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Immunology

D-Index
79
Citations
23465
World Ranking
1683
National Ranking
830

Overview

S. Munir Alam is affiliated with Duke University in the United States and focuses research efforts primarily in the fields of Immunology and Microbiology as well as Medicine. Their work spans a range of subfields, including Immunology, Virology, Infectious Diseases, Molecular Biology, and Radiology, Nuclear Medicine and Imaging.

The scientist's research has concentrated on several main topics, notably HIV Research and Treatment, Immune Cell Function and Interaction, Monoclonal and Polyclonal Antibodies Research, SARS-CoV-2 and COVID-19 Research, T-cell and B-cell Immunology, Immunotherapy and Immune Responses, and vaccines and immunoinformatics approaches.

Among recent papers authored or co-authored by S. Munir Alam are the following:

  • In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies, 2021, published in Cell
  • Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses, 2021, published in Nature
  • 3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates, 2020, published in Science Immunology
  • A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice, 2021, published in Science Translational Medicine
  • Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies, 2021, published in Cell

The work of S. Munir Alam has appeared frequently in several key publication venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell
  • Science Immunology
  • Science Translational Medicine
  • UNC Libraries

Collaborative research with multiple frequent co-authors forms part of Alam's body of work. These include Kevin O. Saunders, Robert J. Edwards, Barton F. Haynes, Kevin Wiehe, and David C. Montefiori.

Best Publications

  • Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

    Barton F. Haynes;Peter B. Gilbert;M. Juliana McElrath;Susan Zolla-Pazner

  • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

    Hua-Xin Liao;Rebecca Lynch;Tongqing Zhou;Feng Gao;Feng Gao

  • Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

    Jinghe Huang;Gilad Ofek;Leo Laub;Mark K. Louder

  • Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies

    Barton F. Haynes;Judith Fleming;E. William St. Clair;Herman Katinger

  • Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

    Mattia Bonsignori;Kwan Ki Hwang;Xi Chen;Chun Yen Tsao

  • Vaccine-induced Env V1-V2 IgG3 correlates with lower HIV-1 infection risk and declines soon after vaccination

    Nicole L. Yates;Nicole L. Yates;Hua Xin Liao;Hua Xin Liao;Youyi Fong;Allan DeCamp

  • Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

    Georgia D. Tomaras;Guido Ferrari;Xiaoying Shen;S. Munir Alam

  • Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

    Hua Xin Liao;Mattia Bonsignori;S. Munir Alam;Jason S. McLellan

  • Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

    Jinghe Huang;Byong H. Kang;Elise Ishida;Tongqing Zhou

  • The Role of Antibody Polyspecificity and Lipid Reactivity in Binding of Broadly Neutralizing Anti-HIV-1 Envelope Human Monoclonal Antibodies 2F5 and 4E10 to Glycoprotein 41 Membrane Proximal Envelope Epitopes

    S. Munir Alam;Mildred McAdams;David Boren;Michael Rak

  • CD4 T follicular helper cell dynamics during SIV infection

    Constantinos Petrovas;Takuya Yamamoto;Michael Y. Gerner;Kristin L. Boswell

  • Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

    Marie Pancera;Syed Shahzad-Ul-Hussan;Nicole A. Doria-Rose;Jason S. McLellan

  • An HIV-1 gp120 Envelope Human Monoclonal Antibody That Recognizes a C1 Conformational Epitope Mediates Potent Antibody-Dependent Cellular Cytotoxicity (ADCC) Activity and Defines a Common ADCC Epitope in Human HIV-1 Serum

    Guido Ferrari;Justin Pollara;Daniel Kozink;Tiara Harms

  • Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

    Mattia Bonsignori;Tongqing Zhou;Zizhang Sheng;Lei Chen

  • Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies

    Feng Gao;Mattia Bonsignori;Hua Xin Liao;Amit Kumar

  • A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses.

    Hua Xin Liao;Laura L. Sutherland;Shi Mao Xia;Mary E. Brock

  • Role of HIV membrane in neutralization by two broadly neutralizing antibodies

    S. Munir Alam;Marco Morelli;S. Moses Dennison;Hua-Xin Liao

  • The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model.

    Caridad Rosette;Guy Werlen;Mark A Daniels;Philmore O Holman

  • In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.

    Dapeng Li;Robert J. Edwards;Kartik Manne;David R. Martinez

  • Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

    S.Munir Alam;G.Mark Davies;Christina M. Lin;Tomasz Zal

  • Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group M consensus envelope glycoprotein

    Feng Gao;Eric A. Weaver;Zhongjing Lu;Yingying Li

Frequent Co-Authors

Barton F. Haynes
Barton F. Haynes Duke University
Hua-Xin Liao
Hua-Xin Liao Duke University
David C. Montefiori
David C. Montefiori Duke University
Georgia D. Tomaras
Georgia D. Tomaras Duke University
M. Anthony Moody
M. Anthony Moody Duke University
Robert Parks
Robert Parks Duke University
Mattia Bonsignori
Mattia Bonsignori Duke University
Richard M. Scearce
Richard M. Scearce Duke University
Thomas B. Kepler
Thomas B. Kepler Boston University
Garnett Kelsoe
Garnett Kelsoe Duke University

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