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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Molecular Biology

D-Index
79
Citations
20785
World Ranking
1043
National Ranking
25

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award

Overview

Melissa H. Little is affiliated with the Murdoch Children's Research Institute in Australia. Their research spans multiple disciplines, chiefly within biochemistry, genetics, and molecular biology, as well as medicine. They have accumulated a substantial number of publications, reflecting their involvement in various specialized subfields such as molecular biology, nephrology, pulmonary and respiratory medicine, genetics, and oncology.

The primary research topics addressed by Melissa H. Little include:

  • Renal and related cancers
  • Renal cell carcinoma treatment
  • Pluripotent stem cells research
  • Renal diseases and glomerulopathies
  • Genetic and kidney cyst diseases
  • Tissue engineering and regenerative medicine
  • Organ donation and transplantation

Their recent published papers include:

  • "Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation," 2020, Nature Materials
  • "Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk," 2020, Cell Stem Cell
  • "Organoids are not organs: Sources of variation and misinformation in organoid biology," 2023, Stem Cell Reports
  • "Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids," 2022, Nature Communications
  • "An In Vitro Differentiation Protocol for Human Embryonic Bipotential Gonad and Testis Cell Development," 2020, Stem Cell Reports

Melissa H. Little has collaborated frequently with several researchers, including:

  • Sara E. Howden
  • Jessica M. Vanslambrouck
  • Sean B. Wilson
  • Ker Sin Tan
  • Thomas Forbes

Their work has appeared repeatedly in a range of publication venues such as:

  • Journal of the American Society of Nephrology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Stem Cell Reports
  • Cell Stem Cell
  • Kidney International

Best Publications

  • Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

    Minoru Takasato;Minoru Takasato;Pei X. Er;Han Sheng Chiu;Barbara Maier

  • Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

    Minoru Takasato;P X Er;M Becroft;Jessica M Vanslambrouck

  • A side order of stem cells: the SP phenotype.

    Grant A. Challen;Melissa H. Little

  • A clinical overview of WT1 gene mutations

    Melissa Little;Christine Wells

  • Mice Lacking the Vascular Endothelial Growth Factor-B Gene (Vegfb) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia

    Daniela Bellomo;John P. Headrick;Ginters U. Silins;Carol A. Paterson

  • Mammalian Kidney Development: Principles, Progress, and Projections

    Melissa H. Little;Andrew P. McMahon

  • Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo.

    Cathelijne W. van den Berg;Laila Ritsma;M. Cristina Avramut;Loes E. Wiersma

  • Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation

    Kynan T. Lawlor;Jessica M. Vanslambrouck;J. William Higgins;Alison Chambon

  • Generation of kidney organoids from human pluripotent stem cells.

    Minoru Takasato;Pei X Er;Han S Chiu;Melissa H Little;Melissa H Little

  • Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript.

    W A Bickmore;K Oghene;M H Little;A Seawright

  • Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment.

    Kylie Georgas;Bree Rumballe;M Todd Valerius;Han Sheng Chiu

  • GUDMAP: The Genitourinary Developmental Molecular Anatomy Project

    Andrew P. McMahon;Bruce J. Aronow;Duncan R. Davidson;Jamie A. Davies

  • RNA binding by the Wilms tumor suppressor zinc finger proteins.

    Andrea Caricasole;Antonio Duarte;Stefan H. Larsson;Nicholas D. Hastie

  • Global Quantification of Tissue Dynamics in the Developing Mouse Kidney

    Kieran Matthew Short;Alexander Combes;James Lefevre;Adler Ju

  • The GUDMAP database – an online resource for genitourinary research

    Simon D. Harding;Chris Armit;Jane Armstrong;Jane Brennan

  • Characterisation and Trophic Functions of Murine Embryonic Macrophages Based Upon the Use of a Csf1r-EGFP Transgene Reporter

    Fiona Rae;Kyra Woods;Tedjo Sasmono;Naomi Vittoria Campanale

  • Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution

    Eric W. Brunskill;Bruce J. Aronow;Kylie Georgas;Bree Rumballe

  • A Null Mutation in the Inflammation-Associated S100 Protein S100A8 Causes Early Resorption of the Mouse Embryo

    Robert J. Passey;Elizabeth Williams;Agnieszka M. Lichanska;Christine Wells

  • Zinc Finger Point Mutations Within the Wt1 Gene in Wilms-Tumor Patients

    M H Little;J Prosser;A Condie;Paul Smith

  • Evaluation of variability in human kidney organoids.

    Belinda Phipson;Pei X. Er;Alexander N. Combes;Thomas A. Forbes;Thomas A. Forbes

Frequent Co-Authors

Sean M. Grimmond
Sean M. Grimmond University of Melbourne
Andrew P. McMahon
Andrew P. McMahon University of Southern California
David A. Hume
David A. Hume University of Queensland
Alicia Oshlack
Alicia Oshlack Peter MacCallum Cancer Centre
Bruce J. Aronow
Bruce J. Aronow Cincinnati Children's Hospital Medical Center
Jamie A. Davies
Jamie A. Davies University of Edinburgh
Peter Koopman
Peter Koopman University of Queensland
Rohan D. Teasdale
Rohan D. Teasdale University of Queensland
Nicholas D. Hastie
Nicholas D. Hastie University of Edinburgh
Duncan Davidson
Duncan Davidson University of Edinburgh

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