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Mattia Bonsignori

Mattia Bonsignori

D-Index & Metrics

Immunology

D-Index
52
Citations
11614
World Ranking
4041
National Ranking
1845

Overview

Mattia Bonsignori is affiliated with Duke University in the United States. Their research intersects Immunology and Microbiology as well as Medicine, with a particular focus on several specialized subfields including Virology, Immunology, Radiology, Nuclear Medicine and Imaging, Infectious Diseases, and Molecular Biology.

The central topics of their work encompass:

  • HIV Research and Treatment
  • Monoclonal and Polyclonal Antibodies Research
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Glycosylation and Glycoproteins Research
  • Mosquito-borne diseases and control
  • SARS-CoV-2 and COVID-19 Research

Recent publications by Bonsignori include:

  • "Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response," 2020, published in Cell Host & Microbe
  • "Implementation of a Pooled Surveillance Testing Program for Asymptomatic SARS-CoV-2 Infections on a College Campus - Duke University, Durham, North Carolina, August 2-October 11, 2020," 2020, MMWR Morbidity and Mortality Weekly Report
  • "Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth," 2020, Science
  • "Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies," 2021, Cell
  • "Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth," 2020, Nature Immunology

Frequent co-authors collaborating with Bonsignori include Barton F. Haynes, Kevin O. Saunders, Kevin Wiehe, M. Anthony Moody, and David C. Montefiori. These collaborations have contributed to a substantial body of work in the aforementioned fields.

Bonsignori's research output is frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, Cell Host & Microbe, Cell, and Cell Reports. These journals and repositories collectively reflect the scientist's focus on immunology, infectious diseases, and molecular biology topics with an emphasis on viral immunology and antibody response mechanisms.

Best Publications

  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

    Jason S. McLellan;Marie Pancera;Chris Carrico;Jason Gorman

  • Focused evolution of hiv-1 neutralizing antibodies revealed by crystal structures and deep sequencing

    John R. Mascola;Gary Nabel;Barton F. Haynes;Xueling Wu

  • Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

    Mattia Bonsignori;Kwan Ki Hwang;Xi Chen;Chun Yen Tsao

  • Antibody-Dependent Cellular Cytotoxicity-Mediating Antibodies from an HIV-1 Vaccine Efficacy Trial Target Multiple Epitopes and Preferentially Use the VH1 Gene Family

    Mattia Bonsignori;Justin Pollara;M. Anthony Moody;Michael D. Alpert

  • Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG

    Georgia D. Tomaras;Guido Ferrari;Xiaoying Shen;S. Munir Alam

  • Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

    Hua Xin Liao;Mattia Bonsignori;S. Munir Alam;Jason S. McLellan

  • Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.

    Tongqing Zhou;Jiang Zhu;Xueling Wu;Stephanie Moquin

  • Magnitude and Breadth of the Neutralizing Antibody Response in the RV144 and Vax003 HIV-1 Vaccine Efficacy Trials

    David C. Montefiori;Chitraporn Karnasuta;Ying Huang;Hasan Ahmed

  • Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

    Mattia Bonsignori;Tongqing Zhou;Zizhang Sheng;Lei Chen

  • Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies

    Feng Gao;Mattia Bonsignori;Hua Xin Liao;Amit Kumar

  • Interaction with Cellular CD4 Exposes HIV-1 Envelope Epitopes Targeted by Antibody-Dependent Cell-Mediated Cytotoxicity

    Maxime Veillette;Anik Désormeaux;Halima Medjahed;Nour-Elhouda Gharsallah

  • A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

    Neville K. Kisalu;Azza H. Idris;Connor Weidle;Yevel Flores-Garcia

  • Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies

    Mattia Bonsignori;Mattia Bonsignori;Edward F. Kreider;Daniela Fera;R. Ryan Meyerhoff;R. Ryan Meyerhoff

  • Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape

    Katharine J. Bar;Chun-yen Tsao;Shilpa S. Iyer;Julie M. Decker

  • Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-infected Donor: Implications for Vaccine Design

    Mattia Bonsignori;David C. Montefiori;Xueling Wu;Xi Chen

  • Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

    Jason Gorman;Cinque Soto;Max M Yang;Thaddeus M Davenport

  • Polyreactivity and Autoreactivity among HIV-1 Antibodies

    Mengfei Liu;Guang Yang;Kevin Wiehe;Nathan I. Nicely

  • HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities.

    Justin Pollara;Mattia Bonsignori;M. Anthony Moody;Pinghuang Liu

  • HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design

    Christine A. Bricault;Karina Yusim;Michael S. Seaman;Hyejin Yoon

  • Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development.

    Mattia Bonsignori;Hua‐Xin Liao;Feng Gao;Wilton B. Williams

Frequent Co-Authors

Barton F. Haynes
Barton F. Haynes Duke University
Hua-Xin Liao
Hua-Xin Liao Duke University
M. Anthony Moody
M. Anthony Moody Duke University
David C. Montefiori
David C. Montefiori Duke University
S. Munir Alam
S. Munir Alam Duke University
Georgia D. Tomaras
Georgia D. Tomaras Duke University
Robert Parks
Robert Parks Duke University
Kevin O. Saunders
Kevin O. Saunders Duke University
Thomas B. Kepler
Thomas B. Kepler Boston University
Garnett Kelsoe
Garnett Kelsoe Duke University

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