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D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
8603
World Ranking
18033
National Ranking
7376

Overview

Kevin T. Bush is affiliated with the University of California, San Diego in the United States. Their research primarily focuses on the field of Medicine, with specific contributions to Pharmacology, Oncology, Molecular Biology, Nephrology, and Surgery.

The scientist's recent papers demonstrate an emphasis on pharmacogenetics, drug metabolism, and transport mechanisms. Notable publications include:

  • Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease, 2020, JCI Insight
  • Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning, 2020, Journal of Biological Chemistry
  • The Systems Biology of Drug Metabolizing Enzymes and Transporters: Relevance to Quantitative Systems Pharmacology, 2020, Clinical Pharmacology & Therapeutics
  • A key role for the transporter OAT1 in systemic lipid metabolism, 2021, Journal of Biological Chemistry
  • Significance of scores generated by a cancer therapy matching engine for patient outcomes, 2021, Journal of Clinical Oncology

Kevin T. Bush's research covers various interconnected topics including:

  • Pharmacogenetics and Drug Metabolism
  • Drug Transport and Resistance Mechanisms
  • Metabolomics and Mass Spectrometry Studies
  • Cannabis and Cannabinoid Research
  • Dialysis and Renal Disease Management
  • Pancreatic function and diabetes
  • Pharmacological Effects and Toxicity Studies

Frequent coauthors who have collaborated regularly with Bush include Sanjay K. Nigám, Liana C. Sayer, Layne Amerikaner, Robyn Moore, and Daniel L. Carlson. These collaborations highlight interdisciplinary approaches combining pharmacology, molecular biology, and clinical research.

The scientist's work is predominantly published in journals such as Journal of Marriage and the Family, Journal of Biological Chemistry, JCI Insight, Clinical Pharmacology & Therapeutics, and Journal of Clinical Oncology.

Best Publications

  • Eya protein phosphatase activity regulates Six1–Dach–Eya transcriptional effects in mammalian organogenesis

    Xue Li;Kenneth A. Oghi;Jie Zhang;Anna Krones

  • Proteasome Inhibition Leads to a Heat-shock Response, Induction of Endoplasmic Reticulum Chaperones, and Thermotolerance

    Kevin T. Bush;Alfred L. Goldberg;Sanjay K. Nigam

  • The Organic Anion Transporter (OAT) Family: A Systems Biology Perspective

    Sanjay K. Nigam;Kevin T. Bush;Gleb Martovetsky;Sun-Young Ahn

  • A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily.

    S K Nigam;A L Goldberg;S Ho;M F Rohde

  • Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters

    Sanjay K. Nigam;Wei Wu;Kevin T. Bush;Melanie P. Hoenig

  • Molecular Cloning and Characterization of NKT, a Gene Product Related to the Organic Cation Transporter Family That Is Almost Exclusively Expressed in the Kidney

    Carlos E. Lopez-Nieto;Guofeng You;Kevin T. Bush;Elvino J.G. Barros

  • Branching morphogenesis and kidney disease.

    Mita M. Shah;Rosemary V. Sampogna;Hiroyuki Sakurai;Kevin T. Bush

  • Changes in global gene expression patterns during development and maturation of the rat kidney

    Robert O. Stuart;Kevin T. Bush;Sanjay K. Nigam

  • Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes

    Wei Wu;Kevin T. Bush;Sanjay K. Nigam

  • Genesis and reversal of the ischemic phenotype in epithelial cells.

    Kevin T. Bush;Steven H. Keller;Sanjay K. Nigam

  • Multiple fibroblast growth factors support growth of the ureteric bud but have different effects on branching morphogenesis.

    Jizeng Qiao;Kevin T. Bush;Dylan L. Steer;Robert O. Stuart;Robert O. Stuart

  • The organic anion transporter family: from physiology to ontogeny and the clinic

    Douglas H. Sweet;Kevin T. Bush;Sanjay K. Nigam

  • Perturbations in maturation of secretory proteins and their association with endoplasmic reticulum chaperones in a cell culture model for epithelial ischemia.

    Galina Kuznetsov;Kevin T. Bush;Ping L. Zhang;Sanjay K. Nigam

  • Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney

    Tobias N. Meyer;Catherine Schwesinger;Kevin T. Bush;Robert O. Stuart;Robert O. Stuart

  • Dependence of Epithelial Intercellular Junction Biogenesis on Thapsigargin-sensitive Intracellular Calcium Stores

    Robert O. Stuart;Adam Sun;Kevin T. Bush;Sanjay K. Nigam

  • TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud.

    Kevin T Bush;Hiroyuki Sakurai;Dylan L Steer;Martin O Leonard

  • Selective degradation of E-cadherin and dissolution of E-cadherin-catenin complexes in epithelial ischemia.

    Kevin T. Bush;Tatsuo Tsukamoto;Sanjay K. Nigam

  • Identification of pleiotrophin as a mesenchymal factor involved in ureteric bud branching morphogenesis

    Hiroyuki Sakurai;Kevin T. Bush;Sanjay K. Nigam

  • Changes in gene expression patterns in the ureteric bud and metanephric mesenchyme in models of kidney development.

    Robert O. Stuart;Robert O. Stuart;Kevin T. Bush;Kevin T. Bush;Sanjay K. Nigam;Sanjay K. Nigam

  • Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.

    Sanjay K. Nigam;Kevin T. Bush

Frequent Co-Authors

Sanjay K. Nigam
Sanjay K. Nigam University of California, San Diego
Jeffrey D. Esko
Jeffrey D. Esko University of California, San Diego
Ruben Abagyan
Ruben Abagyan University of California, San Diego
David W. Rose
David W. Rose University of California, San Diego
Karl Willert
Karl Willert University of California, San Diego
Michael G. Rosenfeld
Michael G. Rosenfeld University of California, San Diego
Bernhard O. Palsson
Bernhard O. Palsson University of California, San Diego
Xue Li
Xue Li Chinese Academy of Agricultural Sciences
Terry Gaasterland
Terry Gaasterland University of California, San Diego
Richard L. Maas
Richard L. Maas Brigham and Women's Hospital

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