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D-Index & Metrics

Immunology

D-Index
100
Citations
41852
World Ranking
719
National Ranking
411

Medicine

D-Index
100
Citations
41985
World Ranking
8211
National Ranking
4255

Overview

Lars Eckmann is affiliated with the University of California, San Diego in the United States. Their research spans several interconnected fields, primarily within medicine, immunology and microbiology, and biochemistry, genetics and molecular biology. The scientist has contributed extensively to the study of molecular biology, immunology, parasitology, infectious diseases, and epidemiology.

The research topics covered by Lars Eckmann include parasitic infections and diagnostics, gut microbiota and health, reproductive tract infections research, Helicobacter pylori-related gastroenterology studies, immune cell function and interaction, Toxoplasma gondii research studies, and inflammatory bowel disease.

Recent publications reflect their focus on immunological and gastrointestinal diseases. These include:

  • Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production, 2022, published in Science
  • IL-12 and IL-23 pathway inhibition in inflammatory bowel disease, 2023, Nature Reviews Gastroenterology & Hepatology
  • The fecal mycobiome in non-alcoholic fatty liver disease, 2021, Journal of Hepatology
  • Intestinal transgene delivery with native E. coli chassis allows persistent physiological changes, 2022, Cell
  • Sphingosine 1-phosphate modulation and immune cell trafficking in inflammatory bowel disease, 2022, Nature Reviews Gastroenterology & Hepatology

Lars Eckmann has collaborated frequently with several researchers, notably Yukiko Miyamoto, Marianne R. Spalinger, Elaine Hanson, Declan F. McCole, and Alina N. Santos.

The scientist's work appears across multiple publication venues, most commonly in bioRxiv (Cold Spring Harbor Laboratory), Nature Reviews Gastroenterology & Hepatology, Gastroenterology, Journal of Clinical Investigation, and PLoS Neglected Tropical Diseases.

Best Publications

  • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.

    Florian R. Greten;Lars Eckmann;Tim F. Greten;Jin Mo Park

  • IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

    Sergei Grivennikov;Eliad Karin;Janos Terzic;Janos Terzic;Daniel Mucida

  • A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

    Hyun Chae Jung;Lars Eckmann;Suk Kyun Yang;Asit Panja

  • Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.

    Sergei I. Grivennikov;Kepeng Wang;Daniel Mucida;C. Andrew Stewart

  • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface.

    Shipra Vaishnava;Cassie L. Behrendt;Anisa S. Ismail;Lars Eckmann

  • Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing

    Shin Maeda;Li-Chung Hsu;Li-Chung Hsu;Hongjun Liu;Hongjun Liu;Laurie A. Bankston;Laurie A. Bankston

  • Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry

    L Eckmann;M F Kagnoff;J Fierer

  • NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.

    Florian R. Greten;Florian R. Greten;Melek C. Arkan;Melek C. Arkan;Julia Bollrath;Li-Chung Hsu

  • Expression and Regulation of the Human β-Defensins hBD-1 and hBD-2 in Intestinal Epithelium

    Deborah A. O’Neil;Edith Martin Porter;Dirk Elewaut;G. Mark Anderson

  • EPITHELIAL CELLS AS SENSORS FOR MICROBIAL INFECTION

    M F Kagnoff;L Eckmann

  • Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

    Yi Duan;Yi Duan;Cristina Llorente;Cristina Llorente;Sonja Lang;Katharina Brandl

  • Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

    Jongdae Lee;Ji-Hun Mo;Kyoko Katakura;Irit Alkalay

  • Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis.

    S J Rasmussen;L Eckmann;A J Quayle;L Shen

  • Differential cytokine expression by human intestinal epithelial cell lines: Regulated expression of interleukin 8

    Lars Eckmann;Hyun Chae Jung;Cornelia Schürer-Maly;Asit Panja

  • Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

    Colby Zaph;Amy E. Troy;Betsy C. Taylor;Lisa D. Berman-Booty

  • Toll-like receptor 9–induced type I IFN protects mice from experimental colitis

    Kyoko Katakura;Jongdae Lee;Daniel Rachmilewitz;Gloria Li

  • The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4

    Li Chung Hsu;Jin Mo Park;Kezhong Zhang;Jun Li Luo

  • A NOD2-NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide

    Li Chung Hsu;Syed R. Ali;Shauna McGillivray;Ping Hui Tseng

  • NF-κB Is a Central Regulator of the Intestinal Epithelial Cell Innate Immune Response Induced by Infection with Enteroinvasive Bacteria

    Dirk Elewaut;Joseph A. DiDonato;Jung Mogg Kim;Jung Mogg Kim;Francis Truong

  • Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells.

    SK Yang;L Eckmann;A Panja;MF Kagnoff

Frequent Co-Authors

Martin F. Kagnoff
Martin F. Kagnoff University of California, San Diego
Michael Karin
Michael Karin University of California, San Diego
Joshua Fierer
Joshua Fierer University of California, San Diego
Frances D. Gillin
Frances D. Gillin University of California, San Diego
Kim E. Barrett
Kim E. Barrett University of California, San Diego
Sharon L. Reed
Sharon L. Reed University of California, San Diego
Peter B. Ernst
Peter B. Ernst University of California, San Diego
Bernd Schnabl
Bernd Schnabl University of California, San Diego
Nissi M. Varki
Nissi M. Varki University of California, San Diego
Florian R. Greten
Florian R. Greten Goethe University Frankfurt

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