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Richard M. Scearce

Richard M. Scearce

D-Index & Metrics

Immunology

D-Index
50
Citations
9601
World Ranking
4237
National Ranking
1930

Overview

Richard M. Scearce is affiliated with Duke University in the United States. Their work primarily focuses on immunology and microbiology, with additional research contributions in biochemistry, genetics, and molecular biology. The scientist's expertise spans several subfields including immunology, virology, molecular biology, radiology, nuclear medicine and imaging, and infectious diseases.

The main research topics covered by Richard M. Scearce include:

  • HIV Research and Treatment
  • Immunotherapy and Immune Responses
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Monoclonal and Polyclonal Antibodies Research
  • Glycosylation and Glycoproteins Research
  • RNA Interference and Gene Delivery

Several notable recent papers authored or coauthored by Scearce include:

  • Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates, 2021, npj Vaccines
  • Immune checkpoint modulation enhances HIV-1 antibody induction, 2020, Nature Communications
  • Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection, 2022, Science Translational Medicine
  • Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity, 2022, Communications Biology

The scientist frequently publishes in venues such as:

  • UNC Libraries
  • npj Vaccines
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Science Translational Medicine

Richard M. Scearce regularly collaborates with several coauthors, including:

  • Robert Parks
  • Barton F. Haynes
  • Kevin O. Saunders
  • Maggie Barr
  • David C. Montefiori

Best Publications

  • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

    Hua-Xin Liao;Rebecca Lynch;Tongqing Zhou;Feng Gao;Feng Gao

  • Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies

    Barton F. Haynes;Judith Fleming;E. William St. Clair;Herman Katinger

  • Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

    Norbert Pardi;Michael J. Hogan;Rebecca S. Pelc;Hiromi Muramatsu

  • Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses.

    Norbert Pardi;Michael J. Hogan;Martin S. Naradikian;Kaela Parkhouse

  • The Role of Antibody Polyspecificity and Lipid Reactivity in Binding of Broadly Neutralizing Anti-HIV-1 Envelope Human Monoclonal Antibodies 2F5 and 4E10 to Glycoprotein 41 Membrane Proximal Envelope Epitopes

    S. Munir Alam;Mildred McAdams;David Boren;Michael Rak

  • A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses.

    Hua Xin Liao;Laura L. Sutherland;Shi Mao Xia;Mary E. Brock

  • Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group M consensus envelope glycoprotein

    Feng Gao;Eric A. Weaver;Zhongjing Lu;Yingying Li

  • Human Immunodeficiency Virus Type 1 gp41 Antibodies That Mask Membrane Proximal Region Epitopes: Antibody Binding Kinetics, Induction, and Potential for Regulation in Acute Infection

    S. Munir Alam;Richard M. Scearce;Robert J. Parks;Kelly Plonk

  • Polyvalent human immunodeficiency virus synthetic immunogen comprised of envelope gp120 T helper cell sites and B cell neutralization epitopes.

    T J Palker;T J Matthews;A Langlois;M E Tanner

  • Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment.

    B F Haynes;R M Scearce;D F Lobach;L L Hensley

  • Mapping of immunogenic regions of human T cell leukemia virus type I (HTLV-I) gp46 and gp21 envelope glycoproteins with env-encoded synthetic peptides and a monoclonal antibody to gp46.

    T J Palker;M E Tanner;R M Scearce;R D Streilein

  • Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.

    Kevin O. Saunders;Kevin Wiehe;Ming Tian;Priyamvada Acharya

  • Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge

    Todd Bradley;Justin Pollara;Sampa Santra;Nathan Vandergrift

  • Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides.

    Mary Kate Hart;Kent J. Weinhold;Richard M. Scearce;Eileen M. Washburn

  • HIV-1 Envelope gp41 Antibodies Can Originate from Terminal Ileum B Cells that Share Cross-Reactivity with Commensal Bacteria

    Ashley M. Trama;M. Anthony Moody;S. Munir Alam;Frederick H. Jaeger

  • Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies

    Ben-Jiang Ma;S Munir Alam;Eden P. Go;Xiaozhi Lu

  • Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation.

    B F Haynes;E A Harden;M J Telen;M E Hemler

  • Synthetic peptides containing T and B cell epitopes from human immunodeficiency virus envelope gp120 induce anti-HIV proliferative responses and high titers of neutralizing antibodies in rhesus monkeys.

    M K Hart;T J Palker;T J Matthews;A J Langlois

  • Cytotoxic antibodies to cloned rat islet cells in serum of patients with diabetes mellitus.

    G S Eisenbarth;M A Morris;R M Scearce

  • Removal of fibroblasts from human epithelial cell cultures with use of a complement fixing monoclonal antibody reactive with human fibroblasts and monocytes/macrophages.

    Kay H. Singer;Richard M. Scearce;Debbi T. Tuck;Leona P. Whichard

Frequent Co-Authors

Barton F. Haynes
Barton F. Haynes Duke University
Hua-Xin Liao
Hua-Xin Liao Duke University
S. Munir Alam
S. Munir Alam Duke University
David C. Montefiori
David C. Montefiori Duke University
Robert Parks
Robert Parks Duke University
M. Anthony Moody
M. Anthony Moody Duke University
Sampa Santra
Sampa Santra Beth Israel Deaconess Medical Center
Georgia D. Tomaras
Georgia D. Tomaras Duke University
Bette T. Korber
Bette T. Korber Los Alamos National Laboratory
Kevin O. Saunders
Kevin O. Saunders Duke University

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