World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
95
Citations
32533
World Ranking
1904
National Ranking
1047

Medicine

D-Index
96
Citations
33051
World Ranking
9685
National Ranking
4986

Research.com Recognitions

  • 2006 - Member of the National Academy of Medicine (NAM)
  • 2000 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Kathleen M. Giacomini is affiliated with the University of California, San Francisco in the United States. Their research spans multiple areas within medicine and biochemistry, genetics, and molecular biology, focusing primarily on drug transport, pharmacogenetics, and pharmacological effects.

Their work covers a range of topics including:

  • Drug Transport and Resistance Mechanisms
  • Pharmacological Effects and Toxicity Studies
  • Pharmacogenetics and Drug Metabolism
  • Amino Acid Enzymes and Metabolism
  • Metabolism and Genetic Disorders
  • Diabetes Treatment and Management
  • HIV/AIDS Drug Development and Treatment

Kathleen M. Giacomini has contributed extensively to several publication venues. The most frequent venues include:

  • Clinical Pharmacology & Therapeutics
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Diabetes Care
  • The AAPS Journal

Recent notable publications include:

  • The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms, 2022, Clinical Pharmacology & Therapeutics
  • Membrane transporters in drug development and as determinants of precision medicine, 2024, Nature Reviews Drug Discovery
  • A New Era in Pharmacovigilance: Toward Real-World Data and Digital Monitoring, 2021, Clinical Pharmacology & Therapeutics
  • Opportunities and challenges for the computational interpretation of rare variation in clinically important genes, 2021, The American Journal of Human Genetics
  • The activities of drug inactive ingredients on biological targets, 2020, Science

The scientist collaborates frequently with a number of co-authors, including:

  • Sook Wah Yee
  • Megan L. Koleske
  • Ling Zou
  • Piet H. van der Graaf
  • Bianca Vora

Kathleen M. Giacomini's work intersects with several subfields such as oncology, molecular biology, pharmacology, pediatrics, perinatology, and genetics. Their interdisciplinary approach reflects the wide-ranging applications of pharmacogenetics and molecular biology in clinical and therapeutic contexts.

They have been recognized with notable awards including:

  • Member of the National Academy of Medicine (NAM), 2006
  • Fellow of the American Association for the Advancement of Science (AAAS), 2000

Best Publications

  • Membrane transporters in drug development.

    Kathleen M. Giacomini;Shiew Mei Huang;Donald J. Tweedie;Leslie Z. Benet

  • Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.

    Yan Shu;Steven A. Sheardown;Chaline Brown;Ryan P. Owen

  • SLC transporters as therapeutic targets: emerging opportunities

    Lawrence Lin;Sook Wah Yee;Richard B. Kim;Kathleen M. Giacomini

  • Metformin pathways: pharmacokinetics and pharmacodynamics

    Li Gong;Srijib Goswami;Kathleen M. Giacomini;Russ B. Altman

  • Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics.

    Y Shu;Y Shu;C Brown;RA Castro;RJ Shi

  • Organic cation transporters are determinants of oxaliplatin cytotoxicity.

    Shuzhong Zhang;Katherine S. Lovejoy;James E. Shima;Leah L. Lagpacan

  • Cloning and Functional Expression of a Human Liver Organic Cation Transporter

    Lei Zhang;Mark J. Dresser;Andrew T. Gray;Spencer C. Yost

  • Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.

    Deanna L. Kroetz;Christiane Pauli-Magnus;Laura M. Hodges;Conrad C. Huang

  • The concentrative nucleoside transporter family, SLC28.

    Jennifer H. Gray;Ryan P. Owen;Kathleen M. Giacomini

  • Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges

    Russell A. Wilke;Debbie W. Lin;Dan M. Roden;Paul B. Watkins

  • Emerging transporters of clinical importance: an update from the International Transporter Consortium.

    K M Hillgren;D Keppler;A A Zur;K M Giacomini

  • Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects

    Lisa R. Treviño;Noriko Shimasaki;Wenjian Yang;John C. Panetta

  • Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

    Yan Shu;Maya K. Leabman;Bo Feng;Lara M. Mangravite

  • Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters

    Mark J. Dresser;Maya Kaushal Leabman;Kathleen M. Giacomini

  • When good drugs go bad.

    Kathleen M. Giacomini;Ronald M. Krauss;Dan M. Roden;Michel Eichelbaum

  • Renal Transporters in Drug Development

    Kari M Morrissey;Sophie L Stocker;Matthias B Wittwer;Lu Xu

  • Pharmacogenomics: Challenges and Opportunities

    Dan M. Roden;Russ B. Altman;Neal L. Benowitz;David A. Flockhart

  • The pharmacogenetics research network: from SNP discovery to clinical drug response.

    K M Giacomini;C M Brett;R B Altman;N L Benowitz

  • Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin.

    Ying Chen;Shuanglian Li;Chaline Brown;Stephen Cheatham

  • cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects

    Katherine S. Lovejoy;Ryan C. Todd;Shuzhong Zhang;Michael S. McCormick

Frequent Co-Authors

Thomas E. Ferrin
Thomas E. Ferrin University of California, San Francisco
Deanna L. Kroetz
Deanna L. Kroetz University of California, San Francisco
Andrej Sali
Andrej Sali University of California, San Francisco
Esteban G. Burchard
Esteban G. Burchard University of California, San Francisco
Russ B. Altman
Russ B. Altman Stanford University
Ira Herskowitz
Ira Herskowitz University of California, San Francisco
Dan M. Roden
Dan M. Roden Vanderbilt University Medical Center
Mary V. Relling
Mary V. Relling St. Jude Children's Research Hospital
Mark J. Ratain
Mark J. Ratain University of Chicago

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