2026 Luk H. Vandenberghe: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	63	10123	9347	4427	3980	196	15889

Overview

Luk H. Vandenberghe is affiliated with the Massachusetts Eye and Ear Infirmary in the United States. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine, focusing on topics related to gene therapy and genetic engineering.

The main research areas of Luk H. Vandenberghe include:

Virus-based gene therapy research
CRISPR and genetic engineering
SARS-CoV-2 and COVID-19 research
Hearing, cochlea, tinnitus, and genetics
Viral infectious diseases and gene expression in insects
Hearing loss and rehabilitation
Retinal development and disorders

Their subfields of study comprise molecular biology, genetics, infectious diseases, sensory systems, and physiology.

Significant recent publications authored or coauthored by Vandenberghe include:

Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice, 2023, Nature Medicine
An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates, 2021, Cell Host & Microbe
High-efficiency purification of divergent AAV serotypes using AAVX affinity chromatography, 2022, Molecular Therapy - Methods & Clinical Development
AAV capsid design: A Goldilocks challenge, 2022, Trends in Molecular Medicine
Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate, 2022, Nature Communications

Frequent coauthors with whom Vandenberghe has collaborated include:

Nerea Zabaleta
Julio Sanmiguel
Urja Bhatt
Reynette Estelien
Cheikh Tacko Diop

Vandenberghe has published extensively in several venues, with multiple contributions to:

Molecular Therapy - Methods & Clinical Development
UNC Libraries
bioRxiv (Cold Spring Harbor Laboratory)
Human Molecular Genetics
Molecular Therapy - Nucleic Acids

Best Publications

Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

Guangping Gao;Luk H. Vandenberghe;Mauricio R. Alvira;You Lu

1320
Citations
In vivo gene editing in dystrophic mouse muscle and muscle stem cells

Mohammadsharif Tabebordbar;Kexian Zhu;Jason K. W. Cheng;Wei Leong Chew

1140
Citations
Worldwide Epidemiology of Neutralizing Antibodies to Adeno-Associated Viruses

Roberto Calcedo;Luk H. Vandenberghe;Guangping Gao;Jianping Lin

917
Citations
New recombinant serotypes of AAV vectors.

Guangping Gao;Luk H. Vandenberghe;James M. Wilson

598
Citations
DC-SIGN and DC-SIGNR bind ebola glycoproteins and enhance infection of macrophages and endothelial cells.

Graham Simmons;Jacqueline D. Reeves;Case C. Grogan;Luk H. Vandenberghe

455
Citations
Adeno-associated viruses undergo substantial evolution in primates during natural infections.

Guangping Gao;Mauricio R. Alvira;Suryanarayan Somanathan;You Lu

447
Citations
Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale

Martin Lock;Mauricio Alvira;Luk H. Vandenberghe;Arabinda Samanta

381
Citations
Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality

Eloise Hudry;Luk H. Vandenberghe

349
Citations
Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain.

Jean-Marc Taymans;Luk H Vandenberghe;Chris Van Den Haute;Irina Thiry

341
Citations
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

Lukas D Landegger;Lukas D Landegger;Lukas D Landegger;Bifeng Pan;Bifeng Pan;Charles Askew;Charles Askew;Charles Askew;Sarah J Wassmer;Sarah J Wassmer

328
Citations
In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector

Eric Zinn;Eric Zinn;Simon Pacouret;Simon Pacouret;Vadim Khaychuk;Vadim Khaychuk;Heikki T. Turunen;Heikki T. Turunen

315
Citations
Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c

Bifeng Pan;Charles Askew;Charles Askew;Alice Galvin;Selena Heman-Ackah;Selena Heman-Ackah

297
Citations
Novel Adeno-Associated Virus Serotypes Efficiently Transduce Murine Photoreceptors

Mariacarmela Allocca;Claudio Mussolino;Maria Garcia-Hoyos;Daniela Sanges

293
Citations
Progress in gene therapy for neurological disorders

Michele Simonato;Jean Bennett;Nicholas M. Boulis;Maria G. Castro

271
Citations
Dosage Thresholds for AAV2 and AAV8 Photoreceptor Gene Therapy in Monkey

Luk H. Vandenberghe;Peter Bell;Albert M. Maguire;Albert M. Maguire;Cassia N. Cearley;Cassia N. Cearley

267
Citations
Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver

Ekaterina Breous;Suryanarayan Somanathan;Luk H. Vandenberghe;James M. Wilson

249
Citations
Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid

Luk H Vandenberghe;Lili Wang;Suryanarayan Somanathan;Yan Zhi

248
Citations
The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice

Christie L. Bell;Luk H. Vandenberghe;Peter Bell;Maria P. Limberis

227
Citations
In vitro and in vivo rescue of aberrant splicing in CEP290-associated LCA by antisense oligonucleotide delivery

Alejandro Garanto;Daniel C. Chung;Lonneke Duijkers;Julio C. Corral-Serrano

218
Citations
In vivo gene editing in dystrophic mouse muscle and muscle stem cells

M. Tabebordbar;K. Zhu;J. K. W. Cheng;W. L. Chew

2
Citations