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Molecular Biology
USA
2026

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Best Scientists

D-Index
279
Citations
348118
World Ranking
25
National Ranking
18

Molecular Biology

D-Index
278
Citations
324770
World Ranking
1
National Ranking
1

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2011 - Member of the National Academy of Medicine (NAM)
  • 2005 - Member of the National Academy of Sciences

Overview

Michael Karin is affiliated with the University of California, San Diego in the United States. Their research spans multiple fields with a focus on Medicine, with 148 publications, and Biochemistry, Genetics and Molecular Biology, contributing 108 publications.

The subfields within these areas include Molecular Biology (57 publications), Immunology (41), Oncology (33), Epidemiology (30), and Cancer Research (23). Their research topics cover a range of biomedical and clinical subjects, including:

  • Liver Disease Diagnosis and Treatment
  • Cancer Immunotherapy and Biomarkers
  • Endoplasmic Reticulum Stress and Disease
  • Immune cells in cancer
  • Inflammasome and immune disorders
  • Diet, Metabolism, and Disease
  • Cancer, Lipids, and Metabolism

Among the most cited recent papers associated with Michael Karin are:

  • Consensus guidelines for the definition, detection and interpretation of immunogenic cell death, 2020, Journal for ImmunoTherapy of Cancer
  • Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling, 2022, Immunity
  • Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation, 2021, Immunity
  • Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age?, 2021, Nature Reviews Clinical Oncology
  • ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis, 2023, Journal of Hepatology

Frequent collaborators include Shabnam Shalapour, Hua Su, Junlai Liu, Tatiana Kisseleva, and David A. Brenner, each contributing multiple coauthored publications.

Michael Karin has published extensively in notable venues such as bioRxiv (Cold Spring Harbor Laboratory) with 12 publications, Nature (9), Cell Metabolism (6), Nature Communications (5), and Proceedings of the National Academy of Sciences (5).

In addition to journal articles, they have contributed to book publications, including the recent title "ARDS in COVID-19 - Insights for Treatment" (2023), published by Frontiers Media.

Michael Karin has been recognized by election to prestigious bodies including the National Academy of Sciences in 2005 and the National Academy of Medicine in 2011.

Best Publications

  • Immunity, Inflammation, and Cancer

    Sergei I. Grivennikov;Florian R. Greten;Michael Karin

  • Mammalian MAP kinase signalling cascades

    Lufen Chang;Michael Karin

  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

    Lorenzo Galluzzi;Ilio Vitale;Stuart A. Aaronson;John M. Abrams

  • Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.

    Michael Karin;Yinon Ben-Neriah

  • Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases.

    Peter J. Barnes;Michael Karin

  • Nuclear factor-kappaB in cancer development and progression.

    Michael Karin

  • Missing Pieces in the NF-κB Puzzle

    Sankar Ghosh;Michael Karin

  • The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.

    Peter Angel;Michael Karin

  • A central role for JNK in obesity and insulin resistance

    Jiro Hirosumi;Gürol Tuncman;Lufen Chang;Cem Z. Görgün

  • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

    Benoit Dérijard;Benoit Dérijard;Masahiko Hibi;I-Huan Wu;I-Huan Wu;Tamera Barrett

  • NF-kappaB: linking inflammation and immunity to cancer development and progression.

    Michael Karin;Florian R. Greten

  • Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.

    Peter Angel;Masayoshi Imagawa;Robert Chiu;Bernd Stein

  • NF-κB at the crossroads of life and death

    Michael Karin;Anning Lin

  • AP-1 function and regulation.

    Michael Karin;Zheng-gang Liu;Ebrahim Zandi

  • The regulation of AP-1 activity by mitogen-activated protein kinases.

    Michael Karin

  • AP-1 as a regulator of cell life and death

    Eitan Shaulian;Michael Karin

  • The two NF-κB activation pathways and their role in innate and adaptive immunity

    Giuseppina Bonizzi;Michael Karin

  • NF-κB in cancer: from innocent bystander to major culprit

    Michael Karin;Yixue Cao;Florian R. Greten;Zhi-Wei Li

  • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer.

    Florian R. Greten;Lars Eckmann;Tim F. Greten;Jin Mo Park

  • Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

    Nathalie Auphan;Joseph A. DiDonato;Caridad Rosette;Arno Helmberg

Frequent Co-Authors

Sergei I. Grivennikov
Sergei I. Grivennikov Cedars-Sinai Medical Center
Florian R. Greten
Florian R. Greten Goethe University Frankfurt
Lars Eckmann
Lars Eckmann University of California, San Diego
David A. Brenner
David A. Brenner University of California, San Diego
Anning Lin
Anning Lin University of Chicago
Victor Nizet
Victor Nizet University of California, San Diego
Atsushi Matsuzawa
Atsushi Matsuzawa Tohoku University
Joseph A. DiDonato
Joseph A. DiDonato Cleveland Clinic
Maria T. Diaz-Meco
Maria T. Diaz-Meco Cornell University
Mark H. Ellisman
Mark H. Ellisman University of California, San Diego

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