World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
55
Citations
18239
World Ranking
3764
National Ranking
1473

Overview

Zhi-Yong Yang is affiliated with ModeX Therapeutics LLC in the United States. Their research expertise spans several fields, primarily within medicine, with a distinct focus on infectious diseases, oncology, radiology, nuclear medicine and imaging, and immunology. Their work contributes to a variety of topics connected to SARS-CoV-2 and COVID-19 research, CAR-T cell therapy, monoclonal and polyclonal antibodies, biosimilars, and bioanalytical methods.

The scientist has contributed to multiple recent publications, including:

  • A multispecific antibody against SARS-CoV-2 prevents immune escape in vitro and confers prophylactic protection in vivo, 2024, Science Translational Medicine
  • A phase 1/2a, multicenter, first-in-human, open-label clinical trial evaluating MDX2001, a tetraspecific T cell engager-expander in patients with advanced solid tumors, 2025, Journal of Clinical Oncology

Yang has collaborated frequently with several co-authors, including Ronnie R. Wei, John R. Mascola, Gary J. Nabel, John Misasi, and Lingshu Wang. These collaborations reflect interdisciplinary work that bridges fundamental and clinical applications.

The scientist's work has appeared predominantly in two publication venues:

  • Science Translational Medicine
  • Journal of Clinical Oncology

Within their study fields, Yang has concentrated on infectious diseases as the primary subfield, alongside oncology, radiology, nuclear medicine and imaging, and immunology. Their research topics further indicate a focus on:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 detection and testing
  • CAR-T cell therapy research
  • Monoclonal and Polyclonal Antibodies Research
  • Biosimilars and Bioanalytical Methods

Best Publications

  • Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

    Xueling Wu;Zhi Yong Yang;Yuxing Li;Carl Magnus Hogerkorp

  • Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01.

    Tongqing Zhou;Ivelin Georgiev;Xueling Wu;Zhi Yong Yang

  • Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans

    Gary J. Nabel;Elizabeth G. Nabel;Zhi Yong Yang;Bernard A. Fox

  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

    Jason S. McLellan;Marie Pancera;Chris Carrico;Jason Gorman

  • A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice

    Zhi Yong Yang;Wing Pui Kong;Yue Huang;Anjeanette Roberts

  • Development of a preventive vaccine for Ebola virus infection in primates

    Nancy J. Sullivan;Anthony Sanchez;Pierre E. Rollin;Zhi Yong Yang

  • pH-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus Is Mediated by the Spike Glycoprotein and Enhanced by Dendritic Cell Transfer through DC-SIGN

    Zhi Yong Yang;Yue Huang;Lakshmanan Ganesh;Kwanyee Leung

  • Induction of broadly neutralizing H1N1 influenza antibodies by vaccination

    Chih Jen Wei;Jeffrey C. Boyington;Patrick M. McTamney;Wing Pui Kong

  • Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo

    Elizabeth G. Nabel;Zhi Yong Yang;Gregory Plautz;Reza Forough

  • Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.

    Norman L. Letvin;John R. Mascola;Yue Sun;Darci A. Gorgone

  • Direct transfer of transforming growth factor beta 1 gene into arteries stimulates fibrocellular hyperplasia

    E G Nabel;L Shum;V J Pompili;Z Y Yang

  • Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination

    Nicole L. Yates;Nicole L. Yates;Hua Xin Liao;Hua Xin Liao;Youyi Fong;Allan DeCamp

  • Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

    Hua Xin Liao;Mattia Bonsignori;S. Munir Alam;Jason S. McLellan

  • Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

    Sung Youl Ko;Amarendra Pegu;Rebecca S. Rudicell;Zhi Yong Yang

  • Immunotherapy of malignancy by in vivo gene transfer into tumors

    Gregory E. Plautz;Zhi Yong Yang;Bei Yue Wu;Xiang Gao

  • Gene transfer in vivo with DNA-liposome complexes: safety and acute toxicity in mice.

    Mark J. Stewart;Gregory E. Plautz;Lisa Del Buono;Zhi Yong Yang

  • Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.

    Lei Chen;Young Do Kwon;Tongqing Zhou;Xueling Wu

  • Immunization by Avian H5 Influenza Hemagglutinin Mutants with Altered Receptor Binding Specificity

    Zhi Yong Yang;Chih Jen Wei;Wing Pui Kong;Lan Wu

  • Expression of Cyclin-Dependent Kinase Inhibitors in Vascular Disease

    Felix C. Tanner;Zhi Yong Yang;Eric Duckers;David Gordon

  • Distinct cellular interactions of secreted and transmembrane Ebola virus glycoproteins.

    Zhi Yong Yang;Rafael Delgado;Rafael Delgado;Ling Xu;Ling Xu;Robert F. Todd;Robert F. Todd

  • Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses

    Zhi Yong Yang;Heidi C. Werner;Wing Pui Kong;Kwanyee Leung

  • Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization.

    Elizabeth G. Nabel;David Gordon;Zhi Yong Yang;Ling Xu

  • Immune response in human melanoma after transfer of an allogeneic class I major histocompatibility complex gene with DNA–liposome complexes

    Gary J. Nabel;David Gordon;D. Keith Bishop;Brian J. Nickoloff

  • Cross-Neutralization of 1918 and 2009 Influenza Viruses: Role of Glycans in Viral Evolution and Vaccine Design

    Chih Jen Wei;Jeffrey C. Boyington;Kaifan Dai;Katherine V. Houser

  • Biochemical Analysis of the Secreted and Virion Glycoproteins of Ebola Virus

    Anthony Sanchez;Zhi Yong Yang;Ling Xu;Gary J. Nabel

Frequent Co-Authors

Gary J. Nabel
Gary J. Nabel ModeX Therapeutics
Elizabeth G. Nabel
Elizabeth G. Nabel Brigham and Women's Hospital
David J. Gordon
David J. Gordon University of Iowa
Anthony Sanchez
Anthony Sanchez University of Perpignan
John R. Mascola
John R. Mascola ModeX Therapeutics
Pascal Poignard
Pascal Poignard Grenoble Alpes University
Wayne C. Koff
Wayne C. Koff International AIDS Vaccine Initiative
Mark Connors
Mark Connors National Institute of Allergy and Infectious Diseases
Alfred E. Chang
Alfred E. Chang University of Michigan–Ann Arbor
Nancy J. Sullivan
Nancy J. Sullivan Boston University

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