His primary scientific interests are in Virology, Antibody, Neutralization, Epitope and Immunology. His Virology research is multidisciplinary, incorporating perspectives in HIV vaccine and Monoclonal antibody. His work on Humoral immunity as part of general Antibody study is frequently connected to Trimer, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His Neutralization study incorporates themes from Recombinant DNA, Complementarity determining region, Primary and secondary antibodies, Antigen and Molecular biology. His research integrates issues of Protein structure and Glycan in his study of Epitope. His Immunology research includes elements of AIDS Vaccines and Acquired immunodeficiency syndrome.
Wayne C. Koff mostly deals with Virology, Immunology, Antibody, Acquired immunodeficiency syndrome and Immune system. His work carried out in the field of Virology brings together such families of science as HIV vaccine, Monoclonal antibody and Antigen. His biological study spans a wide range of topics, including Immunogen and Microbiology.
His study in Antibody concentrates on Epitope and Neutralization. Wayne C. Koff interconnects Protein structure and Antigenicity in the investigation of issues within Neutralization. His studies deal with areas such as Cytotoxic T cell and Recombinant DNA as well as Virus.
Wayne C. Koff mainly investigates Virology, Antibody, Immune system, Epitope and Immunology. His Virology study combines topics in areas such as HIV vaccine, Immunogen and Antigen. His Antibody study focuses on Neutralization in particular.
The various areas that Wayne C. Koff examines in his Immune system study include Computational biology and Vaccination. His study looks at the relationship between Epitope and fields such as Monoclonal antibody, as well as how they intersect with chemical problems. His studies in Immunology integrate themes in fields like AIDS Vaccines, Acquired immunodeficiency syndrome and Gene.
Antibody, Virology, Epitope, Neutralization and Glycan are his primary areas of study. His work deals with themes such as AIDS Vaccines and Glycoprotein, which intersect with Antibody. In his research, Immune system, Recombinant DNA and Virus is intimately related to Antigen, which falls under the overarching field of Virology.
His research in Neutralization tackles topics such as Primary and secondary antibodies which are related to areas like Specific antibody, Lineage, Paratope, Molecular biology and Complementarity determining region. Wayne C. Koff has researched Glycan in several fields, including Glycosylation, Gp41 and Monoclonal antibody. His Immunology research includes themes of Acquired immunodeficiency syndrome and Intensive care medicine.
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Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target.
Laura M. Walker;Sanjay K. Phogat;Po-Ying Chan-Hui;Denise Wagner.
Broad neutralization coverage of HIV by multiple highly potent antibodies
Laura M. Walker;Michael Huber;Michael Huber;Katie J. Doores;Katie J. Doores;Emilia Falkowska;Emilia Falkowska.
HIV vaccine design and the neutralizing antibody problem
Dennis R Burton;Ronald C Desrosiers;Robert W Doms;Wayne C Koff.
Nature Immunology (2004)
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
Jason S. McLellan;Marie Pancera;Chris Carrico;Jason Gorman.
Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm
Melissa D. Simek;Wasima Rida;Frances H. Priddy;Pham Pung.
Journal of Virology (2009)
Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
Ann J. Hessell;Eva G. Rakasz;Pascal Poignard;Pascal Poignard;Lars Hangartner;Lars Hangartner.
PLOS Pathogens (2009)
Broadly Neutralizing Monoclonal Antibodies 2F5 and 4E10 Directed against the Human Immunodeficiency Virus Type 1 gp41 Membrane-Proximal External Region Protect against Mucosal Challenge by Simian-Human Immunodeficiency Virus SHIVBa-L
Ann J. Hessell;Eva G. Rakasz;David M. Tehrani;Michael Huber.
Journal of Virology (2010)
HIV-1 neutralizing antibodies induced by native-like envelope trimers
Rogier W. Sanders;Rogier W. Sanders;Marit J. Van Gils;Ronald Derking;Devin Sok;Devin Sok.
Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions
James B. Munro;Jason Gorman;Xiaochu Ma;Zhou Zhou.
Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
Emilia Falkowska;Khoa M. Le;Khoa M. Le;Alejandra Ramos;Alejandra Ramos;Katie J. Doores;Katie J. Doores;Katie J. Doores.
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