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D-Index & Metrics

Molecular Biology

D-Index
44
Citations
21513
World Ranking
2885
National Ranking
1373

Overview

J. Fraser Wright is affiliated with Stanford University in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, focusing extensively on molecular biology and genetics as core subfields.

The scientist's work covers a range of topics, notably:

  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Viral Infectious Diseases and Gene Expression in Insects
  • CRISPR and Genetic Engineering
  • Viral gastroenteritis research and epidemiology
  • RNA Interference and Gene Delivery
  • Viral Infections and Immunology Research

J. Fraser Wright has contributed significantly to several publication venues. Frequent venues include:

  • Molecular Therapy - Methods & Clinical Development
  • Molecular Therapy
  • Cytotherapy
  • Science Translational Medicine
  • Frontiers in Immunology

Their recent papers illustrate a focus on gene therapy and viral vector research. Examples include:

  • "Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease," 2021, Science Translational Medicine
  • "Challenges Posed by Immune Responses to AAV Vectors: Addressing Root Causes," 2021, Frontiers in Immunology
  • "Quality Control Testing, Characterization and Critical Quality Attributes of Adeno-Associated Virus Vectors Used for Human Gene Therapy," 2020, Biotechnology Journal
  • "Codon Modification and PAMPs in Clinical AAV Vectors: The Tortoise or the Hare?" 2020, Molecular Therapy
  • "Quantification of CpG Motifs in rAAV Genomes: Avoiding the Toll," 2020, Molecular Therapy

Co-authorship connections are evident with several researchers, including:

  • Rosa Bacchetta
  • Bruce Alberts
  • Kyriacos Mitrophanous
  • Matthew H. Porteus
  • Yohei Sato

Overall, J. Fraser Wright's body of work contributes to understanding and developing viral vector technology and gene therapy methods within molecular biology and genetics frameworks, furthering areas such as immune responses to viral vectors and gene correction techniques.

Best Publications

  • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.

    Stephan A. Grupp;Michael Kalos;David Barrett;Richard Aplenc

  • Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

    Albert M. Maguire;Francesca Simonelli;Eric A. Pierce;Edward N. Pugh

  • Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

    Manno Cs;Pierce Gf;Arruda Vr;Glader B

  • Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

    Stephen Russell;Jean Bennett;Jennifer A. Wellman;Daniel C. Chung

  • Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial

    Albert M. Maguire;Albert M. Maguire;Katherine A. High;Katherine A. High;Alberto Auricchio;J. Fraser Wright;J. Fraser Wright

  • Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.

    Lindsey A. George;Spencer K. Sullivan;Adam Giermasz;John E.J. Rasko;John E.J. Rasko

  • Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration.

    Francesca Simonelli;Albert M Maguire;Albert M Maguire;Francesco Testa;Eric A Pierce

  • Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial

    Jean Bennett;Jean Bennett;Jennifer Wellman;Kathleen A Marshall;Sarah McCague

  • AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness

    Jean Bennett;Jean Bennett;Manzar Ashtari;Jennifer Wellman;Kathleen A. Marshall

  • Three-Year Follow-up after Unilateral Subretinal Delivery of Adeno-Associated Virus in Patients with Leber Congenital Amaurosis Type 2

    Francesco Testa;Albert M. Maguire;Albert M. Maguire;Settimio Rossi;Eric A. Pierce

  • High AAV vector purity results in serotype- and tissue-independent enhancement of transduction efficiency

    E Ayuso;F Mingozzi;J Montane;X Leon

  • Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials.

    Albert M. Maguire;Albert M. Maguire;Stephen Russell;Jennifer A. Wellman;Daniel C. Chung

  • Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver

    Federico Mingozzi;Nicole C. Hasbrouck;Etiena Basner-Tschakarjan;Shyrie A. Edmonson;Shyrie A. Edmonson

  • Assessing the potential for AAV vector genotoxicity in a murine model

    Hojun Li;Nirav Malani;Shari R. Hamilton;Alexander Schlachterman

  • Progress and challenges in viral vector manufacturing.

    Johannes C.M. van der Loo;J. Fraser Wright

  • Quantification of adeno-associated virus particles and empty capsids by optical density measurement.

    J.ürg M Sommer;Peter H Smith;Sumathy Parthasarathy;Jesse Isaacs

  • Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery.

    Catherine Cukras;Henry E. Wiley;Brett G. Jeffrey;H. Nida Sen

  • Identification of factors that contribute to recombinant AAV2 particle aggregation and methods to prevent its occurrence during vector purification and formulation

    J. Fraser Wright;Tannie Le;Joseph Prado;Jennifer Bahr-Davidson

  • Separation of adeno-associated virus type 2 empty particles from genome containing vectors by anion-exchange column chromatography.

    Guang Qu;Jennifer Bahr-Davidson;Joseph Prado;Alex Tai

  • Pharmacological modulation of humoral immunity in a nonhuman primate model of AAV gene transfer for hemophilia B.

    Federico Mingozzi;Yifeng Chen;Yifeng Chen;Samuel L Murphy;Shyrie C Edmonson;Shyrie C Edmonson

Frequent Co-Authors

Katherine A. High
Katherine A. High Children's Hospital of Philadelphia
Federico Mingozzi
Federico Mingozzi Children's Hospital of Philadelphia
Albert M. Maguire
Albert M. Maguire University of Pennsylvania
Valder R. Arruda
Valder R. Arruda University of Pennsylvania
Jean Bennett
Jean Bennett University of Pennsylvania
Alberto Auricchio
Alberto Auricchio Telethon Institute Of Genetics And Medicine
Eric A. Pierce
Eric A. Pierce Massachusetts Eye and Ear Infirmary
Daniel C. Chung
Daniel C. Chung Harvard University
Edwin M. Stone
Edwin M. Stone University of Iowa
Sandro Banfi
Sandro Banfi University of Campania "Luigi Vanvitelli"

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