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Biology and Biochemistry

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51
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17144
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Overview

Pierre-Emmanuel Gleizes is affiliated with the Federal University of Toulouse Midi-Pyrénées in France. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions to molecular biology, oncology, structural biology, radiation, and rheumatology. Their scholarly output addresses a variety of topics related to RNA and protein synthesis mechanisms, cancer-related gene regulation, and epigenetics.

Their main research topics include:

  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • RNA research and splicing
  • Cancer-related gene regulation
  • Epigenetics and DNA methylation
  • Advanced electron microscopy techniques and applications
  • Advanced X-ray imaging techniques

Notable recent publications by Pierre-Emmanuel Gleizes feature work on ribosome biogenesis and its regulation, as well as blood and genetic diseases, including:

  • "p53 activation during ribosome biogenesis regulates normal erythroid differentiation", 2020, Blood
  • "Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function", 2021, Nucleic Acids Research
  • "NHP2 deficiency impairs rRNA biogenesis and causes pulmonary fibrosis and Høyeraal-Hreidarsson syndrome", 2020, Human Molecular Genetics
  • "The final step of 40S ribosomal subunit maturation is controlled by a dual key lock", 2021, eLife
  • "Diagnosis, treatment, and surveillance of Diamond-Blackfan anaemia syndrome: international consensus statement", 2024, The Lancet Haematology

The scientist frequently publishes in journals such as Blood, bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, The Lancet Haematology, and Human Molecular Genetics.

Collaborations are an important aspect of their work, with frequent coauthors including:

  • Marie-Françoise O'Donohue
  • Célia Plisson-Chastang
  • Simon Lebaron
  • Dana Rinaldi
  • Julien Marcoux

Best Publications

  • Latent transforming growth factor-β: Structural features and mechanisms of activation

    John S. Munger;John G. Harpel;Pierre-Emmanuel Gleizes;Roberta Mazzieri

  • An overview of pre‐ribosomal RNA processing in eukaryotes

    Anthony K. Henras;Célia Plisson-Chastang;Marie-Françoise O'Donohue;Anirban Chakraborty

  • Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β

    Irene Nunes;Pierre-Emmanuel Gleizes;Christine N. Metz;Daniel B Rifkin

  • Ribosomal Protein L5 and L11 Mutations Are Associated with Cleft Palate and Abnormal Thumbs in Diamond-Blackfan Anemia Patients

    Hanna T. Gazda;Hanna T. Gazda;Mee Rie Sheen;Adrianna Vlachos;Adrianna Vlachos;Valerie Choesmel;Valerie Choesmel

  • TGF‐β Latency: Biological Significance and Mechanisms of Activation

    Pierre‐Emmanuel Gleizes;John S. Munger;Irene Nunes;John G. Harpel

  • Roles of Eukaryotic Ribosomal Proteins in Maturation and Transport of Pre-18S rRNA and Ribosome Function

    Sébastien Ferreira-Cerca;Sébastien Ferreira-Cerca;Gisela Pöll;Pierre-Emmanuel Gleizes;Herbert Tschochner

  • Ribosomal Protein Genes RPS10 and RPS26 Are Commonly Mutated in Diamond-Blackfan Anemia

    Leana Doherty;Mee Rie Sheen;Adrianna Vlachos;Adrianna Vlachos;Valerie Choesmel;Valerie Choesmel

  • Impaired ribosome biogenesis in Diamond-Blackfan anemia

    Valérie Choesmel;Daniel Bacqueville;Jacques Rouquette;Jacqueline Noaillac-Depeyre

  • Sequential protein association with nascent 60S ribosomal particles.

    Cosmin Saveanu;Abdelkader Namane;Pierre-Emmanuel Gleizes;Alice Lebreton

  • Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps

    Cosmin Saveanu;David Bienvenu;Abdelkader Namane;Pierre‐Emmanuel Gleizes

  • The Genetic Landscape of Diamond-Blackfan Anemia.

    Jacob C. Ulirsch;Jacob C. Ulirsch;Jeffrey M. Verboon;Jeffrey M. Verboon;Shideh Kazerounian;Michael H. Guo

  • Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits.

    Marie-Françoise O’Donohue;Valérie Choesmel;Marlène Faubladier;Gwennaële Fichant

  • Identification and characterization of an eight-cysteine repeat of the latent transforming growth factor-β binding protein-1 that mediates bonding to the latent transforming growth factor-β1

    Pierre-Emmanuel Gleizes;Ronald C. Beavis;Roberta Mazzieri;Bin Shen

  • Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells

    Jacques Rouquette;Valérie Choesmel;Pierre-Emmanuel Gleizes

  • Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre‐ribosomal RNA processing defect in diamond–blackfan anemia

    Hanna T. Gazda;Milena Preti;Mee Rie Sheen;Marie-Francoise O'Donohue

  • Germline Mutation of RPS20, Encoding a Ribosomal Protein, Causes Predisposition to Hereditary Nonpolyposis Colorectal Carcinoma Without DNA Mismatch Repair Deficiency

    Taina T. Nieminen;Marie-Françoise O’Donohue;Marie-Françoise O’Donohue;Yunpeng Wu;Hannes Lohi

  • Specific Role for Yeast Homologs of the Diamond Blackfan Anemia-associated Rps19 Protein in Ribosome Synthesis

    Isabelle Léger-Silvestre;Jacqueline Marie Caffrey;Rosy Dawaliby;Diana Alehandrovna Alvarez-Arias

  • Late cytoplasmic maturation of the small ribosomal subunit requires RIO proteins in Saccharomyces cerevisiae.

    Emmanuel Vanrobays;Jean-Paul Gelugne;Pierre-Emmanuel Gleizes;Michele Caizergues-Ferrer

  • Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2

    Ivo Zemp;Thomas Wild;Thomas Wild;Marie-Françoise O'Donohue;Franziska Wandrey;Franziska Wandrey

  • Erratum: Ribosomal Protein Genes RPS10 and RPS26 Are Commonly Mutated in Diamond-Blackfan Anemia (DOI:10.1016/j.ajhg.2009.12.015)

    Leana Doherty;Mee Rie Sheen;Adrianna Vlachos;Valerie Choesmel

Frequent Co-Authors

Alan H. Beggs
Alan H. Beggs Harvard Medical School
Colin A. Sieff
Colin A. Sieff Harvard University
Peter E. Newburger
Peter E. Newburger University of Massachusetts Chan Medical School
Daniel B. Rifkin
Daniel B. Rifkin New York University
Charlotte M. Niemeyer
Charlotte M. Niemeyer University of Freiburg
Ulrike Kutay
Ulrike Kutay ETH Zurich
Vijay G. Sankaran
Vijay G. Sankaran Harvard University
Steven A. McCarroll
Steven A. McCarroll Harvard University
Daniel G. MacArthur
Daniel G. MacArthur Garvan Institute of Medical Research

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