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Hitoshi Endou

Hitoshi Endou

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
111
Citations
42809
World Ranking
941
National Ranking
45

Medicine

D-Index
111
Citations
42745
World Ranking
5355
National Ranking
114

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Hitoshi Endou is affiliated with Kyorin University in Japan and has contributed extensively to the field of biochemistry, genetics, and molecular biology. Their research output includes 63 publications primarily focused on molecular biology, biochemistry, immunology, and oncology, with specific subfields such as cancer research. The main themes of their work involve amino acid enzymes and metabolism, epigenetics and DNA methylation, polyamine metabolism and applications, immune cell function and interaction, mast cells and histamine, cancer, hypoxia, and metabolism, and drug transport and resistance mechanisms.

Endou's recent scientific papers cover a range of molecular and cellular topics related to cancer and amino acid transport. Key papers include:

  • First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors (2020, Investigational New Drugs)
  • Proteomics and phosphoproteomics reveal key regulators associated with cytostatic effect of amino acid transporter LAT1 inhibitor (2020, Cancer Science)
  • Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation (2020, Journal of Experimental & Clinical Cancer Research)
  • Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment (2022, Blood Advances)
  • Pharmacologic inhibition of LAT1 predominantly suppresses transport of large neutral amino acids and downregulates global translation in cancer cells (2022, Journal of Cellular and Molecular Medicine)

Frequent coauthors collaborating with Endou on multiple studies include Hiroki Okanishi, Ryuichi Ohgaki, Yoshikatsu Kanai, Suguru Okuda, and Keitaro Hayashi, reflecting an active network in molecular and cancer biology research.

Their work has been published repeatedly in venues such as the Proceedings for Annual Meeting of The Japanese Pharmacological Society, Scientific Reports, Journal of Pharmacological Sciences, Investigational New Drugs, and Cancer Science, indicating a focus on pharmacology, cancer biology, and molecular medicine.

The research topics associated with Endou emphasize amino acid transporters like LAT1 and their role in cancer cell metabolism, tumor environment adaptation, and vascular endothelium function. Studies also explore the interaction between molecular transport mechanisms and cellular signaling pathways, including mTORC1 activation and global translation regulation.

Best Publications

  • Molecular identification of a renal urate anion exchanger that regulates blood urate levels.

    Atsushi Enomoto;Hiroaki Kimura;Hiroaki Kimura;Arthit Chairoungdua;Yasuhiro Shigeta;Yasuhiro Shigeta

  • Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)

    Yoshikatsu Kanai;Hiroko Segawa;Hiroko Segawa;Ken-ichi Miyamoto;Hiroshi Uchino;Hiroshi Uchino

  • Expression Cloning and Characterization of a Novel Multispecific Organic Anion Transporter

    Takashi Sekine;Nobuaki Watanabe;Makoto Hosoyamada;Yoshikatsu Kanai

  • Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines.

    Osamu Yanagida;Yoshikatsu Kanai;Yoshikatsu Kanai;Arthit Chairoungdua;Do Kyung Kim

  • CATs and HATs: the SLC7 family of amino acid transporters

    François Verrey;Ellen I. Closs;Carsten A. Wagner;Manuel Palacin

  • The SLC22 drug transporter family.

    Hermann Koepsell;Hitoshi Endou

  • Cloning and Functional Characterization of a System ASC-like Na+-dependent Neutral Amino Acid Transporter

    Naoko Utsunomiya-Tate;Hitoshi Endou;Yoshikatsu Kanai

  • Identification and Characterization of Human Organic Anion Transporter 3 Expressing Predominantly in the Kidney

    Seok Ho Cha;Takashi Sekine;Jun-ichi Fukushima;Yoshikatsu Kanai

  • Molecular Cloning and Characterization of a New Multispecific Organic Anion Transporter from Rat Brain

    Hiroyuki Kusuhara;Takashi Sekine;Naoko Utsunomiya-Tate;Minoru Tsuda

  • Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity.

    Hiroko Segawa;Hiroko Segawa;Yoshiki Fukasawa;Ken-ichi Miyamoto;Eiji Takeda

  • Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta.

    Seok Ho Cha;Takashi Sekine;Hiroyuki Kusuhara;Hiroyuki Kusuhara;Erkang Yu

  • Transport of Amino Acid-Related Compounds Mediated by L-Type Amino Acid Transporter 1 (LAT1): Insights Into the Mechanisms of Substrate Recognition

    Hiroshi Uchino;Yoshikatsu Kanai;Do Kyung Kim;Michael F. Wempe

  • Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.

    Makoto Hosoyamada;Takashi Sekine;Yoshikatsu Kanai;Hitoshi Endou

  • Identification of multispecific organic anion transporter 2 expressed predominantly in the liver

    Takashi Sekine;Seok Ho Cha;Minoru Tsuda;Nopporn Apiwattanakul

  • Clinical and Molecular Analysis of Patients with Renal Hypouricemia in Japan-Influence of URAT1 Gene on Urinary Urate Excretion

    Kimiyoshi Ichida;Makoto Hosoyamada;Ichiro Hisatome;Atsushi Enomoto

  • Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans.

    Naohiko Anzai;Kimiyoshi Ichida;Promsuk Jutabha;Toru Kimura

  • Identification and characterization of the high-affinity choline transporter

    Takashi Okuda;Tatsuya Haga;Yoshikatsu Kanai;Hitoshi Endou

  • The multispecific organic anion transporter (OAT) family.

    Takashi Sekine;Seok Ho Cha;Hitoshi Endou

  • Molecular Physiology of Urate Transport

    Matthias A. Hediger;Richard J Johnson;Hiroki Miyazaki;Hitoshi Endou

  • Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids.

    Yoshiki Fukasawa;Hiroko Segawa;Hiroko Segawa;Ju Young Kim;Arthit Chairoungdua

Frequent Co-Authors

Yoshikatsu Kanai
Yoshikatsu Kanai Osaka University
Naohiko Anzai
Naohiko Anzai Chiba University
Atsushi Enomoto
Atsushi Enomoto Nagoya University
Hiroyuki Kusuhara
Hiroyuki Kusuhara University of Tokyo
Yuichi Sugiyama
Yuichi Sugiyama University of Tokyo
Toshiro Fujita
Toshiro Fujita University of Tokyo
Eiji Takeda
Eiji Takeda University of Tokushima
Masatomo Mori
Masatomo Mori Gunma University
Hisashi Yamanaka
Hisashi Yamanaka International University of Health and Welfare
Tsutomu Suzuki
Tsutomu Suzuki University of Tokyo

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