Her primary areas of study are Cell biology, Kidney, Kidney development, Internal medicine and Stem cell. Her Cell biology research includes elements of Cellular differentiation, Induced pluripotent stem cell and Nephron. Melissa H. Little interconnects Cell type, Transplantation and Directed differentiation in the investigation of issues within Kidney.
Her Kidney development research incorporates elements of Regulation of gene expression and Morphogenesis. Her Internal medicine research is multidisciplinary, relying on both Endocrinology and Pathology. The concepts of her Stem cell study are interwoven with issues in Molecular biology and Adult stem cell.
Her main research concerns Cell biology, Kidney, Kidney development, Induced pluripotent stem cell and Internal medicine. Melissa H. Little interconnects Cellular differentiation and Nephron in the investigation of issues within Cell biology. Bioinformatics is closely connected to Kidney disease in her research, which is encompassed under the umbrella topic of Kidney.
Her Kidney development study also includes
Melissa H. Little mostly deals with Cell biology, Induced pluripotent stem cell, Kidney, Nephron and Kidney development. Her studies in Cell biology integrate themes in fields like Cell type and Cellular differentiation. Melissa H. Little has researched Induced pluripotent stem cell in several fields, including Wnt signaling pathway, Reprogramming, Organoid, Kidney morphogenesis and Cell therapy.
Her biological study spans a wide range of topics, including Cell culture, Regenerative medicine, Kidney disease and Directed differentiation. Her Nephron research focuses on Organogenesis and how it connects with Mesenchyme, Downregulation and upregulation, microRNA, LIN28 and Process. Melissa H. Little focuses mostly in the field of Kidney development, narrowing it down to topics relating to Internal medicine and, in certain cases, Endocrinology, TSC1, Lesion and PI3K/AKT/mTOR pathway.
Melissa H. Little focuses on Cell biology, Induced pluripotent stem cell, Organoid, Cellular differentiation and Nephron. The various areas that Melissa H. Little examines in her Cell biology study include Cell type, Single-cell analysis, Kidney development and Gene expression profiling. Her Induced pluripotent stem cell research is multidisciplinary, incorporating elements of Reprogramming, Stem cell, Transgene and Cilium.
In her study, Directed differentiation is strongly linked to Kidney, which falls under the umbrella field of Organoid. Her Cellular differentiation research focuses on Wnt signaling pathway and how it relates to Lineage, Fate mapping and Kidney morphogenesis. As a member of one scientific family, she mostly works in the field of Nephron, focusing on Kidney metabolism and, on occasion, Organogenesis, microRNA, Downregulation and upregulation, Mesenchyme and LIN28.
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Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
Minoru Takasato;Minoru Takasato;Pei X. Er;Han Sheng Chiu;Barbara Maier.
A side order of stem cells: the SP phenotype.
Grant A. Challen;Melissa H. Little.
Stem Cells (2006)
Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney
Minoru Takasato;P X Er;M Becroft;Jessica M Vanslambrouck.
Nature Cell Biology (2014)
A clinical overview of WT1 gene mutations
Melissa Little;Christine Wells.
Human Mutation (1997)
Mice Lacking the Vascular Endothelial Growth Factor-B Gene (Vegfb) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia
Daniela Bellomo;John P. Headrick;Ginters U. Silins;Carol A. Paterson.
Circulation Research (2000)
Mammalian Kidney Development: Principles, Progress, and Projections
Melissa H. Little;Andrew P. McMahon.
Cold Spring Harbor Perspectives in Biology (2012)
Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript.
WA Bickmore;K Oghene;MH Little;A Seawright.
RNA binding by the Wilms tumor suppressor zinc finger proteins.
Andrea Caricasole;Antonio Duarte;Stefan H. Larsson;Nicholas D. Hastie.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution
Eric W. Brunskill;Bruce J. Aronow;Kylie Georgas;Bree Rumballe.
Developmental Cell (2008)
GUDMAP: The Genitourinary Developmental Molecular Anatomy Project
Andrew P. McMahon;Bruce J. Aronow;Duncan R. Davidson;Jamie A. Davies.
Journal of The American Society of Nephrology (2008)
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