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Joseph A. DiDonato

Joseph A. DiDonato

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
40312
World Ranking
6837
National Ranking
3153

Overview

Joseph A. DiDonato is affiliated with the Cleveland Clinic in the United States. Their research spans several fields including Biochemistry, Genetics and Molecular Biology, and Medicine, with a particular focus on molecular biology and physiology. Their work sits at the intersection of clinical biochemistry, public health, and rheumatology.

The scientist's main topics of investigation involve gut microbiota and health, diet and metabolism studies, metabolomics and mass spectrometry studies, as well as nutritional studies and diet. Additional areas of interest include metabolism and genetic disorders, folate and B vitamins research, and connections between tryptophan and brain disorders.

Joseph A. DiDonato has contributed to multiple publications in notable scientific venues. These include:

  • Nature Medicine
  • Journal of Biological Chemistry
  • Circulation
  • Arteriosclerosis Thrombosis and Vascular Biology
  • Cell Host & Microbe

Recent papers authored or coauthored by the scientist highlight their investigation into the link between gut microbial metabolites and cardiovascular disease, chronic kidney disease, and heart failure. Selected recent publications include:

  • "A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors" (2020, Cell)
  • "Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease" (2020, Arteriosclerosis Thrombosis and Vascular Biology)
  • "Long-Term Changes in Gut Microbial Metabolite Trimethylamine N-Oxide and Coronary Heart Disease Risk" (2020, Journal of the American College of Cardiology)
  • "Gut microbes impact stroke severity via the trimethylamine N-oxide pathway" (2021, Cell Host & Microbe)
  • "Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure" (2022, Circulation Heart Failure)

The scientist frequently collaborates with other researchers in their field, with notable co-authors including Stanley L. Hazen, Zeneng Wang, W.H. Wilson Tang, Xinmin S. Li, and Jennifer A. Buffa. Collaboration patterns show a consistent partnership with experts who contribute extensively to research on gut microbiota and cardiovascular health.

Best Publications

  • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

    Zeneng Wang;Elizabeth Klipfell;Brian J. Bennett;Robert A. Koeth

  • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

    Robert A Koeth;Zeneng Wang;Bruce S Levison;Jennifer A Buffa

  • Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

    Nathalie Auphan;Joseph A. DiDonato;Caridad Rosette;Arno Helmberg

  • A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

    Joseph A. DiDonato;Makio Hayakawa;David M. Rothwarf;Ebrahim Zandi

  • Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.

    Weifei Zhu;Jill C. Gregory;Elin Org;Jennifer A. Buffa

  • NF-κB and the link between inflammation and cancer.

    Joseph A. DiDonato;Frank Mercurio;Michael Karin

  • Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

    Zeneng Wang;Adam B. Roberts;Jennifer A. Buffa;Bruce S. Levison

  • Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation.

    Joseph DiDonato;Frank Mercurio;Caridad Rosette;Jian Wu-Li

  • An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models.

    Lyudmila G. Burdelya;Vadim I. Krivokrysenko;Thomas C. Tallant;Evguenia Strom

  • NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

    Yoram Devary;Caridad Rosette;Joseph A. DiDonato;Michael Karin

  • Protein carbamylation links inflammation, smoking, uremia and atherogenesis

    Zeneng Wang;Stephen J Nicholls;E Rene Rodriguez;Outi Kummu

  • A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors.

    Ina Nemet;Ina Nemet;Prasenjit Prasad Saha;Prasenjit Prasad Saha;Nilaksh Gupta;Nilaksh Gupta;Weifei Zhu;Weifei Zhu

  • γ-Butyrobetaine Is A Proatherogenic Intermediate in Gut Microbial Metabolism of L-Carnitine to TMAO

    Robert A. Koeth;Bruce S. Levison;Miranda K. Culley;Jennifer A. Buffa

  • Transmission of atherosclerosis susceptibility with gut microbial transplantation.

    Jill C. Gregory;Jennifer A. Buffa;Elin Org;Zeneng Wang

  • Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B.

    Joseph A DiDonato;F. Mercurio;M. Karin

  • Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential

    Adam B Roberts;Adam B Roberts;Xiaodong Gu;Xiaodong Gu;Jennifer A Buffa;Jennifer A Buffa;Alex G Hurd;Alex G Hurd;Alex G Hurd

  • NF-κB activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-κB-inducing kinase and IκB kinase

    Maryam Zamanian-Daryoush;Trine H. Mogensen;Joseph A. DiDonato;Bryan R. G. Williams

  • NF-κB Is a Central Regulator of the Intestinal Epithelial Cell Innate Immune Response Induced by Infection with Enteroinvasive Bacteria

    Dirk Elewaut;Joseph A. DiDonato;Jung Mogg Kim;Jung Mogg Kim;Francis Truong

  • Activation of NF-κB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes

    Nicole H. Purcell;Guilin Tang;Chenfei Yu;Chenfei Yu;Frank Mercurio

  • An abundant dysfunctional apolipoprotein A1 in human atheroma

    Ying Huang;Joseph A DiDonato;Bruce S Levison;Dave Schmitt

Frequent Co-Authors

Stanley L. Hazen
Stanley L. Hazen Cleveland Clinic Lerner College of Medicine
W.H. Wilson Tang
W.H. Wilson Tang Cleveland Clinic
Jonathan D. Smith
Jonathan D. Smith Cleveland Clinic
Michael Karin
Michael Karin University of California, San Diego
Edward A. Fisher
Edward A. Fisher New York University
Aldons J. Lusis
Aldons J. Lusis University of California, Los Angeles
Paul L. Fox
Paul L. Fox Cleveland Clinic Lerner College of Medicine
Lu Qi
Lu Qi Harvard University
Keith M. Channon
Keith M. Channon University of Oxford
J. Mark Brown
J. Mark Brown Cleveland Clinic

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