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D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
17069
World Ranking
14185
National Ranking
5981

Overview

J. Mark Brown is affiliated with the Cleveland Clinic in the United States and has made contributions primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research spans numerous subfields including Molecular Biology, Physiology, Epidemiology, Surgery, and Biochemistry.

The main topics addressed in their work include:

  • Gut microbiota and health
  • Diet and metabolism studies
  • Liver Disease Diagnosis and Treatment
  • Alcohol Consumption and Health Effects
  • Cancer, Hypoxia, and Metabolism
  • Inflammatory Bowel Disease
  • Lipid metabolism and biosynthesis

Selected recent papers by J. Mark Brown include:

  • Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression (2020), published in Metabolism
  • Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor niches (2021), published in Acta Neuropathologica Communications
  • Gut Microbiota-Derived Trimethylamine N-Oxide Contributes to Abdominal Aortic Aneurysm Through Inflammatory and Apoptotic Mechanisms (2023), published in Circulation
  • Novel mechanisms and clinical trial endpoints in intestinal fibrosis* (2021), published in Immunological Reviews
  • Disruption of the Gut Microbiota Confers Cisplatin Resistance in Epithelial Ovarian Cancer (2022), published in Cancer Research

Frequent co-authors collaborating with J. Mark Brown include:

  • Zeneng Wang
  • William J. Massey
  • Venkateshwari Varadharajan
  • Rakhee Banerjee
  • Anthony Horak

Their publications appear most often in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Gastroenterology
  • eLife
  • Neuro-Oncology
  • Journal of Lipid Research

Best Publications

  • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis

    Robert A Koeth;Zeneng Wang;Bruce S Levison;Jennifer A Buffa

  • Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.

    Weifei Zhu;Jill C. Gregory;Elin Org;Jennifer A. Buffa

  • Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential

    Adam B Roberts;Adam B Roberts;Xiaodong Gu;Xiaodong Gu;Jennifer A Buffa;Jennifer A Buffa;Alex G Hurd;Alex G Hurd;Alex G Hurd

  • Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages

    Xuewei Zhu;Ji Young Lee;Jenelle M. Timmins;J. Mark Brown

  • The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.

    Manya Warrier;Diana M. Shih;Amy C. Burrows;Daniel Ferguson

  • Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome.

    Michael B Fessler;Lawrence L Rudel;J Mark Brown

  • Isomer-specific regulation of metabolism and PPARγ signaling by CLA in human preadipocytes

    J. Mark Brown;Maria Sandberg Boysen;Søren Skov Jensen;Ron F. Morrison

  • The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

    Rebecca C. Schugar;Diana M. Shih;Manya Warrier;Robert N. Helsley

  • Cholesterol-regulated Translocation of NPC1L1 to the Cell Surface Facilitates Free Cholesterol Uptake

    Liqing Yu;Shantaram Bharadwaj;J. Mark Brown;Yinyan Ma

  • Cancer stem cell-specific scavenger receptor CD36 drives glioblastoma progression.

    James S. Hale;Balint Otvos;Maksim Sinyuk;Alvaro G. Alvarado

  • Conjugated Linoleic Acid in Humans: Regulation of Adiposity and Insulin Sensitivity

    J. Mark Brown;Michael K. McIntosh

  • Conjugated Linoleic Acid Induces Human Adipocyte Delipidation AUTOCRINE/PARACRINE REGULATION OF MEK/ERK SIGNALING BY ADIPOCYTOKINES

    J. Mark Brown;Maria Sandberg Boysen;Soonkyu Chung;Olowatoyin Fabiyi

  • Conjugated linoleic acid promotes human adipocyte insulin resistance through NFκB-dependent cytokine production

    Soonkyu Chung;J. Mark Brown;J. Nathan Provo;Robin Hopkins

  • Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism

    Caleb C. Lord;Gwynneth Thomas;J. Mark Brown

  • CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

    J. Mark Brown;Jenna L. Betters;Caleb Lord;Yinyan Ma

  • CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.

    Jennifer L. Cantley;Toru Yoshimura;Joao Paulo G. Camporez;Dongyan Zhang

  • α/β-Hydrolase Domain-6-Accessible Monoacylglycerol Controls Glucose-Stimulated Insulin Secretion

    Shangang Zhao;Yves Mugabo;Jose Iglesias;Li Xie

  • Biliary Sterol Secretion Is Not Required for Macrophage Reverse Cholesterol Transport

    Ryan E. Temel;Janet K. Sawyer;Liqing Yu;Caleb Lord

  • Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss.

    J. Mark Brown;Thomas A. Bell;Heather M. Alger;Janet K. Sawyer

  • The Serine Hydrolase ABHD6 Is a Critical Regulator of the Metabolic Syndrome

    Gwynneth Thomas;Jenna L. Betters;Caleb C. Lord;Amanda L. Brown;Amanda L. Brown

Frequent Co-Authors

Lawrence L. Rudel
Lawrence L. Rudel Wake Forest University
Stanley L. Hazen
Stanley L. Hazen Cleveland Clinic Lerner College of Medicine
Justin D. Lathia
Justin D. Lathia Cleveland Clinic Lerner College of Medicine
Rosanne M. Crooke
Rosanne M. Crooke Ionis Pharmaceuticals (United States)
Aldons J. Lusis
Aldons J. Lusis University of California, Los Angeles
Joseph A. DiDonato
Joseph A. DiDonato Cleveland Clinic
John S. Parks
John S. Parks Wake Forest University
Belinda Willard
Belinda Willard Cleveland Clinic
Mark C. Willingham
Mark C. Willingham Wake Forest University
H. Alex Brown
H. Alex Brown Vanderbilt University

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