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Thomas B. Kepler

Thomas B. Kepler

D-Index & Metrics

Microbiology

D-Index
78
Citations
21962
World Ranking
1282
National Ranking
568

Overview

Thomas B. Kepler is affiliated with Boston University in the United States. Their research spans multiple disciplines including Immunology and Microbiology as well as Medicine, with a particular focus on specialized subfields such as Immunology, Virology, Epidemiology, Radiology, Nuclear Medicine and Imaging, and Molecular Biology.

Kepler's work prominently addresses key topics within the life sciences. These include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • HIV Research and Treatment
  • Monoclonal and Polyclonal Antibodies Research
  • Influenza Virus Research Studies
  • Immunotherapy and Immune Responses
  • Glycosylation and Glycoproteins Research

The following list highlights a selection of Kepler's recent publications, showcasing their involvement in cutting-edge biomedical research:

  • Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth, 2020, Science
  • Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells, 2020, Frontiers in Immunology
  • An epitope-enriched immunogen expands responses to a conserved viral site, 2022, Cell Reports
  • Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2, 2022, Advanced Science
  • Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Kepler frequently collaborates with other researchers, with notable coauthors including:

  • Barton F. Haynes
  • M. Anthony Moody
  • John R. Mascola
  • Peter D. Kwong
  • Kevin Wiehe

The scientist has contributed extensively to various academic venues with repeated publications appearing in:

  • UNC Libraries
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • Science
  • Frontiers in Immunology

Best Publications

  • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

    Hua-Xin Liao;Rebecca Lynch;Tongqing Zhou;Feng Gao;Feng Gao

  • Stochasticity in Transcriptional Regulation: Origins, Consequences and Mathematical Representations

    Thomas B. Kepler;Timothy C. Elston

  • Focused evolution of hiv-1 neutralizing antibodies revealed by crystal structures and deep sequencing

    John R. Mascola;Gary Nabel;Barton F. Haynes;Xueling Wu

  • Invertebrate immune systems--not homogeneous, not simple, not well understood.

    Eric S Loker;Coen M. Adema;Si-Ming Zhang;Thomas B. Kepler

  • A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin

    James Whittle;Stephen C. Harrison;Barton F. Haynes;Hua-Xin Liao

  • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.

    Shuhua Han;K. Hathcock;Biao Zheng;T. B. Kepler

  • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study

    Barton F Haynes;Garnett Kelsoe;Stephen C Harrison;Thomas B Kepler;Thomas B Kepler

  • Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

    Mattia Bonsignori;Kwan Ki Hwang;Xi Chen;Chun Yen Tsao

  • Pathway level analysis of gene expression using singular value decomposition

    John K. Tomfohr;Jun Lu;Thomas B. Kepler

  • Advantage of rare HLA supertype in HIV disease progression.

    Elizabeth Trachtenberg;Bette Korber;Bette Korber;Cristina Sollars;Thomas B. Kepler;Thomas B. Kepler

  • Diversification of Ig Superfamily Genes in an Invertebrate

    Si-Ming Zhang;Coen M. Adema;Thomas B. Kepler;Eric S. Loker

  • Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

    Hua Xin Liao;Mattia Bonsignori;S. Munir Alam;Jason S. McLellan

  • A MODEL OF LARGE-SCALE PROTEOME EVOLUTION

    Ricard V. Solé;Ricard V. Solé;Ricard V. Solé;Romualdo Pastor-Satorras;Eric Smith;Thomas B. Kepler

  • The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling

    Hua Tang;Weiping Cao;Sudhir Pai Kasturi;Rajesh Ravindran

  • Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation

    Thomas B Kepler;Alan S Perelson

  • Microbial colonization influences early B-lineage development in the gut lamina propria

    Duane R. Wesemann;Andrew J. Portuguese;Andrew J. Portuguese;Andrew J. Portuguese;Robin M. Meyers;Robin M. Meyers;Robin M. Meyers;Michael P. Gallagher;Michael P. Gallagher;Michael P. Gallagher

  • Complex Antigens Drive Permissive Clonal Selection in Germinal Centers

    Masayuki Kuraoka;Aaron G. Schmidt;Takuya Nojima;Feng Feng

  • Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

    Mattia Bonsignori;Tongqing Zhou;Zizhang Sheng;Lei Chen

  • Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies

    Feng Gao;Mattia Bonsignori;Hua Xin Liao;Amit Kumar

  • Drug concentration heterogeneity facilitates the evolution of drug resistance

    Thomas B. Kepler;Alan S. Perelson

  • High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies.

    Hua-Xin Liao;Marc C. Levesque;Ashleigh Nagel;Ashlyn Dixon

Frequent Co-Authors

Barton F. Haynes
Barton F. Haynes Duke University
Hua-Xin Liao
Hua-Xin Liao Duke University
M. Anthony Moody
M. Anthony Moody Duke University
Garnett Kelsoe
Garnett Kelsoe Duke University
S. Munir Alam
S. Munir Alam Duke University
David C. Montefiori
David C. Montefiori Duke University
Georgia D. Tomaras
Georgia D. Tomaras Duke University
Mattia Bonsignori
Mattia Bonsignori Duke University
Stephen C. Harrison
Stephen C. Harrison Harvard University
Robert Parks
Robert Parks Duke University

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