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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
13512
World Ranking
13079
National Ranking
5577

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Deanna L. Kroetz is affiliated with the University of California, San Francisco in the United States. Their research primarily spans Medicine and Biochemistry, Genetics, and Molecular Biology, with significant contributions focused on Oncology and Molecular Biology, alongside Pediatrics, Perinatology and Child Health, Genetics, and Cell Biology.

Their work covers topics including Cancer Treatment and Pharmacology, Drug Transport and Resistance Mechanisms, Pharmacological Effects and Toxicity Studies, Multiple Myeloma Research and Treatments, Microtubule and Mitosis Dynamics, Glioma Diagnosis and Treatment, and Glycosylation and Glycoproteins Research.

Recent papers authored or coauthored by Kroetz include:

  • Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy, 2020, Clinical Pharmacology & Therapeutics
  • Human Induced Pluripotent Stem Cell Derived Sensory Neurons are Sensitive to the Neurotoxic Effects of Paclitaxel, 2020, Clinical and Translational Science
  • New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium, 2022, Clinical Pharmacology & Therapeutics
  • P-Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer, 2020, Clinical Pharmacology & Therapeutics
  • Role for Drug Transporters in Chemotherapy-Induced Peripheral Neuropathy, 2020, Clinical and Translational Science

Frequently collaborating with other researchers, Kroetz has worked extensively with Mark J. Ratain, Kouros Owzar, Tore Bjerregaard Stage, Katherina C. Chua, and Flora Mulkey.

Deanna L. Kroetz has published mostly in venues such as UNC Libraries, Clinical and Translational Science, bioRxiv (Cold Spring Harbor Laboratory), Clinical Pharmacology & Therapeutics, and the British Journal of Cancer.

The research interests and publication record of Kroetz clearly align with advances in pharmacology and cancer treatment, with a particular focus on drug transporters, neurotoxicity of chemotherapy agents, and molecular mechanisms relating to cancer and molecular biology.

In recognition of their contributions to science, they were named a Fellow of the American Association for the Advancement of Science (AAAS) in 2017.

Best Publications

  • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.

    S S Lee;T Pineau;J Drago;E J Lee

  • Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability.

    Danxin Wang;Andrew D Johnson;Audrey C Papp;Deanna L Kroetz

  • HUMAN LIVER CARBAMAZEPINE METABOLISM. ROLE OF CYP3A4 AND CYP2C8 IN 10, 11-EPOXIDE FORMATION

    Bradley M. Kerr;Kenneth E. Thummel;Colleen J. Wurden;Susan M. Klein

  • Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids

    Zhigang Yu;Fengyun Xu;Linn M. Huse;Christophe Morisseau

  • Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene.

    Deanna L. Kroetz;Christiane Pauli-Magnus;Laura M. Hodges;Conrad C. Huang

  • Very important pharmacogene summary: ABCB1 (MDR1, P-glycoprotein).

    Laura M. Hodges;Svetlana M. Markova;Leslie W. Chinn;Jason M. Gow

  • The pharmacogenetics research network: from SNP discovery to clinical drug response.

    K M Giacomini;C M Brett;R B Altman;N L Benowitz

  • Comprehensive Pharmacogenetic Analysis of Irinotecan Neutropenia and Pharmacokinetics

    Federico Innocenti;Deanna L. Kroetz;Erin Schuetz;M. Eileen Dolan

  • Peroxisome Proliferator-activated Receptor α Controls the Hepatic CYP4A Induction Adaptive Response to Starvation and Diabetes *

    Deanna L. Kroetz;Philip Yook;Phillipe Costet;Pascale Bianchi

  • Natural variation in human membrane transporter genes reveals evolutionary and functional constraints

    Maya K. Leabman;Conrad C. Huang;Joseph DeYoung;Elaine J. Carlson

  • Cytochrome P450 pathways of arachidonic acid metabolism.

    Deanna L Kroetz;Darryl C Zeldin

  • Adherence-resistance relationships to combination HIV antiretroviral therapy

    David R. Bangsberg;Deanna L. Kroetz;Steven G. Deeks

  • A Genome-Wide Association Study Identifies Novel Loci for Paclitaxel-Induced Sensory Peripheral Neuropathy in CALGB 40101

    R. Michael Baldwin;Kouros Owzar;Hitoshi Zembutsu;Aparna Chhibber

  • Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein.

    Fa de Jong;TJ Scott-Horton;DL Kroetz;HL McLeod

  • Evolutionary Conservation of Vertebrate Blood―Brain Barrier Chemoprotective Mechanisms in Drosophila

    Fahima Mayer;Nasima Mayer;Leslie Chinn;Robert L. Pinsonneault

  • REGULATION AND INHIBITION OF ARACHIDONIC ACID ω-HYDROXYLASES AND 20-HETE FORMATION

    Deanna L Kroetz;Fengyun Xu

  • Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests.

    Tommy Andersson;David A. Flockhart;David B. Goldstein;Shiew Mei Huang

  • Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.

    Parikh S;Ouedraogo Jb;Goldstein Ja;Rosenthal Pj

  • Cytochrome P450 Eicosanoids are Activators of Peroxisome Proliferator-Activated Receptor α

    Valerie Y. Ng;Yong Huang;L. Manmohan Reddy;John R. Falck

  • Genome-wide association studies in pharmacogenomics: successes and lessons

    Alison A. Motsinger-Reif;Eric Jorgenson;Mary V. Relling;Deanna L. Kroetz;Deanna L. Kroetz

Frequent Co-Authors

Mark J. Ratain
Mark J. Ratain University of Chicago
Kathleen M. Giacomini
Kathleen M. Giacomini University of California, San Francisco
Howard L. McLeod
Howard L. McLeod Utah Tech University
Yusuke Nakamura
Yusuke Nakamura National Institutes of Biomedical Innovation, Health and Nutrition
Thomas E. Ferrin
Thomas E. Ferrin University of California, San Francisco
Federico Innocenti
Federico Innocenti University of North Carolina at Chapel Hill
Hope S. Rugo
Hope S. Rugo University of California, San Francisco
Lawrence N. Shulman
Lawrence N. Shulman University of Pennsylvania
Ira Herskowitz
Ira Herskowitz University of California, San Francisco

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