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D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
19920
World Ranking
6261
National Ranking
2940

Overview

Joanne E. Murphy-Ullrich is affiliated with the University of Alabama at Birmingham in the United States. Their research spans primarily across the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with key focus areas including Molecular Biology, Cancer Research, Hematology, Rheumatology, and Nephrology.

The scientist's recent publications reflect significant engagement with mechanisms of cellular function and disease progression. Notable papers include:

  • Calreticulin is important for the development of renal fibrosis and dysfunction in diabetic nephropathy (2020, Matrix Biology Plus)
  • Identification of Inhibitors of Thrombospondin 1 Activation of TGF-β (2020, ACS Medicinal Chemistry Letters)
  • Thrombospondin-1 Signaling Through the Calreticulin/LDL Receptor Related Protein 1 Axis: Functions and Possible Roles in Glaucoma (2022, Frontiers in Cell and Developmental Biology)
  • Runx2 Deficiency in Osteoblasts Promotes Myeloma Resistance to Bortezomib by Increasing TSP-1-Dependent TGFβ1 Activation and Suppressing Immunity in Bone Marrow (2021, Molecular Cancer Therapeutics)
  • Autoinduction-Based Quantification of In Situ TGF-β Activity in Native and Engineered Cartilage (2024, Tissue Engineering Part C Methods)

Common venues in which their work is published include:

  • The FASEB Journal
  • Matrix Biology Plus
  • ACS Medicinal Chemistry Letters
  • Frontiers in Cell and Developmental Biology
  • Molecular Cancer Therapeutics

Frequent collaborators in their research include Mark J. Suto, Tianbai Wang, Michael B. Albro, Xiaoxuan Xu, and Timothy N. Trotter. These collaborations have contributed to advancing knowledge in areas related to cellular signaling and disease mechanisms.

The research topics Joanne E. Murphy-Ullrich engages with are:

  • Protease and Inhibitor Mechanisms
  • Multiple Myeloma Research and Treatments
  • TGF-β signaling in diseases
  • Osteoarthritis Treatment and Mechanisms
  • Cell Adhesion Molecules Research
  • Angiogenesis and VEGF in Cancer
  • Chronic Kidney Disease and Diabetes

This scientist's work has contributed to the broader understanding of signaling pathways such as TGF-β and their role in disease contexts, including glaucoma, myeloma resistance, diabetic nephropathy, and cartilage engineering. Their multidisciplinary approach spans molecular biology, cancer research, and nephrology, aligning with their publication record and collaborative networks.

Best Publications

  • Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

    Shyra J. Gardai;Kathleen A. McPhillips;S. Courtney Frasch;William J. Janssen

  • Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo

    Susan E Crawford;Susan E Crawford;Veronica Stellmach;Joanne E Murphy-Ullrich;Solange M.F Ribeiro

  • Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology

    Joanne E Murphy-Ullrich;Maria Poczatek

  • LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

    Anna P. Lillis;Lauren B. Van Duyn;Joanne E. Murphy-Ullrich;Dudley K. Strickland

  • Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism.

    Stacey Schultz-Cherry;Joanne E. Murphy-Ullrich

  • The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state?

    Joanne E. Murphy-Ullrich

  • Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

    Stacey Schultz-Cherry;Hui Chen;Deane F. Mosher;Tina M. Misenheimer

  • Calreticulin: non-endoplasmic reticulum functions in physiology and disease

    Leslie I. Gold;Paul Eggleton;Mariya T. Sweetwyne;Lauren B. Van Duyn

  • The Activation Sequence of Thrombospondin-1 Interacts with the Latency-associated Peptide to Regulate Activation of Latent Transforming Growth Factor-β

    Solange M.F. Ribeiro;Maria Poczatek;Stacey Schultz-Cherry;Matteo Villain

  • Revisiting the matricellular concept.

    Joanne E. Murphy-Ullrich;E. Helene Sage

  • Transforming growth factor-beta complexes with thrombospondin.

    Joanne E. Murphy-Ullrich;Stacey Schultz-Cherry;Magnus Höök

  • Thrombospondin binds and activates the small and large forms of latent transforming growth factor-beta in a chemically defined system.

    S Schultz-Cherry;S Ribeiro;L Gentry;J E Murphy-Ullrich

  • Thrombospondin modulates focal adhesions in endothelial cells.

    J E Murphy-Ullrich;M Höök

  • Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin

    Joanne E. Murphy-Ullrich;Virginia A. Lightner;Ikramudin Aukhil;Y. Z. Yan

  • The type 1 repeats of thrombospondin 1 activate latent transforming growth factor-beta.

    S Schultz-Cherry;J Lawler;J E Murphy-Ullrich

  • Cell signaling by reactive nitrogen and oxygen species in atherosclerosis

    Rakesh P Patel;Douglas Moellering;Joanne Murphy-Ullrich;Hanjoong Jo

  • EGF receptor regulation of cell motility: EGF induces disassembly of focal adhesions independently of the motility-associated PLCgamma signaling pathway

    Heng Xie;Manuel A. Pallero;Kiran Gupta;Philip Chang

  • Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.

    Joanne E. Murphy-Ullrich;Mark J. Suto

  • Mitogenesis, cell migration, and loss of focal adhesions induced by tenascin-C interacting with its cell surface receptor, annexin II.

    C Y Chung;J E Murphy-Ullrich;H P Erickson

  • Thrombospondin1 in tissue repair and fibrosis: TGF-β-dependent and independent mechanisms.

    Mariya T. Sweetwyne;Joanne E. Murphy-Ullrich

Frequent Co-Authors

Deane F. Mosher
Deane F. Mosher University of Wisconsin–Madison
Terry D. Oberley
Terry D. Oberley University of Wisconsin–Madison
James S. Hagood
James S. Hagood University of North Carolina at Chapel Hill
Namasivayam Ambalavanan
Namasivayam Ambalavanan University of Alabama at Birmingham
Stacey Schultz-Cherry
Stacey Schultz-Cherry St. Jude Children's Research Hospital
David D. Roberts
David D. Roberts National Institutes of Health
Thomas M. Lincoln
Thomas M. Lincoln Baystate Medical Center
Magnus Höök
Magnus Höök Texas A&M Health Science Center
Jack Lawler
Jack Lawler Beth Israel Deaconess Medical Center
Suzanne Oparil
Suzanne Oparil University of Alabama at Birmingham

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