsecchi

  • Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice

    Mariacarmela Allocca;Monica Doria;Marco Petrillo;Pasqualina Colella

  • Novel Adeno-Associated Virus Serotypes Efficiently Transduce Murine Photoreceptors

    Mariacarmela Allocca;Claudio Mussolino;Maria Garcia-Hoyos;Daniela Sanges

  • MicroRNAs involved in molecular circuitries relevant for the duchenne muscular dystrophy pathogenesis are controlled by the dystrophin/nNOS pathway

    Davide Cacchiarelli;Julie Martone;Erika Girardi;Marcella Cesana

  • Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer

    Markus Hildinger;Alberto Auricchio;Guangping Gao;Lili Wang

  • Effective delivery of large genes to the retina by dual AAV vectors

    Ivana Trapani;Pasqualina Colella;Andrea Sommella;Carolina Iodice

  • Recombinant aav vectors with AAV5 capsids and AAV5 vectors pseudotyped in heterologous capsids

    Markus Hildinger;James M. Wilson;Alberto Auricchio

  • RNA interference-mediated suppression and replacement of human rhodopsin in vivo.

    Mary O’Reilly;Arpad Palfi;Naomi Chadderton;Sophia Millington-Ward

  • Inhibition of retinal neovascularization by intraocular viral-mediated delivery of anti-angiogenic agents

    Alberto Auricchio;Kathryn C. Behling;Albert M. Maguire;Erin E. O'Connor

  • Vector platforms for gene therapy of inherited retinopathies.

    Ivana Trapani;Agostina Puppo;Alberto Auricchio

  • Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes

    Alessandro Fraldi;Kim Hemsley;Allison Crawley;Alessia Lombardi

  • The human visual cortex responds to gene therapy-mediated recovery of retinal function.

    Manzar Ashtari;Laura L. Cyckowski;Justin F. Monroe;Kathleen A. Marshall

Frequent Co-Authors

Jean Bennett
Jean Bennett University of Pennsylvania
James M. Wilson
James M. Wilson University of Pennsylvania
Albert M. Maguire
Albert M. Maguire University of Pennsylvania
Sandro Banfi
Sandro Banfi University of Campania "Luigi Vanvitelli"
Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine
Valeria Marigo
Valeria Marigo University of Modena and Reggio Emilia
J. Fraser Wright
J. Fraser Wright Stanford University
Luciano Domenici
Luciano Domenici University of L'Aquila
Feliciano Protasi
Feliciano Protasi University of Chieti-Pescara

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