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Biology and Biochemistry

D-Index
62
Citations
12660
World Ranking
10883
National Ranking
4717

Overview

Kim E. Barrett is affiliated with the University of California, San Diego in the United States. Their research primarily spans the fields of medicine and biochemistry, genetics, and molecular biology. Within these domains, Barrett's work touches on several subfields, including molecular biology, surgery, genetics, gastroenterology, and neurology.

The scientist has contributed significantly to topics related to gut microbiota and health, digestive system and related health, Helicobacter pylori-related gastroenterology studies, inflammatory bowel disease, gastrointestinal motility and disorders, barrier structure and function studies, as well as probiotics and fermented foods.

Barrett's recent publications cover a range of topics in gastrointestinal physiology and intestinal barrier function. Notable recent papers include:

  • Intestinal secretory mechanisms and diarrhea (2022, American Journal of Physiology-Gastrointestinal and Liver Physiology)
  • A prebiotic fructo-oligosaccharide promotes tight junction assembly in intestinal epithelial cells via an AMPK-dependent pathway (2020, Biomedicine & Pharmacotherapy)
  • T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling (2021, Journal of Clinical Investigation)
  • Potentiation of calcium-activated chloride secretion and barrier dysfunction may underlie EGF receptor tyrosine kinase inhibitor-induced diarrhea (2020, Physiological Reports)
  • Claudin-2 pore causes leak that breaches the dam in intestinal inflammation (2020, Journal of Clinical Investigation)

Frequent coauthors of Barrett include Andrew Quach, Stephen J. Keely, Mamata Sivagnanam, Barun Das, and John Rabalais. The scientist has published repeatedly in venues such as The Journal of Physiology, Gastroenterology, Cellular and Molecular Gastroenterology and Hepatology, The FASEB Journal, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Live probiotics protect intestinal epithelial cells from the effects of infection with enteroinvasive Escherichia coli (EIEC)

    S Resta-Lenert;K E Barrett

  • Ganong's Review of Medical Physiology

    Kim E. Barrett

  • Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects.

    Kim E. Barrett;Stephen J. Keely

  • Probiotics and Commensals Reverse TNF-α– and IFN-γ–Induced Dysfunction in Human Intestinal Epithelial Cells

    Silvia C. Resta-Lenert;Kim E. Barrett

  • Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production.

    Lars Eckmann;William F. Stenson;Tor C. Savidge;David C. Lowe

  • Inhibition of Ca2+-dependent Cl- secretion in T84 cells : membrane target(s) of inhibition is agonist specific

    Kim E. Barrett;Jane Smitham;Alexis Traynor-Kaplan;Jorge M. Uribe

  • Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4.

    Mana Vajanaphanich;Carsten Schultz;Marco T. Rudolf;Matthew Wasserman

  • Carbachol-stimulated Transactivation of Epidermal Growth Factor Receptor and Mitogen-activated Protein Kinase in T84 Cells Is Mediated by Intracellular Ca2+, PYK-2, and p60 src

    Stephen J. Keely;Sean O. Calandrella;Kim E. Barrett

  • Positive and negative regulation of chloride secretion in T84 cells

    K. E. Barrett

  • Carbachol Stimulates Transactivation of Epidermal Growth Factor Receptor and Mitogen-activated Protein Kinase in T84Cells IMPLICATIONS FOR CARBACHOL-STIMULATED CHLORIDE SECRETION

    Stephen J. Keely;Jorge M. Uribe;Kim E. Barrett

  • Activation of mast cells by bile acids

    Richard G. Quist;Huong-Thu Ton-Nu;Jan Lillienau;Alan F. Hofmann

  • Mast cell numbers and histamine levels in synovial fluids from patients with diverse arthritides.

    Daniel G. Malone;Daniel G. Malone;Anne-Marie Irani;Anne-Marie Irani;Lawrence B. Schwartz;Lawrence B. Schwartz;Kim E. Barrett;Kim E. Barrett

  • Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells.

    M R Hoda;S J Keely;L S Bertelsen;W G Junger

  • Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells

    Jürgen Stein;Jürgen Ries;Kim E. Barrett

  • Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice

    Carli J. Smith;Jacob R. Emge;Katrina Berzins;Lydia Lung

  • Protection of Epithelial Barrier Function by the Crohn's Disease Associated Gene Protein Tyrosine Phosphatase N2

    Michael Scharl;Gisela Paul;Achim Weber;Barbara C. Jung

  • Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a -/- mice

    Silvia Resta-Lenert;Jane Smitham;Kim E. Barrett

  • Modulation of the microbiota-gut-brain axis by probiotics in a murine model of inflammatory bowel disease

    Jacob R. Emge;Kevin Huynh;Elaine N. Miller;Manvir Kaur

  • Transactivation of the Epidermal Growth Factor Receptor in Colonic Epithelial Cells by Carbachol Requires Extracellular Release of Transforming Growth Factor-α

    Declan F. McCole;Stephen J. Keely;Robert J. Coffey;Kim E. Barrett

  • Enteroinvasive bacteria alter barrier and transport properties of human intestinal epithelium: Role of iNOS and COX-2

    Silvia Resta–Lenert;Kim E. Barrett

Frequent Co-Authors

Dean D. Metcalfe
Dean D. Metcalfe National Institute of Allergy and Infectious Diseases
Lars Eckmann
Lars Eckmann University of California, San Diego
Donald G. Guiney
Donald G. Guiney University of California, San Diego
Stephen I. Wasserman
Stephen I. Wasserman University of California, San Diego
Roger Y. Tsien
Roger Y. Tsien University of California, San Diego
Carsten Schultz
Carsten Schultz Oregon Health & Science University
Joshua Fierer
Joshua Fierer University of California, San Diego
Martin F. Kagnoff
Martin F. Kagnoff University of California, San Diego
Philip M. Sherman
Philip M. Sherman University of Toronto
Cormac T. Taylor
Cormac T. Taylor University College Dublin

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